Research Terms
Organic Materials Medicinal Chemistry Physical Sciences Chemistry Bioinorganic Chemistry Organic Chemistry Polymer Chemistry Biopolymers
Industries
Patents:
1) Compositions and methods comprising stilbenoids and formulations thereof for adipocyte modulation. Patel, Niketa A.; Patel, Rekha S.; Bisht, Kirpal S. (2016), US9458086 B1, Issued on Oct 4th 2016.
2) Compositions, methods of use, and methods of treatment for Pain and CNS disorders. Amin, Jahanshah; Bisht, Kirpal S.; Gali, Meghanath. PCT Int. Appl. (2013), WO 2013003669.
3) Bisht, Kirpal S.; Khan, Pasha M.; Van Olphen, Alberto; Wu, Ruizhi. U.S. Patents (2012), US 8236853 B1. Issued on August 7, 2012.
4) Antiviral activity of Cylcopentene Nitro-ester and derivatives. Bisht, Kirpal S.; Van Olphen, Alberto; Khan, Pasha M.; Cynthia Bucher. U.S. Patents (2012), 8,318,804 B2. Issued on November 27, 2012.
5) Jak2 kinase inhibitor compounds . Sayeski, Peter P.; Keseru, Gyorgy M.; Bisht, Kirpal. PCT Int. Appl. (2010), WO 2010068710.
6) Synthesis of farnesylamine derivatives and their pharmaceutical use Kothapalli, Ravi; Bisht, Kirpal S. PCT Int. Appl. (2008), WO 2008143947.
7) Preparation of glycoside cyclic ester ring-opened oligomers as surfactants. Gross, Richard A.; Bisht, Kirpal; Kaplan, David; Swift, Graham; Deng, Fang U.S. (1999), US 5981743.
Research Papers and Reviews: 103
1. Design and the Synthesis of pseudo-Cyclodextrin Resorcin[4]arenes (CDR’s) and their Application in Thiocyanation Reactions in Water. Ali A. Husain and Kirpal S. Bisht. Journal of Chemistry. Communicated (2014).
2. The Jak2 Small Molecule Inhibitor, G6, Reduces the Tumorigenic Potential of T98G Glioblastoma Cells In Vitro and In Vivo. Rebekah Baskin; Sung O. Park; György M. Keser?; Kirpal S. Bisht; Heather L. Wamsley; Peter P. Sayeski. PLos One. (2014).
3. Influence of Resorcin[4]arenes Core Structure on the Spatial Directionality of Multi-arm Poly(ε-caprolactone)s. Ruizhi Wu, Talal F. Al-Azemi and Kirpal S. Bisht. RSC Advances. (2014). 4 (32), 16864-16870.
4. Protein Kinase C delta (PKCδ) splice variants modulate apoptosis pathway in 3T3L1 cells during adipogenesis: Identification of PKCδII inhibitor. Rekha Patel, André Apostolatos, Gay Carter, Joanne Ajmo, Meghanath Gali, Denise R. Cooper, Min You, Kirpal S. Bisht and Niketa A. Patel. Journal of Biological Chemistry, (2013) 288: 26834-26846.
5. The Small Molecule Inhibitor, G6, Significantly Reduces Bone Marrow Fibrosis and the Mutant Burden in a Mouse Model of Jak2-mediated Myelofibrosis. Annet Kirabo, Sung O. Park, Heather L. Wamsley, Meghanath Gali, Mary K. Reinhard, Zhizhuang Joe Zhao, Kirpal S. Bisht,György M. Keser?, Christopher R. Cogle, and Peter P. Sayeski. American Journal of Pathology (2012) 181(3), 858-65.
6. Identification of novel SAR properties of the Jak2 small molecule inhibitor G6:significance of the para-hydroxyl orientation. Rebekah Baskin, Meghanath Gali, Sung O. Park, Zhizhuang Joe Zhao,György M. Keser?, Kirpal S. Bisht, and Peter P. Sayeski. Bioorganic and Medicinal Chemistry Letters, (2012), 22, 1402-1407.
7. A46, a Benzothiophene Derived Compound, Suppresses Jak2-Mediated Pathologic Cell Growth. Anurima Majumder, Andrew Magis, Sung O. Park, Nicholas C. Figueroa, Rebekah Baskin, Annet Kirabo, Robert W. Allan, Zhizhuang Joe Zhao, Kirpal S. Bisht, György M. Keser?, and Peter P. Sayeski. Experimental Hematology, (2012) 40(1), 22-34.
8. The Jak2 Inhibitor, G6, Alleviates Jak2-V617F Mediated Myeloproliferative Neoplasia by Providing Significant Therapeutic Efficacy to the Bone Marrow. Annet Kirabo, Sung O. Park, Anurima Majumder, Meghanath Gali, Mary K. Reinhard, Heather L. Wamsley, Zhizhuang Joe Zhao|, Christopher R. Cogle, Kirpal S. Bisht, György M. Keser?, Peter P. Sayeski. Neoplasia, (2011), 13(11), 1058-1068.
9. The Stilbenoid Tyrosine Kinase Inhibitor, G6, Suppresses Jak2-V617F Mediated Human Pathological Cell Growth in vitro and in vivo. Annet Kirabo, Jennifer Embury, Róbert Kiss, Tímea Polgár, Meghanath Gali, Anurima Majumder, Kirpal S. Bisht, Christopher R. Cogle, György M. Keser?, and Peter P. Sayeski. Journal of Biological Chemistry, (2011); 286(6), 4280-4291.
10. Synthesis of Functional Polycarbonates from Renewable Resources. Kirpal S. Bisht and Talal F. Al-Azemi. ACS Symposium Series- Green Polymer Chemistry: Biocatalysis and Biomaterials (2010) 175-199.
11. Structure-Function Correlation of G6, a Novel Small Molecule Inhibitor of Jak2: Indispensability of the Stilbenoid Core. Anurima Majumder, Lakshmanan Govindasamy, Andrew Magis, Róbert Kiss, Tímea Polgár, Rebekah Baskin, Robert W. Allan, Mavis Agbandje-McKenna, Gary W. Reuther, György M. Keser?, Kirpal S. Bisht, and Peter P. Sayeski. Journal of Biological Chemistry, (2010), 285(41), 31399-31407.
12. Unusual regioselectivity in Pd(0)-catalyzed coupling of allylic monoacetates and nitroalkanes: one-pot isomerization–alkylation. Pasha M. Khan, Kirpal S. Bisht. Tetrahedron Letters. (2010), 51, 1407-1410.
13. Identification of a Novel Inhibitor of JAK2 Tyrosine Kinase by Structure-Based Virtual Screening. Róbert Kiss, Tímea Polgár, Jacqueline Sayyah, Nicholas C. Figueroa, Alan F. List, Lubomir Sokol, Kenneth S. Zuckerman, Meghanath Gali, Kirpal S. Bisht, Peter P. Sayeski, and György M. Keser?. Bioorganic and Medicinal Chemistry Letters, (2009), 19, 3598-3601.
14. One-shot Block Copolymerization of a Functional Seven-Membered Cyclic Carbonate Derived from L-Tartaric Acid with ε-Caprolactone. Ruzhi Wu, Talal F. Al Azemi and Kirpal S. Bisht. Macromolecules, (2009), 42 (7), 2401–2410.
15. Iron(III) Complexes of Metal-Binding Copolymers as Proficient Catalysts for Acid Hydrolysis of Phosphodiesters and Oxidative DNA Cleavage – Insight into the Rational Design of Functional Metallopolymers. Vasiliki Lykourinou, Ahmed I. Hanafy, Kirpal S. Bisht, Alexander Angerhofer, and Li-June Ming. European Journal of Inorganic Chemistry, (2009), 1199-1207.
16. Spatially Directional Multiarm Poly(e-Caprolactone) Based on Resorcin[4]arene Cavitand Core. Ruizhi Wu, Talal F. Al-Azemi and Kirpal S. Bisht. Chemical Communications, (2009), 1822-1824.Cited as a hot article www.rsc.org/chemcomm/hot published on Jan 13, 2009. The article is featured on the front cover of April 14, 2009 issue of the journal.
17. Functionalized Polycarbonate Derived from Tartaric Acid: Enzymatic Ring-Opening Polymerization of a Seven-Membered Cyclic Carbonate. Ruizhi Wu, Talal F. Al-Azemi, Kirpal S. Bisht. Biomacromolecules (2008), 9(10); 2921-2928.
18. How Well Should the Active Site and the Specific Recognition Be Defined for Proficient Catalyses? —Effective and Cooperative Polyphenol/Catechol Oxidation and Oxidative DNA Cleavage by a Copper(II)-Binding and H-bonding Copolymer. Vasiliki Lykourinou, Ahmed I. Hanafy, Giordano F. Z. da Silva, Kirpal S. Bisht, Randy W. Larsen, Brian T. Livingston, Alexander Angerhofer, and Li-June Ming. European Journal of Inorganic Chemistry, (2008), 2584–2592.
19. Synthesis of Resorcin[4]arene Cavitands by Ring Closing Metathesis. Sumedh N Parulekar, Kirankirti Muppalla, Frank R Fronczek and Kirpal S Bisht. Chemical Communications, (2007) 4901 - 4903.
20. Novel synthesis and polymerization of protected dihydroxy 7-member cyclic carbonate. Ruizhi Wu and Kirpal S Bisht. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2007), 48(1), 240-241.
21. Pd(0) catalyzed intramolecular alkylation: Stereoselective synthesis of furan and isoxazoline-2-oxide analogs. Pasha Khan, Ruizhi Wu, and Kirpal Bisht, Tetrahedron, 63, 1116-1126 (2007).
22. Synthesis of glycolipid analogs via highly regioselective macrolactonization catalyzed by lipase. Kirpal S. Bisht, Surbhi Bhatt, and Kirankirti Muppalla Tetrahedron Letters, 47, 8645-8649 (2006).
23. Enantioenriched substituted polycaprolactones by enzyme catalysis- in Polymer Biocatalysis and Biomaterials. Kirpal S. Bisht; Leelakrishna Kondaveti; Jon Stewart. ACS symposium series 900, (2005) pp366-392.
24. Effective heterogeneous hydrolysis of phosphodiester by pyridine-containing metallopolymers. Ahmed I. Hanafy, Vasiliki Lykourinou-Tibbs, Kirpal S. Bisht, and Li-June Ming. Inorganica Chimica Acta, 358(4), 1247-1252 (2005).
25. Synthesis of polyhydroxy cavitands and intramolecular inclusion of their octaester derivatives. Eric Efrain Dueno and Kirpal S. Bisht. Tetrahedron, 60 (48), 10859-10868 (2004).
26. A chemo-enzymatic synthesis of Imperanene via Enzymatic Asymmetrization of an Intermediary 1,3-diol. Jason Carr and Kirpal S. Bisht.
27. Intramolecular inclusion in novel octaester cavitands. Eric Dueno and Kirpal S. Bisht. Chemical Communications, 954 – 955 (2004).
28. Lipase-catalyzed resolution of racemic substituted b-Aryl- b-Lactams.
29. Lipase catalyzed Regioselective transesterification in peracylated sophorolipids catalyzed by Candida antarctica lipase-B.
30. A MALDI, TGA, TG/MS, and DEA study of the irradiation effects on PMMA. S. R. Tatro, G. R. Baker, Kirpal S. Bisht and J. P. Harmon. Polymer, 44, 167-176 (2003).
31. Solventless enantioelective ring-opening polymerization of substituted e-caprolactones by enzymatic catalysis. Talal F. Al Azemi, Leelakrishna Kondaveti, and Kirpal S. Bisht. Macromolecules. 35, 3380-86 (2002).
32. One-step synthesis of polycarbonates bearing pendant functional groups by ring-opening polymerization. Talal F. Al Azemi and Kirpal S. Bisht. Journal of Polymer Science-A: Polymer Chemistry. 40, 1267-1274 (2002).
33. Lipase-catalyzed solvent-free kinetic resolution of substituted racemic e-caprolactones. Leelakrishna Kondaveti, Talal F. Al Azemi, and Kirpal S. Bisht Tetrahedron Asymmetry. 13, 129-35 (2002).
34. Functional polycarbonates synthesis: Enzymatic approach. Talal F. Al-Azemi, and Kirpal S. Bisht. In Biocatalysis in Polymer Science, ACS, Washington, DC, Ch. 14, pp 156-171 (2002).
35. Synthesis of novel bis- and tris-(cyclic carbonate)s and their use in preparation of polymer networks. Talal F. Al Azemi and Kirpal S. Bisht. POLYMER. 43, 2161-67 (2002).
36. Novel poly(carbonate) and poly(carbonate-ester) networks. Talal F. Al Azemi and Kirpal S. Bisht. Polymer Prep. 43(1), 613-614 (2002).
37. Chiral polyesters by in-vitro enzymatic catalysis. Talal F. Al Azemi and Kirpal S. Bisht. Polymer Prep. 43(1), 704-705 (2002).
38. The synthesis and polymerization of glycolipid-based monomers. Kirpal S. Bisht and Richard A. Gross. In ACS Symposium Series # 786 Biopolymers from Polysaccharides and agroproteins. American Chemical Society, Washington, DC. Ch. 14, pp 222-239 (2001).
39. Synthesis of novel polycarbonates containing pendant carboxyl groups by enzyme catalysis. Talal F. Al-Azemi, Kirpal S. Bisht. Polymeric Materials: Science and Engineering, 84, 1045-46 (2001).
40. Enzyme-Catalyzed Ring-Opening Copolymerization of 5-Methyl-5-benzyloxycarbonyl-1,3-dioxan-2-one (MBC) with Trimethylene carbonate (TMC): Synthesis and Characterization. Talal F Al-Azemi, Julie P. Harmon and Kirpal S. Bisht. Biomacromolecules, 1, 493-500 (2000).
41. Glycolipids from Candida bombicola: Polymerization of a 6-O-acryloyl sophorolipid derivative. Kirpal S. Bisht, Wei Gao and Richard A. Gross. Macromolecules, 33, 6208-6210 (2000).
42. Functional polycarbonate synthesis: Enzymatic approach. Kirpal S. Bisht and Talal F. Al Azemi. Proc. Am. Chem. Soc.: Polymer Preprints, 41, 1865-66 (2000).
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