Research Terms
Researchers at the University of Central Florida have identified new compounds that may treat malaria infections more effectively than current anti-malarial drugs. The malaria parasite, Plasmodium falciparum, has developed resistance to most anti-malarial treatments, including chloroquine and artemisinin. Since the UCF anti-malarial compounds have structures different from current antimalarials, the new compounds may have new cellular targets and have the ability to inhibit the growth of drug-resistant Plasmodium parasites, such as P. falciparum.
Technology 32882
UCF and Florida Atlantic University (FAU) researchers have isolated novel anti-malarial compounds from a library of enriched marine natural products, including cembranoid-type diterpenes, microsclerodermins, dercitamides and bis-indoles. Representative compound, Nortopsentin A, exhibits antiplasmodial activity against P. falciparum chloroquine-resistant Dd2 cells (IC50 0.6 micromole).
Technology 33963
UCF researchers have identified new anti-malarial compounds by 1) screening a library of optimized Aurora kinase inhibitors, and 2) repurposing human Aurora kinase proteins. Aurora kinase is a cell cycle regulatory protein involved in cell growth and development. The identified compounds inhibit the growth of chloroquine-resistant P. falciparum. These potent inhibitors (EC50 < 1 micromole) were identified in cell-based screening using SYBR Green I fluorescence-based assay.
Partnering Opportunity
The research teams are looking for partners to further develop the technologies for commercialization.
Stage of Development
Preclinical.
The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity, American Society for Microbiology, Antimicrobial Agents and Chemotherapy, p. 2362–2364 May 2013 Volume 57 Number 5, doi:10.1128/AAC.02091-12.
Researchers at the University of Central Florida and the Mayo Clinic are developing a diagnostic tool for predicting patient outcome in response to a particular cancer treatment. The tool consists of biomaterial scaffolds that mimic the in vivo 3D structure of the tumor microenvironment and can be used as an in vitro platform to screen cancer therapies.
The 3D screening platform consists of biomaterial scaffold compositions and methods for creating cell culture scaffolds of varying stiffness, porosity and mechanical properties. Such scaffolds enable patient-derived primary cancer cells to grow and retain their malignant phenotype in an in vitro environment. The biomaterials can consist of natural polymers, such as chitosan-alginate (CA), chitosan-chondroitin sulfate (C-CS), and chitosan-hyaluronic acid (C-HA) and be made using 3D printing and freeze-casting techniques.
3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines, Biomaterials, 2019 Oct;217:119311. doi: 10.1016/j.biomaterials.2019.119311. Epub 2019 Jun 28.