Karam Soliman

 Issued Patents

¨  US Patent  7,357,950 B2 . Issued April 15, 2008 Topical treatment for dyshidrosis (pompholyx) and dry skin disorders 

¨  US Patent  7,666,451 B2   Issued February 23, 2010:  Method for Treatment of Pompholyx and Related Dry Skin Disorders.

Recent Publications

1.        Mazzio, E, A. Becker and KFA Soliman. Inflammation and inducible nitric oxide synthase have no effect on monoamine oxidase activity in glioma cells.  Biochem Pharmacol.  15:65:1719-1927 (2003).

2.   Mazzio EA and KFA Soliman. Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. Neurochem Res. 28(5):733-741 (2003).

3.     Sircar R and KFA Soliman. Effects of postnatal PCP treatment on locomotor behavior and striatal D (2) receptor. Pharmacol Biochem Behav.  74(4):943-452(2003).

4.    Mazzio and KFA Soliman. The role of glycolysis and gluconeogenesis in the cytoprotection of neuroblastoma cells against 1-methyl 4-phenylpyridinium ion toxicity.  Neurotoxicology.  24:137-147 (2003).

5.   Mazzio E and KFA Soliman Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro.  Neurosci Lett. 6; 337:77-80.

6.         Mazzio, E; K J. Yoon and K FA. Soliman.  Acetyl--carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells, Biochemical Pharmacology,  66: 297-306 (2003)

7.         Mazzio, E and K F A Soliman.  Glioma cell capacity in removing generated reactive oxygen species. Journal of Applied Toxicology.24: 99-106 (2004)

8.         Mazzio, E and K F A Soliman. Effect of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-pheylpyridinium toxicity in neuroblastoma cells. Biochemical Pharmacology 67: 1167-1184 ( 2004)

9.        Lee, E, H Chen, K R Shephard, N Lamango, K F A Soliman and CG Charlton. Inhibitory Effects of lysophosphatidylcholine on the dopaminergic system. Neurochemical Research 29: 1325-1334 (2004)

10.      Lee, E, H Chen, K R Shephard, N Lamango, K F A Soliman and CG Charlton. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neuroscience Research  48: 335-344 (2004)

11.     Mazzio E, R R. Reams and K F A Soliman. The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro. Brain Research  1004: 29-44 (2004)

12.     Yoon K, K Redda E Mazzio, and KFA Soliman. Inhibitory effects of novel tetrahydropyridine derivatives on nitric oxide and reactive oxygen species in glioma cells.  Drug Development Research  61:189-196 (2004)

13.     Mazzio, E, MG Kolta, RR Reams, and K F A Soliman.  Inhibitory effects of cigarette smoke on glial inducible   nitric oxide synthase and lack of protective properties against oxidative neurotoxins in vitro. Neurotoxicology 26: 49-62 (2005)

14.     Lee, E, K F A Soliman and C G Charlton. Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats. Neurotoxicology26: 27-38 (2005)

15.     Elsisi, N, S. Darling-Reed, EY Lee, E T Oriaku and K F Soliman. Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. Neuroscience Letters 375:91-96 (2005)

16.      Lee, E, H Chen, K F A Soliman and CG Charlton: Effects of Homocysteine on the Dopaminergic System and behavior in Rodents. Neurotoxicology26: 361-371 (2005).

17.     Lee, E, H. Chen, C. G. Charlton and KFA Soliman.  The Role of Phospholipid Methylation in 1-Methyl-4-Phenyl-Pyridinium ion (MPP⁺) induced Neurotoxicity in PC12 cells. Neurotoxicology,  26, 945-957(2005)

18.     K. R. Shepherd, E. Y. Lee , L. Schmued , S. F. Ali c,   E.T. Oriaku ,   N. S. Lamango, K. F.A. Soliman , and C. G. Charlton .The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on paraquat-induced neurochemical and behavioral changes in mice. Pharmacology Biochemistry Behavior 83:349-59 (2006)

19.     Lee, E; Z. Williams C. Goodman, E.T. Oriaku, M. Thomas, C. Harris and KFA Soliman.  Effects of NMDA Receptor Inhibition by Phencyclidine on the Neuronal Differentiation of PC12 Cells. Neurotoxicology.    27:558-66 (2006) 

20.     Williams, ZR; Goodman, CB and   Soliman, KFA . Anaerobic Glycolysis Protection Against 1-methy 4-phenylpyridinium (MPP⁺) Toxicity in C6 Glioma Cells.  In press.  J Neurochemical Research (2007)

21.     Mazzio, E and Soliman KF.  In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs. Phytotherapy Research 23: 385-398 (2009).

22.     Soliman, Y I; Mazzio, E Jackson T and Soliman KF "The effects of piroxicam in the attenuation of MPP+/MPTP toxicity in vitro and in vivo. Neurochemical Research 34:304-310 (2009).

23.     Becker A, Soliman KF. The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells. Neurochem Res. 34:1677-1684.  2009

24.     Reams^, R. R , D. Agrawal, M. B. Davis, S.Yoder, F. T. Odedina^,, N. Kumar, J. M Higginbotham, T.  Akinremi, S. Suther    and K. F.A. Soliman. Microarray Comparison of Prostate Tumor Gene Expression In African-American and Caucasian American Males: A Pilot Project Study. BioMed Central 10:4 Supp 1S:3 (2009)

25.     Mazzio E; Soliman KF. Evaluation of endogenous acidic metabolic products associated with anaerobic carbohydrate metabolism in tumor cells. Cell Biol Toxicology  26:177-188 (2010)

26.     Mazzio, E A. Soliman Y I, Soliman K F A.  Variable toxicological response to loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and hypoxia in diverse neural immortal cell lines . Cell Biology & Toxicology 26(6):527-39.Epub 2010 Apr 18.PMID: 20401737

27.      Mazzio, E and Soliman KF.  In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs. Part II. Phytotherapy Research. 2010 Jun 17. [Epub ahead of print]PMID: 20564497

28.     Badisa RB, Darling-Reed SF, Soliman KF.The Protective Role of D: -Glucose Against 1-Methyl-4-Phenylpyridinium Ion (MPP (+)): Induced Mitochondrial Dysfunction in C6 Astroglial Cells. Neurochem Res. May 28. [Epub ahead of print]PMID: 20508987 (2010)

29.     Mazzio, E A, F. Close and K. F.A.  Soliman.   The Biochemical and Cellular Basis for Nutraceutical Strategies to Attenuate Neurodegeneration in Parkinson’s Disease. Int. J. Mol. Sci.  12, 506-569 (2011)