Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by degeneration of motor neurons in the spinal cord and brain. Increasing evidence shows autoimmune mechanisms likely promote disease progression. Human umbilical cord blood (hUCB) derived plasma is rich in cytokines and growth factors that are required for growth and survival of cells during hematopoiesis. hUCB plasma attenuated the hyperactive response (Group III) and potentiated the normal response in Group I ALS patients, but did not alter that of the non-responders to PHA (Group II). The elevated activity of caspase 3/7 observed in the MNCs from ALS patients was significantly reduced by hUCB plasma treatment. The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggest that the use ofhUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients. (PDMA), polyacrylic acid (PAA), PE and graphene based materials to show superior contraction and expansion response with moist air. The synthesized PPY films have shown more flexibility with luster (state or quality of shinning by reflection of light). The free standing PPY—composite film responds to moist air by freely moving forward and backward, indicating that it can be easily integrated in toys. Our film can also be used as humidity sensor, capacitor, and robotic works.
A method of treating neurodegenerative diseases using hUCB plasma is presented herein. hUCB plasma attenuated the hyperactive response (Group III) and potentiated the normal response in Group I ALS patients, but did not alter that of the non-responders to PHA (Group II). The elevated activity of caspase 3/7 observed in the MNCs from ALS patients was significantly reduced by hUCB plasma treatment. The ability ofhUCB plasma to modulate the mitogen cell response and reduce caspase activity suggest that the use ofhUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients. hUCB plasma was shown to increase therapeutic efficacy ofMNCs as well as decrease apoptosis of MNCs. The cytokine profile of hUCB plasma supports its usefulness as a sole therapeutic as well as an additive to MNCs.Neuroscience, Medical
