Researchers at the University of South Florida have discov-ered that by inhibiting PKC -iota or both PKC-iota and PKC zeta with ICA-1 or ACPD there is an increased melanoma cancer cell death. This is achieved without compromising normal melanocyte cells.
Melanoma is a type of cancer that occurs in melanocytes. Melano-cytes are responsible for the production of the pigment melanin and are derived from the neural crest. Melanoma is also called ma-lignant melanoma since it is the malignant tumor of melanocytes. The majority of melanoma occurs in skin but can rarely arise from the mucosal surfaces or areas which neural cells migrate.
Surgical resection is the primary means to control melanoma and it improves the survival rate if the melanoma has not metastasized. If it has metastasized, applications of immunotherapy, biologic thera-py, radiation therapy, or chemotherapy may improve survival.
Our results show that cell growth of malignant melanoma cells was reduced by applying PKC-? and PKC-? inhibitors. PKC-? and PKC-? heavily contribute to the migration of metastasized melanoma cells and migration can be suppressed using ICA -1 and ACPD. PKC-? and PKC-? overexpression in malignant melanoma can be reduced using inhibitors. Our results demonstrate that inhibiting PKC -iota and PKC-zeta with either ICA-1 or ACPD is an effective means to control melanoma proliferation.
Brochure
