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Margaret James

Professor & Chair, Medicinal Chemistry

PH-MEDICINAL CHEMISTRY | COLLEGE-PHARMACY

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Background
Publications
Activities
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Research Terms & Keywords

Research Terms

Medicinal Chemistry Toxicology

Keywords

Drug Metabolism Enzymes Xenobiotics

Research Projects

Ends

Title

08-2021

Developmental Pharmacology of Mitochondrial and Cytosolic GSTZ1 Developmental Pharmacology of Mitochondrial and Cytosolic GSTZ1

NATL INST OF HLTH NIGM

08-2019

Molecular and Genomic Approaches in Alleviating Environmental Pollution Molecular and Genomic Approaches in Alleviating Environmental Pollution

EGYPTIAN CULTURAL AND EDU BU

08-2019

Molecular and Genomic Approaches in Alleviating Environmental Pollution Molecular and Genomic Approaches in Alleviating Environmental Pollution

US AGCY INTL DE

04-2017

Health Impact of Deepwater Horizon Spill in Eastern Gulf Coast Communities Health Impact of Deepwater Horizon Spill in Eastern Gulf Coast Communities

NATL INST OF HLTH NIEH

08-2016

Developmental Pharmacology of Cytosolic and Mitochondrials GSTZ1-1/MAAI Developmental Pharmacology of Cytosolic and Mitochondrials GSTZ1-1/MAAI

NATL INST OF HLTH NIGM

06-2015

Biomarkers of Exposure to Oil-related Chemicals in Gulf Biomarkers of Exposure to Oil-related Chemicals in Gulf

UNIVERSITY OF SOUTH ALABAMA

11-2014

Modulation of Steroid Sulfonation by Celecoxib-like Drug Modulation of Steroid Sulfonation by Celecoxib-like Drug

UF FO

01-2014

Fetal Endocrine Disruption by Triclosan Fetal Endocrine Disruption by Triclosan

NATL INST OF HLTH NIEH

04-2013

Inhibition of Estrogen Sulfotransferase as a Risk to Inhibition of Estrogen Sulfotransferase as a Risk to

UF DSR OPPORTUNITY FUN

03-2013

Effect of Deepwater Horizon Oil Spill on Fish Communitie Effect of Deepwater Horizon Oil Spill on Fish Communitie

UNIV OF SOUTH FLORID

02-2012

Pharmacology of Trichloroethylene Metabolites Pharmacology of Trichloroethylene Metabolites

NATL INST OF HLT

08-2011

Modulation of Steroid Sulfation by Celecoxib-like Drugs Modulation of Steroid Sulfation by Celecoxib-like Drugs

NATL INST OF HLTH NC

05-2010

DICHLOROACETATE KINETICS, METABOLISM AND TOXICOLOGY DICHLOROACETATE KINETICS, METABOLISM AND TOXICOLOGY

NATL INST OF HLT

06-2007

Health Effects of Chlorinated Compounds Health Effects of Chlorinated Compounds

UF DSR OPPORTUNITY FUN

05-2007

HEALTH EFFECTS OF CLORINATED COMPOUNDS HEALTH EFFECTS OF CLORINATED COMPOUNDS

NATL INST OF HLTH NIEH

06-2006

The Role of Quinols in Estrogen Neuroprotection. The Role of Quinols in Estrogen Neuroprotection.

UNIV OF NORTH TEXAS HLTH SCIENCE CT

12-2005

INDIRECT COST RETURNS/SALARY INDIRECT COST RETURNS/SALARY

UF RESEARCH FOU SALARY EXPENSE TRANSFER

06-2005

PROFESSORSHIP AWARD PROGRAM PROFESSORSHIP AWARD PROGRAM

UF RESEARCH FO

10-2003

HEALTH EFFECTS OF CHLORINATED COMPOUNDS: HISTOLOGY HEALTH EFFECTS OF CHLORINATED COMPOUNDS: HISTOLOGY

NATL INST OF HLTH NIEH

11-2001

BIOAVAILABILITY and METABOLISM OF DIETARY CARCINOGENS BIOAVAILABILITY and METABOLISM OF DIETARY CARCINOGENS

NATL INST OF HLTH NIEH

11-2001

BIOAVAILABILITY AND METABOLISM OF DIETARY CARCINOGENS BIOAVAILABILITY AND METABOLISM OF DIETARY CARCINOGENS

NATL INST OF HLTH NIEH

03-2001

WORKSHOP - HEALTH EFFECTS OF CHLORINATED COMPOUNDS WORKSHOP - HEALTH EFFECTS OF CHLORINATED COMPOUNDS

NATL INST OF HLTH NIEH

10-2000

BIOLOGICAL EVALUATION AGREEMENT BIOLOGICAL EVALUATION AGREEMENT

DUPONT C

06-2000

AQUATIC TOXICOLOGY AQUATIC TOXICOLOGY

UF DSR OPPORTUNITY FUN

03-2000

WORKSHOP ON PROBABILISTIC RISK ASSESSMENT WORKSHOP ON PROBABILISTIC RISK ASSESSMENT

NATL INST OF HLTH NIEH

03-2000

ANALYTICAL CORE A: HEALTH EFFECTS OF CHLORINATED COMPOU ANALYTICAL CORE A: HEALTH EFFECTS OF CHLORINATED COMPOU

NATL INST OF HLTH NIEH

03-2000

HEALTH EFFECTS OF CHLORINATED COMPOUNDS HEALTH EFFECTS OF CHLORINATED COMPOUNDS

NATL INST OF HLTH NIEH

06-1999

DICHLOROACETATE KINETICS, METABOLISM AND TOXICOLOGY DICHLOROACETATE KINETICS, METABOLISM AND TOXICOLOGY

NATL INST OF HLTH NIAA

03-1998

ADMINISTRATIVE CORE: HEALTH EFFECTS OF CLORINATED COMPO ADMINISTRATIVE CORE: HEALTH EFFECTS OF CLORINATED COMPO

NATL INST OF HLTH NIEH

Degrees

D.Sc., Toxicology

University of London ▪ 1993
Ph.D., Organic Chemistry

University of London, UK ▪ 1972
B.S., Chemistry

University College London ▪ 1969

Awards & Honors

Fellow

American Association for the Advancement of Science ▪ 2011

Publications

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Li, W., James, M.O., MacKenzie, S., Liu, C., Calcutt, N.S. and Stacpoole, P.W. Mitochondrion as a novel site of dichloroacetate biotransformation. J. Pharmacol. Exp. Therap. 336: 1-8, 2011 DOI:10.1124/jpet.110.173195 PMID 20884751

James, M.O., Marth, C.J. and Rowland-Faux, L. Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine. Aquatic Toxicology 124-125: 72-82, 2012 doi:10.1016/j.aquatox.2012.07.009

Li, W., Gu, Y., James, M.O., Hines, R.N., Simpson, P. Langaee, T. and Stacpoole, P.W. Prenatal and postnatal expression of glutathione transferase zeta 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate. Drug Metabolism and Disposition, 40, 232-239, 2012. PMID 22028317

James, M.O. and Stacpoole, P.W. Pharmacogenetic considerations with dichloroacetate dosing. Pharmacogenomics, 17(7):743-53, 2016 PMID: 27143230

James, M.O. and Ambadapadi, S. Interactions of cytosolic sulfotransferases with xenobiotics. Drug Metabolism Reviews 45(4):401-414,2013. PMID: 24188364

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Memberships

American Chemical Society, Member; 1984 - 2022

Society of Toxicology, Member; 1984 - 2022

American Association for the Advancement of Science, Pharmaceutical Science, Member; 1984 - 2022

American Society of Pharmacology and Experimental Therapeutics, Member; 1984 - 2022

International Society for the Study of Xenobiotics, Member; 1981 - 2022

Peer Review Positions

XNDA Study Section, NIH; 2019 - 2023

Chemico-Biological Interactions, Journal; 2005 - 2022

National Center for Research Resources, NIH; 2003 - 2003

Drug Metabolism and Disposition, ASPET; 1995 - 2022

Aquatic Toxicology, Elsevier; 1993 - 2022

Environmental Health Sciences, NIH; 1991 - 1995

Professional Presentations

Ontogeny of human glutathione transferases; Lecture; International Society for the Study of Xenobiotics; 2011

Structure and Function of Glutathione Transferases; Gordon Conference Drug Metabolism; Gordon Research Conferences; 2018

Biomarkers of exposure to polycyclic aromatic hydrocarbons in Gulf of Mexico reef fishes; PRIMO 18, Trondheim, Norway; Pollutant Responses in Marine Organisms, ; 2015

Other Professional Activities

Member of working group to examine the potential carcinogenicity of polychlorinated biphenyls at the International Agency for Research on Cancer (IARC), February 2013

Co-Investigator Network

Inactive Expert

Margaret James

Professor & Chair, Medicinal Chemistry

PH-MEDICINAL CHEMISTRY | COLLEGE-PHARMACY

Research Terms & Keywords

Research Projects

Degrees

Awards & Honors

Publications

Memberships

Peer Review Positions

Professional Presentations

Other Professional Activities

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