Award for Outstanding Contributions to Biomolecular Technologies

ABRF ▪ 2023
Fellow

National Academy of Inventors ▪ 2021
Pittsburgh Analytical Chemistry Award

Society of Analytical Chemists of Pittsburgh ▪ 2021
Florida Academy of Sciences Medal

Florida Academy of Sciences ▪ 2019
Distinguished Analytical Scientist Award

CPSA ▪ 2019
Fellow

Florida Inventors Hall of Fame ▪ 2019
Award for Distinguished Contribution in Clinical Mass Spectrometry

MSACL ▪ 2018
Award for Distinguished Contribution in Mass Spectrometry

American Society for Mass Spectrometry ▪ 1993

Publications

“Solvent Vapor Effects on Planar High-Field Asymmetric Waveform Ion Mobility Spectrometry”, L.C. Rorrer III, and R.A. Yost, Int. J. Mass Spectrom., 300, 173-181 (2011).

“Distribution Studies of Drugs and Metabolites in Tissues by Mass Spectrometric Imaging”, R.F. Reich, D.P Magparangalan, T.J. Garrett, and R.A. Yost, Chapter 14 in Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications, M.S. Lee and M. Zhu, ed., John Wiley & Sons, (2011), pp. 437-470.

“Ion Mobility Spectrometer-Field Asymmetric Ion Mobility Spectrometer-Mass Spectrometry”, M.J. Pollard, C.K. Hilton, K. Kaplan, R.A. Yost, and H.H. Hill Jr., Int. J. Ion Mobil. Spec., 14, 15-22 (2011).

“Lipid Analysis of Flat-mounted Eye Tissue by Imaging Mass Spectrometry with Identification of Contaminants in Preservation”, T.J. Garrett, R.F. Menger, W.W. Dawson, and R.A. Yost, Anal. Bioanal. Chem., 401, 103-113 (2011).

“Spherical FAIMS: Comparison of Curved Electrode Geometries”, M. Prieto and R.A. Yost, Int. J. Ion Mobil. Spectrom.,14, 61-69 (2011).

“Quantification of Lipids in Nerve Tissue Using MALDI Mass Spectrometric Imaging”, R.R. Landgraf, M.C. Prieto-Conway, T.J. Garrett, P.W. Stacpoole, and R.A. Yost, Rapid Commun. Mass Spectrom., 25, 3178-3184 (2011).

“Direct Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Imaging of Cellulose and Hemicelluloses in Populus Tissue”, K.A. Lunsford, G.F. Peter, and R.A. Yost, Anal. Chem.,83, 6722-6730 (2011).

“Characterization of Protonated Phospholipids as Fragile Ions in Ion Trap Mass Spectrometry”, T.J. Garrett, M.M Merves, and R.A. Yost, Int. J. Mass Spectrom., 308, 299-306 (2011).

“Quantitative Tandem Mass Spectrometric Imaging of Endogenous Acetyl-l-Carnitine from Piglet Brain Tissue Using an Internal Standard”, D.A. Pirman, P.R. Borum, and R.A. Yost, Anal. Chem., 83, 8575-8581 (2011).

“Mass Spectrometric Imaging for Drug Distribution in Tissues”, D.P Magparangalan, T.J. Garrett, D.M. Drexler, and R.A. Yost, Chapter 26 in ADME-Enabling Technologies for Drug Design and Development, D. Zhang and S. Surapaneni, ed., John Wiley & Sons, (2012), pp. 401-417.

“Comparison of Rectangular and Bisinusoidal Waveforms in a Miniature Planar High-Field Asymmetric Waveform Ion Mobility Spectrometer”, M. Prieto, C-W. Tsai, S. Boumsellek, R. Ferran, I. Kaminsky, S. Harris, and R.A. Yost, Anal. Chem., 83, 9237-9243 (2011).

“MALDI Mass Spectrometric Imaging of Cardiac Tissue Following Myocardial Infarction in a Rat Coronary Artery Ligation Model”, R.F. Menger, W.L. Stutts, D. Anbukumar, J.A. Bowden, D.A. Ford, and R.A. Yost, Anal. Chem., 84, 1117-1125 (2012).

“High-Field Asymmetric Waveform Ion Mobility Spectrometry with Solvent Vapor Addition: A Potentially Greener Analytical Technique for Bioanalysis”, C-W. Tsai, R.A. Yost, and T.J Garrett, Bioanalysis, 4, 1363-1375 (2012).

“Foreword”, R.A. Yost, Handbook of Mass Spectrometry, MS Lee, ed., John Wiley & Sons, p. xi, (2012).

“Quantitative MALDI Tandem Mass Spectrometric Imaging of Cocaine from Brain Tissue with a Deuterated Internal Standard”, D.A. Pirman, R.F. Reich, A. Kiss, R.M.A. Heeren, and R.A. Yost, Anal. Chem., 85, 1081–1089 (2013).

“Identifying Tissue-Specific Signal Variation in MALDI Mass Spectrometric Imaging using an Internal Standard”, D.A. Pirman, A. Kiss, R.M.A. Heeren, and R.A. Yost, Anal. Chem., 85, 1090–1096 (2013).

“Jim Morrison, Friend and Colleague”, C.G. Enke and R.A. Yost, J. Amer. Soc. Mass Spectrom. 24, 1319-1323 (2013).

“Characterization of Phosphatidylcholine Oxidation Products by MALDI MS”, W.L Stutts, R. F.Menger, A. Kiss, R.M.A. Heeren, R. A. Yost, Anal. Chem. 85, 11410-11419 (2013).

“Isotopic Ratio Outlier Analysis Global Metabolomics of Caenorhabditis elegans”, G. S. Stupp,C.S. Clendinen, R.Ajredini, M.A. Szewc, T. Garrett, R.F. Menger, R. A. Yost, C.Beecher, A. S. Edison, Anal.Chem., 85, 11858-11865 (2013).

“Standardized Method for Solubility and Storage of Capsaicin-based Solutions for Cough Induction”, M. Costanzo, P. Davenport, and RA. Yost, Cough, 10:6 doi: 10.1186/1745-9974-10-6 (2014).

“Performance Enhancement in the Measurement of 5 Endogenous Steroids in Human Serum by LC-MS/MS Combined with Differential Ion Mobility Spectrometry”, J.A. Ray, M.M. Kushnir, R.A. Yost, A.L. Rockwood, and A.W. Meikle, Clin. Chim. Acta, 438, 330-336 (2015).

“Solvent Vapor Effects in Planar High-Field Asymmetric Waveform Ion Mobility Spectrometry: Solvent Trends and Temperature Effects”, L.C. Rorrer, R.A. Yost, Intl. J. Mass Spectrom., 378,336-346 (2015).

“Metabolomic Analysis of Oxidative and Glycolytic Skeletal Muscles by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Imaging (MALDI MSI)”, Y. H. Tsai, T.J. Garrett, C.S. Carter, R.A. Yost, J. Amer. Soc. Mass Spectrom., 26, 915-923 (2015).

“MALDI Mass Spectrometric Imaging of the Nematode Caenorhabditis Elegans”, R. F. Menger, C. S. Clendinen, L.A. Searcy, A. S. Edison, R. A. Yost, Current Metabolomics, 3, 130-137 (2015).

“What’s the Most Meaningful Standard for Mass Spectrometry: Instrument Detection Limit or Signal-to-Noise Ratio?” T.L. Sheahan, R.A. Yost, Cur. Trends Mass Spectrom., October 2015, 2-7 (2015).

“Comparison of Blood Plasma Sample Preparation Methods for Combined LC-MS Lipidomics and Metabolomics”, R. E. Patterson, A. J Ducrocq, D.J. McDougall, T. J. Garrett, R. A. Yost, J. Chrom. B, 1002, 260-266 (2015). doi:10.1016/j.jchromb.2015.08.018

“Ionization Sources and Mass Analyzers in MS Imaging”, Y.H. Tsai, R.F. Menger, D. M. Drexler, R. A. Yost, T. J. Garrett, Bioanalysis, 7, 2629-2637, (2015). doi:10.4155/bio.15.187

“Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells”, C.Z. Ulmer, R.A. Yost, J. Chen, C.E. Mathews, T.J. Garrett, J. Proteomics Bioinform. 8(6) 126-132 (2015). PMID: 26401069

“The Role of Trapped Ion Mass Spectrometry for Imaging”, T. J. Garrett and R. A. Yost, Chapter 14 in Practical Aspects of Trapped Ion Mass Spectrometry, Volume V: Applications of Ion Trapping Devices, R.E. March and J.F.J. Todd, ed., CRC Press, (2016), pp. 417-436.

“Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives”, C. D. Chouinard, M. S. Wei, C. R. Beekman, R. H. J. Kemperman, R. A. Yost, Clin. Chem., 62, 124-133, (2016). doi: 10.1373/clinchem.2015.238840

“Lipotoxicity in Steatohepatitis Occurs Despite an Increase in Tricarboxylic Acid Cycle Activity”, R. E. Patterson, S. Kalavalapalli, C. M. Williams, M. Nautiyal, J. T. Mathew, J. Martinez, M. K. Reinhard, D. J. McDougall, J.R. Rocca, R. A. Yost, K. Cusi, T. J. Garrett, N. E. Sunny, Am. J. Physiol. Endocrinol. Metab. 310(7) E484-494 (2016). doi: 10.1152/ajpendo.00492.2015

“Isotopic Ratio Outlier Analysis of the S. cerevisiae Metabolome Using Accurate Mass Gas Chromatography/Time-of-Flight Mass Spectrometry: A New Method for Discovery”, Qiu Y., Moir R., Willis I., Beecher C., Tsai Y.H., Garrett T.J., Yost R.A., Kurland I.J., Anal. Chem. 88, 2747-2754 (2016). doi: 10.1021/acs.analchem.5b04263.

“Analysis of Ammonium Nitrate/Urea Nitrate with Crown Ethers and Sugars as Modifiers by Electrospray Ionization-Mass Spectrometry and Ion Mobility Spectrometry”, C.W. Tsai, A. Midley, C. Wu, and R.A. Yost, Anal Chem., 88, 9435-9442 (2016). DOI: 10.1021/acs.analchem.6b01322

“Maternal exposure to di-2 ethylhexylphthalate and adverse delivery outcomes: A systematic review”, L. Yaghjyan, G. L. Ghita, M. Dumont-Driscoll, S. Chang, R. A. Yost, Reprod. Tox., 65, 76-86 (2016). Doi: 10.1016/j.reprotox.2016.07.002

“Skeletal muscle fiber analysis by atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometric imaging at high mass and high spatial resolution”, Y. Tsai, D. R. Bhandari, T. J. Garrett, C.S. Carter, B. Spengler, R. A. Yost, Proteomics 16,1822-1824 (2016). DOI: 10.1002/pmic.201500536

“Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury”, A. Moghieb, H. M. Bramlett, J. H. Das, Z. Yang, T. Selig, R. A. Yost, M. Wang, W. D. Dietrich, K. W. Wang, Molec. Cell. Proteom. 15, 2379-2395, (2016). doi: 10.1074/mcp.M116.058115

“Precast Gelatin-Based Molds for Tissue Embedding Compatible with Mass Spectrometry Imaging”, E. L. Gill, R. A. Yost, V. Vedam-Mai, and T. Garrett. Anal. Chem. 89, 576-580 (2016). DOI: 10.1021/acs.analchem.6b04185

“Experimental and Theoretical Investigation of Sodiated Multimers of Steroid Epimers with Ion Mobility-Mass Spectrometry”, C.D. Chouinard, V.W.D. Cruzeiro, A.E. Roitberg, R.A. Yost, J. Am. Soc. Mass Spectrom. 28, 323-331 (2017). doi:10.1007/s13361-016-1525-7
“Identification of Meliatoxins in Melia azedarach Extracts Using Mass Spectrometry for Quality Control”, V. Cornelio, M. Forim, B. Perlatti, J. Fernandes, P. Vieira, M.P. Napolitano, R.A. Yost, M.F. da Silva, Planta Med., 83, 312-317 (2017). DOI: 10.1055/s-0042-115773

“Portable FAIMS: Applications and Future Perspectives”, M.T. Costanzo, J.J. Boock, R.H.J. Kemperman, M.S. Wei, C.R. Beekman, R.A. Yost, Int. J. Mass Spectrom. 422, 188-196 (2017), doi:10.1016/j.ijms.2016.12.007

“A Robust Lipidomics Workflow for Mammalian Cells, Plasma, and Tissue using Liquid-Chromatography High-Resolution Tandem Mass Spectrometry”, C.Z. Ulmer, R. Patterson, J. Koelmel, T.J. Garrett, R.A. Yost, Chapter 10 in Lipidomics. Methods in Molecular Biology, vol 1609, Humana Press, New York, NY, pp. 91-106, S.K. Bhattacharya, ed., Springer, (2017). DOI https://doi.org/10.1007/978-1-4939-6996-8_10

“Global UHPLC/HRMS Lipidomics Workflow for the Analysis of Lymphocyte Suspension Cultures”, CZ Ulmer, RA Yost, TJ Garrett, in: P. Wood (ed) Lipidomics. Neuromethods, vol 125, pp. 175-185, Humana Press, New York, NY (2017). DOI https://doi.org/10.1007/978-1-4939-6946-3_13

“Ion Mobility-Mass Spectrometry Separation of Steroid Structural Isomers and Epimers”, C. D. Chouinard, C.R. Beekman, R. H.J. Kemperman, H. M. King, R. A. Yost, Int. J. Ion Mobility Spectrom. 20, 31-39 (2017). doi:10.1007/s12127-016-0213-4

“Common Cases of Improper Lipid Annotation using High-Resolution Tandem Mass Spectrometry Data and Corresponding Limitations in Biological Interpretation”, J.P. Koelmel, C.Z. Ulmer, C.M. Jones, R.A. Yost, J.A. Bowden, Biochim. Biophys. Acta 1862, 766-770, (2017). doi.org/10.1016/j.bbalip.2017.02.016

“LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data”, J.P. Koelmel, N.M. Kroeger, C.Z. Ulmer, J.A. Bowden, R.E. Patterson, J.A. Cochran, C.W.W. Beecher, T.J. Garrett, R.A. Yost, BMC Bioinformatics, 18(1), 331 (2017). DOI: 10.1186/s12859-017-1744-3

“Investigating Differences in Gas-Phase Conformations of 25-Hydroxyvitamin D3 Sodiated Epimers using Ion Mobility-Mass Spectrometry and Theoretical Modeling”, C.D. Chouinard, V. W. D. Cruzeiro, A. E. Roitberg, R. A. Yost, J. Am. Soc. Mass Spectrom., 28, 1497-1505 (2017). doi.org/10.1007/s13361-017-1673-4

“Tandem Mass Spectrometry of Laser-Reduced Anthraquinones for Painted Works of Art”, M.P. Napolitano, M.C. Prieto, P.-C. Kuo, J. Arslanoglu, R.A. Yost, Int. J. Mass Spectrom., 421, 14-24 (2017). doi.org/10.1016/j.ijms.2017.05.012

“Application of Paper Spray Ionization for Explosives Analysis”, C. Tsai, C. A. Tipple, R. A. Yost, Rapid Commun. Mass Spectrom., 31, 1565-1572 (2017). Doi: https://doi.org/10.1002/rcm.7932

“Expanding lipdome coverage using LC-MS/MS data-dependent acquisition with automated exclusion list generation”, J. P. Koelmel, N.M. Kroeger, E. L. Gill, C. Z. Ulmer, J. A. Browden, R. E. Patterson, R. A. Yost, T. J. Garrett, J. Am. Soc. Mass Spectrom. 28, 908-917 (2017). doi: https://doi.org/10.1007/s13361-017-1608-0

“Improved experimental data processing for UHPLC–HRMS/MS lipidomics applied to nonalcoholic fatty liver disease”, R.E. Patterson, A.S. Kirpich, J.P. Koelmel, S. Kalavalapalli, A.M. Morse, K. Cusi, N.E. Sunny, L.M. McIntyre, T.J. Garrett, R.A. Yost, Metabolomics, 13, 142-155 (2017). Doi: https://doi.org/10.1007/s11306-017-1280-1

“LipidQC: Method Validation Tool for Visual Comparison to SRM 1950 Using NIST Interlaboratory Comparison Exercise Lipid Consensus Mean Estimate Values”, C.Z. Ulmer, J.M. Ragland, J.P. Koelmel, A. Heckert, C.M. Jones, T.J. Garrett, R.A. Yost, J.A. Bowden, Anal. Chem. 89, 13069-13073 (2017). DOI: 10.1021/acs.analchem.7b04042

“Monitoring Dopamine Ex Vivo during Electrical Stimulation Using Liquid-Microjunction Surface Sampling”, E.L. Gill, M. Marks, R.A. Yost, V. Vedam-Mai, T.J. Garrett, Anal. Chem. 89, 13658-13665 (2017). DOI: 10.1021/acs.analchem.7b04463

“Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s disease: Current Progress and Future Perspectives”, E.L. Gill, J.P. Koelmel, R.A. Yost, M.S. Okun, V. Vedam-Mai, and T.J. Garrett, Anal. Chem. 90, 2979-2986 (2018). DOI: 10.1021/acs.analchem.7b04084

“Examining heat treatment for stabilization of the lipidome”, J.P. Koelmel, C.M. Jones, C.Z. Ulmer, T.J. Garrett, R.A. Yost, T.B. Schock, J.A. Bowden, Bioanalysis, 10, 291-305 (2018). DOI: https://doi.org/10.4155/bio-2017-0209

“L-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells”, E.L. Gill, S. Raman, R.A. Yost, T.J. Garrett, V. Vedam-Mai, ACS Chem. Neurosci., 9 (5), 901-905 (2018). DOI: 10.1021/acschemneuro.7b00468

“Integration of paper spray ionization high?field asymmetric waveform ion mobility spectrometry for forensic applications”, C.W. Tsai, C.A. Tipple, R.A. Yost, Rap. Comm. Mass Spectrom., 32, 552-560 (2018). DOI: https://doi.org/10.1002/rcm.8068

“NIST lipidomics workflow questionnaire: an assessment of community-wide methodologies and perspectives”, J.A. Bowden, C.Z. Ulmer, C.M. Jones, J.P. Koelmel, R.A. Yost, Metabolomics, 14, 53-63 (2018). DOI: https://doi.org/10.1007/s11306-018-1340-1

“Cation-Dependent Conformations in 25-Hydroxyvitamin D3-Cation Adducts Measured by Ion Mobility-Mass Spectrometry and Theoretical Modeling”, C.D. Chouinard, V.W.D. Cruzeiro, R.H.J. Kemperman, N.R. Oranzi, A.E. Roitberg, and R.A. Yost, Int. J. Mass Spectrom., 430, 1-8 (2018). DOI: https://doi.org/10.1016/j.ijms.2018.05.013

"Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis", S. Kalavalapalli, F. Bril, J. Koelmel, K. Abdo, J. Guingab, P. Andrews, W-Y. Li, D. Jose, R.A. Yost, R. Frye, T. Garrett, K. Cusi, and N. Sunny, Am. J. Physiology-Endocrinology and Metabolism, (published online April 10, 2018). DOI: https://doi.org/10.1152/ajpendo.00023.2018

“Optimization of Folch, Bligh-Dyer, and Matyash Sample-to-Extraction Solvent Ratios for Mammalian Cell- and Plasma-Based Lipidomics Studies”, C.Z Ulmer; C.M Jones; R.A Yost; T.J Garrett, and J.A. Bowden, Anal. Chem. Acta, (published online August 8, 2018). DOI: https://doi.org/10.1016/j.aca.2018.08.004

“Environmental Lipidomics”, J.P. Koelmel, C.Z. Ulmer, C.M. Jones, T.J. Garrett, R.A. Yost, M.N.V. Prasad, and J.A. Bowden, Chapter in Encyclopedia of Lipidomics, in press (2018).

“Lipid Stability”, C.Z. Ulmer, J.P. Koelmel, C.M. Jones, T.J. Garrett, R.A. Yost, M.N.V. Prasad, and J.A. Bowden, Chapter in Encyclopedia of Lipidomics, in press (2018).

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Memberships

American Society for Mass Spectrometry, President; 2018 - 2020

Florida Board of Governors, State University System, Board of Directors; 2010 - 2012

Florida Advisory Council of Faculty Senates, Chairperson; 2010 - 2012

American Society for Mass Spectrometry, Treasurer; 2008 - 2010

Board of Trustees, University of Florida, Board of Directors; 2007 - 2008

American Society for Mass Spectrometry, Secretary; 1997 - 1999

Lawrence Livermore National Laboratory, Board of Advisors; 1995 - 2003

Peer Review Positions

Advanced Environmental Monitoring Review Panel, NASA; 2000 - 2003

Metallobiochemistry Study Section, NIH; 1990 - 1995

Biomedical Engineering and Technology Study Section, NIH; 1985 - 1990

Professional Presentations

Integrating Imaging Mass Spectrometry and Metabolomics; Pittcpn; Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy; 2013

FAIMS/MS: an Emerging Technique in the Clinical Laboratory; MSACL; Mass Spectrometry Applications to the Clinical Lab; 2013

Chip-Based FAIMS: New Concepts and the Role of Solvent Vapors; IMSC; 19th International Conference on Mass Spectrometry, Kyoto, Japan; 2012

MALDI/MSn Imaging of Lipid Oxidation Products in Nervous Tissue; International Conference on Imaging Mass Spectrometry, Oursense, Spain; 2012

Localization and Identification of Organic Materials in Samples from Artworks; Conference on Synchrotron Radiation in Art and Archaeology; 2012

Application of Paper Spray Ionization for Explosives Analysis; ASMS; 60th Annual Conference on Mass Spectrometry and Allied Topics; 2012

Other Professional Activities

1977-Research at LaTrobe University, Victoria, Australia; 1986 - Sabbatical, Army Chemical Research and Development Center; 1993-present - Affiliate Professor, UF School of Natural Resources and Environment; 1999-2001 - Fellow & Advisory Board Member, UF Institute for Science and Health Policy; 1999-present - Founding Member, William R. Maples Forensic Science Center; 2001 - Associate Dean for Research, College of Liberal Arts & Sciences, UF; 2001-present - Member, UF Center for Research at the Bio/Nano Interface; 2001-present - Senior Member, UF Shands Cancer Center; 2006-2009 - Chair Elect, Chair, and Past Chair, Faculty Senate, University of Florida; 2006-2010 - Vice Chair and Member, Advisory Council of Faculty Senates of Florida; 2007-2008 - Member, Board of Trustees, University of Florida; 2010-2012 - Chair, Advisory Council of Faculty Senates of Florida; 2010-2012 - Member, Florida Board of Governors, State University System; 2012-2014 - Past Chair, Advisory Council of Faculty Senates of Florida; 2012 - Visiting Pathologist, University of Utah, ARUP (Sabbatical)