Described herein are Dendrilla membranosa compounds and derivatives thereof. Also described herein are formulations that can contain an amount of one or more Dendrilla membranosa compounds or derivatives thereof and a carrier. Also described herein are methods of administering one or more Dendrilla membranosa compound and/or derivative thereof or a formulation thereof to a subject in need thereof.Biofilms are formed by all bacterial species. In the context of human disease, biofilms are the driving force behind many chronic infections, including UTIs, upper respiratory infections and periodontitis. Biofilms also form on implanted devices, such as catheters, artificial joints, pacemakers, and pins/plates. Interventions strategies targeting multi?drug resistant biofilms would save numerous lives and significantly limit morbidity. Therefore, there is an urgent unmet need to develop molecules that can actively impact cell viability with biofilms. USF inventors have discovered that the Antarctic sponge Dendrilla membranosa produces natural diterpene metabolites, that can eradicate bacterial biofilms. They discovered that these metabolites and their derivatives are effective in eradicating the biofilms of Methicillin-resistant Staphyloccocus aureus (MRSA) and Actinetobacter baumannii. This bypasses one of the main factors in bacterial drug resistance. The antibiofilm terpenoids were also tested against mammalian cells, and showed no signs of mammalian cytotoxicity. These metabolites can be used to decrease resistance in bacterial infections while also keeping the human host safe from harm.
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