Research Terms
Psychology Neurosciences Behavioral Neuroscience Neurophysiology
Keywords
Animal Models Behavioral Analysis In Vivo Neurophysiology Learning And Memory Neural Circuits Neuroscience Of Learning Spatial Navigation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423757/
https://onlinelibrary.wiley.com/doi/full/10.1002/hipo.22712
https://www.sciencedirect.com/science/article/pii/S1074742716300910?via%3Dihub
https://www.sciencedirect.com/science/article/pii/S0028390816301733?via%3Dihub
http://journal.frontiersin.org/article/10.3389/fphar.2015.00225/abstract
http://www.sciencedirect.com/science/article/pii/S0166432814005130
http://www.sciencedirect.com/science/article/pii/S0018506X14000956
http://www.sciencedirect.com/science/article/pii/S0960982213008257
Society for Neuroscience, Member; 1989 - present
Schizophrenia affects more than 20 million people worldwide, with approximately 3.5 million people diagnosed with schizophrenia in the United States. The condition is characterized by various symptoms that affect mental state, emotions, behaviors, and cognition. While antipsychotics are widely used to treat schizophrenia, most have limited therapeutic efficacy. Hence, there is an unmet need to develop new treatments.
Researchers at FAU propose repurposing an FDA-approved drug, chlorzoxazone (CZX), which can activate small conductance calcium-activated potassium (SK) ion channels and may be a promising therapeutic to treat attention and memory deficits associated with schizophrenia. Preclinical animal studies of schizophrenia show CZX significantly reduced memory deficits. Hence, CZX could be a promising treatment of cognitive symptoms in schizophrenic patients.
FAU is seeking partners to advance this technology into the marketplace through licensing or development partnerships.
