Ronald Mandel

1.      Gombash, S.E, Lipton, J.W., Collier, T.J., Madhavan, L., Steece-Collier, K, Cole-Strauss, A., Terpstra, B.T., Spieles-Engemann, A.L., Daley, B.F. Wohlgenent, S.L., Thompson, V.B, Manfredsson, F.P., Mandel, R.J., and Sortwell, C.E. Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model of Parkinson’s disease. Molecular Therapy 20 (2012) 544-554.

2.      Tebbenkamp, A.T.N., Green, C., Xu, G., Denovan-Wright, E.M., Rising, A.C., Fromholt, S.E., Slunt, H.H., Swing, D., Mandel, R.J., Tessarolla, L., Borchelt, D.R.  Transgenic mice expressing caspase-6 derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. Human Molecular Genetics 20 (2011) 2770-2782.

3.      Rising, A.C., Xu, J., Carlson, A., Napoli, V.V., Denovan-Wright, E.M, and Mandel, R.J. Longitudinal behavioral, cross-sectional transcriptional, and histopathological characteristics of a knock-in mouse model of Huntington’s disease with 140 CAG repeats. Experimental Neurology 228 (2011) 173-182.

4.      Gorbatyuk, O. S., Li, S.., Nguyen, F.N., Kondrikova, G., Sullivan, L.F., Meyers, C., Chen, W., Nash, K., Manfredsson, F.P., Mandel, R.J., and Muzyczka, N.  Alpha synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral degeneration. Molecular Therapy 18 (2010) 1758-1768.

5.      Gorbatyuk, O.S., Nash, K., Li, Gorbatyuk, M., Lewin, A.S., Sullivan, F.S., Mandel, R.J., Chen, W., Meyers, C., and Muzyczka, N. In vivo alpha synuclein silencing via AAV mediated RNAi delivery. Molecular Therapy 18 (2010) 1450-1457.

6.      Dodiya, H.B., Kirik, D., Mandel, R.J., Bjorklund, T., Stansell, J., Bjorklund, A., and Kordower, J.H. Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates. Molecular Therapy 18 (2010) 589-597.

7.      Manfredsson, F.P, Burger, C., Rising, A.C., Zuobi-Hasona, K., Sullivan, L.F., Lewin, A.S., Huang, J., Piercefield, E., Muzyczka, N. and Mandel, R.J. Tight long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Molecular Therapy 17 (2009) 1857-1867.

8.      Bjorklund, T., Hall, H., Breysse, N., Soneson, C., Carlsson, T., Mandel, R.J., Carta, M., and Kirik, D. Optimization of continuous in vivo dopa production and studies of ectopic DA synthesis using rAAV5 vectors in parkinsonian rats. Journal of Neurochemistry 111 (2009) 355-367.

9.      Manfredsson^,, F.P., Tumer, N., Erdos, B., Landa, T., Broxson, C.S., Sullivan, L.F., Rising, A., Foust, K.D., Zhang,Y., Scarpace, P.J. and Mandel, R.J. Nigrostriatal GDNF over-expression induces robust weight loss in a rat model of age-related obesity. Molecular Therapy 17 (2009) 980-991.