Harry Nick

1.   “PIN*POINT Analysis on the Endogenous Manganese Superoxide Dismutase Promoter: Specific Demonstration of Sp1    Binding In Vivo” Kuo, S, Chokas, AL, Rogers, RJ, Nick, HS Am J Physiol Cell Physiol. 284(2):C528-34 (2003). PMID:12388080

2.      “Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.” Zhang, YC, Pileggi, A, Agarwal, A, Molano, RD, Powers, M, Brusko, T, Wasserfall, C, Goudy, K, Zahr, E, Poggioli, R, Scott-Jorgensen, M, Campbell-Thompson, M, Crawford, JM, Nick, HS, Flotte, T, Ellis, TM, Ricordi, C, Inverardi, L, Atkinson, MA Diabetes 52:708-716 (2003). PMID:12606512

3.      “Catalytic and Structural Effects of Amino-Acid Substitution at His 30 in Human Manganese Superoxide Dismuatase: Insertion of Val Cg into the Substrate Access Channel” Hearn AS, Stroupe, ME, Cabelli, D E, Ramillo, CA, Luba, JP, Tainer, JA, Nick, HS, Silverman, DN Biochemistry 42:2781-9 (2003). PMID:12627943

4.       “A cis-acting region regulates oxidized lipid-mediated induction of the human heme oxygenase-1 gene in endothelial cells” Hill-Kapturczak N, Voakes C, Garcia J, Visner GA, Nick HS, Agarwal A Arteriosclerosis, Thrombosis and Vascular Biology 23:1416-22 (2003). PMID:12805077

5.      “An internal enhancer regulates heme and cadmium-mediated induction of human heme oxygenase-1” Hill-Kapturczak, N, Sikorski, E, Voakes, C, Garcia, J, Nick, HS, Agarwal, A Am J Physiol Renal Physiol 285:F515-23 (2003). PMID:12783778

6.      “Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.”Zhang YC, Powers M, Wasserfall C, Brusko T, Song S, Flotte T, Snyder RO, Potter M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick HS, Agarwal A, Ellis TM, Atkinson MA. Gene Ther. 11:233-40 (2004). PMID:14737082

7.       “Amino-Acid Substitution at the Dimeric Interface of Human Manganese Superoxide Dismutase” Hearn AS, Fan, L, Lepock, JR, Luba, J, Greenleaf, WB, Cabelli, DE, Tainer, JA, Nick, HS, Silverman, DN The Journal of Biological Chemistry 279:5861-6 (2004). PMID:14638684

8.       “Potent anti-tumor effects of an active site mutant of human MnSOD: Evolutionary conservation of product inhibition” Davis, CA, Hearn, A S, Fletcher, B, Bickford, J, Garcia, JE, Leveque, V, Melendez, JA, Silverman, DN, Zucali, J, Agarwal, A, Nick, HS The Journal of Biological Chemistry 279:12769-12776 (2004). PMID:14688256

9.      “Role of Hydrogen Bonding in the Active Site of Human Manganese Superoxide Dismutase” Greenleaf WB, Perry JJ, Hearn AS, Cabelli DE, Lepock JR, Stroupe ME, Tainer JA, Nick HS, Silverman DN. Biochemistry 43:7038-7045 (2004). PMID:15170341

10.   “Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription.” Hock TD, Nick HS, Agarwal A The Biochemical Journal 383:209-18 (2004). PMID:15242350

11.  “Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells” Kim YM, Reed W, Lenz AG, Jaspers I, Silbajoris R, Nick HS, Samet JM Am J Physiol Lung Cell Mol Physiol 288:L432-41 (2005). PMID:15695543

12.  “Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat” Ellis RC, O'steen WA, Hayes RL, Nick HS, Wang KK, Anderson DK. Exp Neurol. 193:19-28 (2005). PMID:15817261

13.   “Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine” Pujols-Ayala I, Szczepanski J, Perry JJP, Cabelli DE, Ren X, Tainer JA, Vala MT, Nick HS, Silverman DN Biophysical Journal. 89:4171-9 (2005). PMID:16150974

14.   “Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice” Muller C, Braag SA, Herlihy JD, Wasserfall CH, Chesrown SE, Nick HS, Atkinson MA, Flotte TR. Lab Invest. 86:130-140 (2006). PMID:16424881

15.  “Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition” Chockalingam K, Luba J, Nick HS, Silverman DN, Zhao H.  FEBS J 273 (21): 4853-61 (2006). PMID:16999822

16.  “Structural mobility in human manganese superoxide dismutase” Quint P, Ayala I, Busby SA, Chalmers MJ, Griffin PR, Rocca J, Nick HS, Silverman DN.  Biochemistry 45(27): 8209-15 (2006). PMID:16819819

17.  “Distinct functions of CCAAT enhancer-binding protein isoforms in the regulation of manganese superoxide dismutase during interleukin-1beta stimulation” Qiu X, Aiken KJ, Chokas AL, Beachy DE, Nick HS The Journal of Biological Chemistry  283:25774-85 (2008). PMID:18559338

18.  “Quiescent adult neural stem cells are exceptionally sensitive to cosmic radiation” Encinas JM, Vazquez ME, Switzer RC, Chamberland DW, Nick H, Levine HG, Scarpa PJ, Enikolopov G, Steindler DA, Experimental  Neurology 210(1):274-9 (2008). PMID:18076878

19.  “Metabolic regulation of manganese superoxide dismutase expression via essential amino acid deprivation”        Aiken KJ, Bickford JS, Kilberg MS, Nick, HS.  The Journal of Biological Chemistry 283 (16): 10252-63 (2008). PMID:18187411

20.  “The kinetic mechanism of manganese-containing superoxide dismutase from Deinococcus radiodurans: a          specialized enzyme for the elimination of high superoxide concentrations” Abreu, IA, Hearn A, An H, Nick HS, Silverman DN, Cabelli DE. Biochemistry 47(8):2350-6 (2008). PMID:18247479

21.  “Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.”  Perry, J, Hearn, A, Cabelli, D, Nick, H, Tainer, J, Silverman D Biochemistry 48:3417-24. (2009). PMID:19265433

22.  “cPLA₂α Gene Activation by IL-1β is Dependent on an Upstream Kinase pathway, Enzymatic Activation and Downstream 15-lipoxygenase Activity: A Positive Feedback Loop” Walters, JN, Bickford, JS, Beachy, DE, Aiken, KJ, Herlihy, J-D, Strickland, MV, , Qiu, X, Nick, HS Cellular Signaling 23(12):1944-51 (2011). PMID:21771656

23.  “Induction of Group IVC Phospholipase A2 in Allergic Asthma: Transcriptional Regulation by TNF-α in Bronchoepithelial Cells.” Bickford JS, Newsom KJ, Herlihy JD, Muller C, Keeler B, Qiu X, Walters JN, Su N, Wallet SM, Flotte TR, Nick HS. Biochem J. 442(1):127-37 (2012). PMID:22082005

24.  “Regulation of Human Microsomal Prostaglandin E Synthase-1 by IL-1β requires a Distal Enhancer Element with a Unique Role for C/EBPβ” Walters JN, Bickford JS, Newsom KJ, Beachy DE, Barilovits SJ, Herlihy JD, Nick HS. Biochem J. 443(2):561-71 (2012). PMID: 22260630

25.  "Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency." Bickford JS, Mueller C, Newsom KJ, Barilovits SJ, Beachy DE, Herlihy JD, Keeler B, Flotte TR, Nick HS. J Cyst Fibros. S1569-1993(12)00153-1 (2012). PMID:22985691.

26.  "A Distal Enhancer Controls Cytokine-dependent Human cPLA2α Gene Expression." Bickford JS, Beachy DE, Newsom KJ, Barilovits SJ, Herlihy JD, Qiu X, Walters JN, Li N, Nick HS. J Lipid Res.  54(7):1915-26 (2013). PMID:23549331.

27.  " Human sensitivity to sound localization cues is disrupted by a mutation in the Kv3.3 voltage-gated potassium channel" Middlebrooks, JC Nick, HS, Subramony, SH, Advincula, J, Rosales, RL, Lee, LV, Ashizawa, T, Waters, MF. PLoS One  8(10):e76749 (2013). PMID:24116147

28.  " Conservation of the PTEN catalytic motif in bacterial undecaprenyl pyrophosphate phosphatase, BacA/UppP" Bickford JS and Nick, HS. Microbiology  159(Pt 12):2444-55 (2013). PMID:24068241

29.  "Characterization of a Mechanism to Inhibit Ovarian Follicle Activation" Barilovits, SJ, Newsom, KJ, Bickford, JS, Beachy, DE, Rhoton-Vlasak, A, and Nick, HS  submitted to Fertility and Sterility.