Competitive Advantages:
Modifies complex extracts from plants, Prepare pharmaceutical compositions, Applicable to other complex mixtures.
The present disclosure relates to methods of modifying complex extracts such that components or mixtures of components are selectively removed or added, thus providing a complex mixture that does not naturally occur with a refined or a tuned therapeutic or nutraceutical effect. In various aspects, the complex extract can be an extract obtained from one or more plants, e.g., an extract obtained from green tea leaves. The present disclosure pertains to compositions obtained by the disclosed methods, nutraceutical compositions comprising same, pharmaceutical compositions comprising same, and methods of treating various conditions, including physiological dysfunctions associated with elevated reactive oxygen species and/or inflammatory molecule, e.g., TNFa, expression using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Our researchers have developed a method of modifying complex extracts in which components or mixtures of components are selectively removed or added, thus providing a complex mixture that does not naturally occur. The method involves a selective deletion chromatography technique to prepare a composition which has a refined therapeutic effect. The complex extract can be an extract obtained from one or more plants, e.g., an extract obtained from green tea leaves. This method can be used to prepare nutraceutical compositions, pharmaceutical compositions, and compositions for treating various conditions, including physiological dysfunctions associated with elevated reactive oxygen species and/or inflammatory molecule.
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