Research Terms
Biotechnology Computer Science Life Sciences Medical Sciences Applied Science Technology
Keywords
Autoimmume Diseases Bioinformatics Cancer Biomarker Chemoinformatics Diabetes Druggable Genes Ebola Virus Genes To Drugs Genome-Wide Association Genomics Neurological Diseases Pancreatic Cancer Secretome Zika Virus
Industries
Makler A, Narayanan R. Mining Exosomal Genes for Pancreatic Cancer Targets.Cancer Genomics Proteomics. 2017 May-Jun;14(3):161-172.
Narayanan R (2016) Repurposing Drugs in the Genomics Era: Bioinformatics Approaches. MOJ Proteomics Bioinform 3(4): 00092.
Narayanan R (2016) Zika Virus Therapeutic Lead Compounds Discovery Using Chemoinformatics Approaches. MOJ Proteomics Bioinform 3(3): 00088.
Narayanan R (2016) Zika virus Therapeutics: Drug Targets and Repurposing Medicine from the Human Genome . MOJ Proteomics Bioinform 3(3): 00084.r
Narayanan R (2015) Druggable Vitiligo Genome: A Fast Track Approach to Take the Genome Wide Association to the Clinic. MOJ Proteomics Bioinform 2(3): 00050.
Narayanan R (2015) Druggable Cancer Secretome: Neoplasm-associated Traits. Cancer Genomics and Proteomics 12: 119-132.
Narayanan R (2015) Druggableness of the Ebola Associated Genes in the Human Genome: Chemoinformatics Approaches. MOJ Proteomics Bioinform 2(2): 00046.
Delgado AP, Chapado M, Brandao P, Hamid S and Narayanan R (2015) Atlas of the Open Reading Frames in human diseases: Dark Matter of the human genome. MOJ Proteomics Bioinform 2(1): 00036
Narayanan R (2015) Phenome-Genome association studies of pancreatic cancer: New targets for therapy and diagnosis. Cancer Genomics Proteomics 12: 9-20
Narayanan R (2014) Ebola-Associated Genes in the Human Genome: Implications for Novel Targets. MOJ Proteomics Bioinform 1(5): 00032
Narayanan R (2014) Neurodegenerative Diseases: Phenome to Genome Analysis. MOJ Proteomics Bioinform 1(6): 00033
Delgado AP, Hamid S, Brandao P, and Narayanan R (2014a). A Novel Transmembrane Glycoprotein Cancer Biomarker Present in the X Chromosome. Cancer Genomics Proteomics. Mar-Apr; 11 (2):81-92
Delgado AP, Brandao P, Chapado M, Hamid S and Narayanan R (2014b). Open reading frame associated with the dark matter of the human genome. Cancer Genomics and Proteomics. 11: 201-214
Delgado AP, Brandao P and Narayanan R (2014 c). Diabetes Associated Genes from the Dark Matter of the Human Proteome. MOJ Proteomics Bioinform 1(4) :00020
Narayanan R (2015). Noncoding RNAs: The Fourth Dimension of the Human Genome. MOJ Proteomics BioinformJ 2(2): 00043.
Narayanan R (2015). Electronic Health Records in the Genomics Era: Impact of Clinical Genomics. MOJ Proteomics Bioinform 2(3): 00045.
Narayanan R and Van De Ven WJM (2014) Transcriptome and Proteome Analysis: A Perspective on Correlation. MOJ Proteomics Bioinform 1(5): 00027.
Narayanan R (2014) Healthy Genome: A Myth or A Paradigm Shift in
Bioinformatics Research? MOJ Proteomics Bioinform 1 (4): 00023.
Narayanan R (2014) The Next Horizon in Proteomics and Genomics Research. MOJ Proteomics Bioinform 1(1): 00006.
Michael Slavik, Xingquan Zhu, Imad Mahgoub, Taghi Khoshgoftaar, and Ramaswamy Narayanan. Hand book on Data Intensive Computing: A Biomedical Case Study in Gene Selection and Filtering? Data intensive computing. Ed. B. Furht, Pages 563-580, Springer Science and Business Media, New York, 2011.
Abu HM Kamal, Xingquan Zhu, Abhijit Pandya, Sam Hsu and Ramaswamy Narayanan. Feature selection for datasets with imbalanced class distributions. Int. J. Soft. Eng. Knowl. Eng. 20, 113 (2010).
Delgado AP, Brandao P and Narayanan R (2013). Mining the dark matter of the cancer proteome for novel biomarkers. Current Cancer Therapy Reviews, 9, 1-13 1W
Kanezaki R, Toki T, Xu G, Narayanan R, Ito E. Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5. : Tohoku J Exp Med. 209:169-80. 2006.
Aleman MJ, DeYoung, MP, Tress, M, Keating, P, Perry, G and Narayanan, R. Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. Proc Natl Acad Sci USA 2005 Sep6;102(36:127650-70. Epub 2005 Aug 29.
DeYoung MP, Damania H, Scheurle D, Zylberberg C and Narayanan R: Bioinformatics based discovery of a novel factor with apparent specificity to colon cancer. In Vivo, 16:239-248,2002
DeYoung MP, Scheurle D, Damania H, Zylberberg C and Narayanan R: Down’s Syndrome-Associated Single Minded Gene As A Novel Tumor Marker Anticancer Research, 22: 3149-3158, 2002
DeYoung MP, Tress M, and Narayanan R: Identification of Down’s Syndrome Critical Locus gene SIM2 as a novel drug therapy target for solid tumors. Proc. Natl. Acad. Sci. USA 100: 4760-4765, 2003. Also see GNN news and TIPS review 2003, 24:10:508-510
DeYoung MP, Tress M, and Narayanan R: Down’s syndrome associated Single Minded gene 2 as a pancreatic cancer drug therapy target. Cancer Letters 200/1: 25-31, 2003
Rameshwar P, Narayanan R, Qian J, Denny TN, Colon C, Gascon P: NF-kappaB as a Central Mediator in the Induction of TGF-beta in Monocytes from Patients with Idiopathic Myelofibrosis: An Inflammatory Response Beyond the Realm of Homeostasis. J Immunol. 165(4):2271-2277, 2000.
Naz S, Kerr RG and Narayanan.R: New antiproliferative epoxysecosterols from pseudopterogorgia americana. Tetrahedron Lett. 41:6035-6040,2000.
Goldberg GS, Bechberger JF, Tajima Y, Merritt M, Omori Y, Gawinowicz MA, Narayanan R, Tan Y, Sanai Y, Yamasaki H, Naus CC, Tsuda H, Nicholson BJ. Connexin 43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells. Cancer Res 2000 ;60(21):6018-26
Elek J, Pinzon W, Park KH, and Narayanan R: Relevant genomics of neurotensin receptor in cancer. Anticancer Res. 20:53-58, 2000.
Elek J, Park KH, and Narayanan R: Microarray-based expression profiling in prostate tumors. In Vivo 14:173-182, 2000.
Scheurle D, Jahanzeb M, Aronsohn RS, Watzck L, and Narayanan R: HER-2/neu expression in archival non-small cell lung carcinomas using FDA-approved HercepTest. Anticancer.Res. 20:2091-2096,2000.
Scheurle D, DeYoung MP, Binninger DM, Page H, Jahanzeb M, and Narayanan R: Cancer gene discovery using digital differential display. Cancer Res, 60:4037-4043, 2000.
Ozen M, Imam SA, Datar RH, Multani AS, Narayanan R, Chung LW, von Eschenbach AC, and Pathak S: Telomeric DNA: marker for human prostate cancer development? Prostate 36: 264-271, 1998.
Ramakrishnan S, Eppenberger U, Mueller H, Shinkai Y, and Narayanan R: Expression profile of the putative catalytic subunit of telomerase gene. Cancer Res 58: 622-625, 1998.
Sokoloski JA, Narayanan R, and Sartorelli AC: Enhancement by antisense oligonucleotides to NF-kB of the differentiation of HL-60 promyelocytic leukemia cells induced by vitamin D3. Cancer Lett 125: 157-164, 1998.
Hsiao R, Sharma HW, Ramakrishnan S, Keith E, and Narayanan R: Telomerase activity in endothelial cells. Anticancer Res 17: 827-832, 1997.
Narayanan R: Harnessing the power of antisense for combination chemotherapy. J Natl Cancer Inst 89: 107-109, 1997.
Ramakrishnan S, Sharma HW, Farris AD, Kaufman KM, Harley JB, Collins K, Pruijn GJ, Van Venrooij WJ, Martin ML, and Narayanan R: Characterization of human telomerase complex. Proc Natl Acad Sci USA 94: 10075-10079, 1997.
Eckstein F, Krieg AM, Stein CA, Agarawal S, Beaucage S, Cook PD, Crooke S, Gait MJ, Gewertz A, Helene C, Miller P, Narayanan R, Nicolin A, Nielsen P, Ohtsuka E, Seliger H, Stec W, Tidd D, Wagner R, and Zon J: On the quality control of antisense oligonucleotides. Antisense Nucleic Acid Drug Dev 6: 149, 1996.
Gibson LF, Piktel D, Narayanan R, Nunez G, and Landreth KS: Stromal cells regulate bcl-2 and bax expression in pro-B cells. Exp Hematol 24: 628-637, 1996.
Khaled Z, Benimetskaya L, Zeltser R, Khan T, Sharma HW, Narayanan R, and Stein CA: Multiple mechanisms may contribute to the cellular anti-adhesive effects of phosphorothioate oligodeoxynucleotides. Nucleic Acids Res 24: 737-745, 1996.
Narayanan R and Akhtar S: Antisense therapy of cancer. Curr Opin Oncol 8: 509-515, 1996.
Sharma HW, Perez JR, Higgins-Sochaski KA, Hsiao R, and Narayanan R: Transcription factor decoy approach to decipher the role of NF-kB in oncogenesis. Anticancer Res 16: 61-70, 1996.
Sharma HW, Hsiao R, and Narayanan R: Telomerase as a potential molecular target to study G-quartet phosphorothioates. Antisense Nucleic Acid Drug Dev 6: 3-7, 1996.
Sharma HW and Narayanan R: The NF-kB transcription factor in oncogenesis. Anticancer Res 16: 589-596, 1996.
Sharma HW, Maltese JY, Zhu X, Kaiser HE, and Narayanan R: Telomeres, telomerase and cancer: Is the magic bullet real? Anticancer Res 16: 511-516, 1996
Zhu X, Kumar R, Mandal M, Sharma N, Sharma HW, Dhingra U, Sokoloski JA, Hsiao R, and Narayanan R: Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc Natl Acad Sci USA 93: 6091-6095, 1996.
Goldring CE, Narayanan R, Lagadec P, and Jeannin JF: Transcriptional inhibition of the inducible nitric oxide synthase gene by competitive binding of NF-kB/Rel proteins. Biochem Biophys Res Commun 209: 73-79, 1995.
Lin KI, Lee SH, Narayanan R, Baraban JM, Hardwick JM, and Ratan RR: Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B. J Cell Biol 131(5):1149-1161, 1995.
Maltese JY, Sharma HW, Vassilev L, and Narayanan R: Sequence context of antisense RelA/NF-kB phosphorothioates determines specificity. Nucleic Acids Res 7: 1146-1151, 1995.
Sharma HW, Sokoloski JA, Perez JR, Maltese JY, Sartorelli AC, Stein CA, Nichols CG, Khaled Z, Telang NT, and Narayanan R: Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci USA 92: 12343-12346, 1995.
Sharma HW, Higgins-Sochaski KA, Perez JR, and Narayanan R: A DNA motif present in aV integrin promoter exhibits dual binding preference to distinct transcription factors. Anticancer Res 15: 1857-1868, 1995.
Sharma HW and Narayanan R: The therapeutic potential of antisense oligodeoxynucleotides. BioEssays 17: 1055-1063, 1995.
Narayanan R: Antisense therapy of cancer. In Vivo 8: 787-794, 1994.
Perez JR, Higgins-Sochaski KA, Maltese JY, and Narayanan R: Regulation of adhesion and growth of fibrosarcoma cells by NF-kB relA involves transforming growth factor á. Mol Cell Biol 14: 5326-5332, 1994.
Perez JR, Li Y, Stein CA, Majumder S, van Oorschot A, and Narayanan R: Sequence independent induction of Sp1 transcription factor by phosphorothioate oligodeoxynucleotides. Proc Natl Acad Sci USA 91: 5957-5961, 1994.
Sarmiento U, Perez JR, Becker JM, and Narayanan R: In vivo toxicologic effects of rel A antisense phosphorothioates in CD-1 mice. Antisense Res Dev 4: 99-107, 1994.
Stein CA and Narayanan R: Antisense oligonucleotides. Curr Opin Oncol 6: 587-594, 1994.
Chen LL, Narayanan R, Hibbs MS, Benn PA, Clawson ML, Lu G, Rhim JS, Greenberg B, and Mendelsohn J: Altered epidermal growth factor signal transduction in activated ha-ras-transformed human keratinocytes. Biochem Biophys Res Commun 193: 167-174, 1993.
Higgins KA, Perez JR, Coleman TA, Dorshkind K, McComas WA, Sarmiento UM, Rosen CA, and Narayanan R: Antisense inhibition of the p65 subunit of NF-kB blocks tumorigenicity and causes tumor regression. Proc Natl Acad Sci USA 90: 9901-9905, 1993.
McIntyre KW, Lombard-Gillooly K, Perez JR, Kunsch C, Sarmiento UM, Larigan JD, Landreth KS and Narayanan R: A sense phosphorothioate oligonucleotide directed to the initiation codon of transcription factor NF-kB p65 causes sequence-specific immune stimulation. Antisense Res Dev 3: 309-322, 1993.
Narayanan R, Higgins KA, Perez JR, Coleman TA, and Rosen CA: Evidence for differential functions of the p50 and p65 subunits of NF-kB using a cell adhesion model. Mol Cell Biol 13: 3802-3810, 1993.
Sokoloski JA, Sartorelli AC, Rosen CA, and Narayanan R: Antisense oligonucleotides to the p65 subunit of NF-kB block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes. Blood 82: 625-632, 1993.
Billips LG, Petitte D, Dorshkind K, Narayanan R, Chiu CP, and Landreth KS: Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis. Blood 79: 1185-1192, 1992.
Henderson AJ, Narayanan R, Collins L, and Dorshkind K: Status of kappa L chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells. J Immunol 149: 1973-1979, 1992.
Landreth KS, Narayanan R, and Dorshkind K: Insulin-like growth factor-I regulates pro-B-cell differentiation. Blood 80: 1207-1212, 1992.
Lawlor K and Narayanan R: Persistent expression of the tumor suppressor gene DCC is essential for neuronal differentiation. Cell Growth Differen 3: 609-616, 1992.
Narayanan R, Schaapveld RQ, Cho KR, Vogelstein B, Tran PB, Osborne MP, and Telang NT: Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts. Oncogene 7: 553-561, 1992.
Narayanan R, Klement JF, Ruben SM, Higgins KA, and Rosen CA: Identification of a naturally occurring transforming variant of the p65 subunit of NF-kB. Science 256: 367-370, 1992.
Ruben SM, Narayanan R, Klement JF, and Rosen CA: Functional characterization of the NF-kB p65 transcriptional activator and an alternatively spliced derivative. Mol Cell Biol 12: 444-454, 1992.
, Canada Foundation for Innovation; 2002 - 2000
, National Cancer Institute, Kimmel Cancer Center; 2000 - 2000
Antisense and Gene Therapy, National Institutes of Health; 1996 - 1996
Apoptosis, National Cancer Institute; 1995 - 1995
Breast Cancer Research, United States Department of Defense; 1995 - 1995
; Anderson Cancer Center; 1994
; Karolinska Institute; 1994
; University of Utrecht; 1994
; National Cancer Institute; 1994
; University of Nijmegen; 1994
; First International Symposium on Bioinformatics; ; 1997
; Pittsburg Cancer Center; 1993
; Vermont Cancer Center; 1993
; Mary Babb Randolf Cancer Cente; 1993
; Strang-Cornell Cancer Prevention Center; 1993
; Hybridon, Inc.; 1995
; Washington University; 1995
; Aston University; 1995
; University of Medicine and Dentistry of New Jersey; 1995
; Human Genome Sciences; 1995
; Sylvester Cancer Center, University of Miami; 1999
; First International Symposium on Bioinformatics; Michigan Cancer Foundation; 1997
; First International Symposium on Bioinformatics; Aston University; 1997
; University of Medicine and Dentistry of New Jersey; 1991
; College of Physicians and Surgeons; 1996
; Thomas Jefferson University; 1996
; Tokyo Institute of Technology; 1996
Year: | 2016 |
Link Address: | https://www.medchemnet.com/users/5610-stella-bennett/videos/5964-video1 |
Keywords: | Zika; Drug like compounds; Chemoinformatics |
Source: | upload |
Duration: | 00:12:25 |
Year: | 2014 |
Link Address: | http://www.iiar-anticancer.org/conference/wp-content/uploads/congress_video/6_oct/room_F/Narayanan/Narayanan.html |
Keywords: | Dark matter: ORF: Cancer markers; Druggable genes; eQTL; ; |
Source: | upload |
Duration: | 00:26:13 |
777, Glades Road SC 216 http://biology.fau.edu/directory/narayanan/index.php http://www.researchgate.net/profile/Ramaswamy_Narayanan2 Boca Raton, FL 33431