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Umesh K Jinwal
Assistant Professor

University of South Florida



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Recent Publications:

   1.    Gracia, L., Lora, G., and Jinwal, U.K* (2019) Role of Hsp90 interacting Molecular Chaperones on Tau and Aß Processing in Alzheimer’s Disease ­. Volume 20: Heat Shock Proteins in Neuroscience, Heat Shock Proteins Book series, Springer Nature Publishers Edited by: Prof. Dr. Alexzander A. A. Asea and Dr. Punit Kaur.  Accepted/ in press (*corresponding author). 

2.    Delic, V., Griffin,  J., Zivkovic, S., Zhang, Y., Phan, T.A., Chaput, D., Reynes, C., Dinh, V.B., Cruz, J., Cvitkovic, E., Placides, D., Frederic, E., Mirzaei, H., Stevens, S.M., Jinwal, U., Lee, D.C., Bradshaw, P.C. (2017) Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. NeuroMolecular Medicine,19, 322-344.


3.    Young, Z.T., Rauch J.N., Assimon, V.A., Jinwal, U.K., Ahn, M., Li, X., Dunyak, B.M., Ahmad, A., Carlson, G.A., Srinivasan, S.R., Zuiderweg, E.R., Dickey, C.A., Gestwicki, J.E. (2016) Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chemical Biology, 23, 1-10.


4.    Narayan, M., Seeley, K.W., Jinwal, U.K* (2016) Data from SILAC-based quantitative analysis of lysates from mouse microglial cells treated with Withaferin A (WA). Data in Brief, 7, 747-750 (*corresponding author).


5.    Narayan, M., Seeley, K.W., Jinwal, U.K* (2016) Identification of Apo B48 and other novel biomarkers in amyotrophic lateral sclerosis patient fibroblasts. Biomarkers in Medicine, 10, 453-462. (*corresponding author).


6.    Narayan, M., Kirouac, L., Chaput, D., Stevens, S., Padmanabhan, J., Jinwal, U.K* (2016) Identification of Novel Cdc37 Interacting Proteins and Pathways in Human Alzheimer’s Disease Brain Tissue using Mass Spectrometry. Journal of Data Mining in Genomics & Proteomics, 7:193. doi: 10.4172/2153-0602.1000193 (*corresponding author).


7.    Klionsky, D.J.,…..Jinwal, U.K., …..Zughaier, S.M. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12, 1-222.


8.    Narayan, M. and Jinwal, U.K* (2016) Cdc37: Implications in regulation of kinases and proteins linked to neurodegenerative and other diseases­. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Aging, Volume 10: Role of Autophagy in Therapeutic Applications, Edited by: M.A. Hayat, Elsevier. Chapter 9, pages 187-196 (*corresponding author).


9.    Narayan, M., Seeley, K.W., Jinwal, U.K* (2015) Identification and Characterization of Cellular Proteins Affected by Treatment with Withaferin A using a SILAC-based Proteomics Approach. Journal of Ethnopharmacology, 175, 86-92 (*corresponding author).


10.  Narayan, M., Peralta, D.A., Gibson, C., Zitnyar, A., Jinwal, U.K* (2015) An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug. Journal of Biotechnology, 207, 34-38 (*corresponding author).


11.  Narayan, M., Zhang, J., Braswell, K., Gibson, C., Zitnyar, A., Lee, D.C., Varghese-Gupta, S., Jinwal, U.K* (2015) Withaferin A regulates LRRK2 levels by interfering with the Hsp90-Cdc37 chaperone complex. Current Aging Science, 8, 259-65 (*corresponding author).


12.  Fontaine, S., Rauch, J.N., Nordhues, B.N., Assimon, V.A., Stothert, A., Jinwal, U.K , Sabbagh, J., Cheng, L., Stevens, S., Zuiderweg, E.R.P., Gestwicki, J.E., Dickey, C.A. (2015) Isoform Selective Inhibition of Constitutive Cytosolic Hsp70 Promotes Client Tau Degradation Through an Altered Co-chaperone Complement. The Journal of Biological Chemistry, 290, 13115-27.


13.  Martin, M.D., M., Laurent, C., Smith, C., Jinwal, U.K , Fontaine, S., April, D., Kent, S., Wojtas, L., Narayan, M., Gestwicki, J., Smith, G., Reitz, A., Baker, B., Dickey, C.A. (2015) Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. ACS Chemical Biology, 10, 1099-109.


14.  Jinwal, U.K , Groshev, A., Zhang, J., Grover, A., Sutariya, V.B. (2014) Preparation and Characterization of Methylene blue Nanoparticles for Alzheimer’s disease and other Tauopathies. Current Drug Delivery, 11, 541-50.


15.  Jinwal, U.K, Grover, A., Narayan, M., Hirani, A., Sutariya, V.B. (2014) Preparation and Characterization of MKT-077 Nanoparticles for brain-targeted treatment of Alzheimer’s disease and other Tauopathies. Pharmaceutical Nanotechnology, 2, 217-226.


16.  Braswell, K., Dickey, C.A. Jinwal, U.K* (2013) A commentary on: Modulating Molecular Chaperones Improves Sensory Fiber Recovery and Mitochondrial Function in Diabetic Peripheral Neuropathy. Experimental Neurology, 241C, 121-124 (*corresponding author).


17.  Jinwal, U.K, Koren, J. III, Dickey, C.A. (2013) Reconstructing the Hsp90/Tau Machine. Current Enzyme Inhibition, 9, 41-45.


18.  Totten, D.C., Vuong, M., Litvinova, O.V., Jinwal, U.K., Gulia-Nuss, M., Harrell II, R.A., Benes, H. (2013) Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes. Insect Molecular Biology, 22, 18-30.


19.  Abisambra, J.F. , Jinwal, U.K., Blair, L.J., O’Leary, J.C., Li, Q., Brady, S., Wang, L.,  Guidi, C., Zhang, B., Nordhues, B.A., Cockman, M., Suntharalingham, A.,  Li, P., Jin, Y., Atkins, C.A., Dickey, C.A. (2013) Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. The Journal of Neuroscience, 33, 9498-507. PMID 23719816.


20.  Jinwal, U.K., Akoury, E., Abisambra, J.F., O’Leary, J.C., Thompson, A. D., Blair, L., Jin, Y., Bacon, J., Bryce, N., Cockman, M.,  Zhang, J., Li, P.,  Zhang, B., Borysov, S., Vladimir, U., Biernat, J., Mandelkow, E., Gestwicki, J.E., Zweckstetter, M.,  Dickey, C.A. (2013) Imbalance of Hsp70 family variants fosters tau accumulation. The FASEB Journal, 27, 1450-59.


21.  Abisambra, J.F.*, Jinwal, U.K.*, Miyata, Y., Rogers, J., Blair, L., Li, X., Seguin, S.P., Wang, L., Jin, Y., Bacon, J., Brady, S., Cockman, M., Guidi, C., Zhang, J., Koren, J., Young, Z.T., Atkins, C.A., Zhang, B., Lawson, L.Y., Weeber, E.J., Brodsky, J.L.,  Gestwicki, J.E., Dickey, C.A.(2013) Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry, 74, 367-74. PMID 23607970 (* equal contribution).


22.  Miyata, Y., Li, X., Lee, H., Jinwal, U. K., Srinivasan, S., Seguin, S., Young, Z., Brodsky, J., Dickey, C. A., Duxin, S., Gestwicki, J. E. (2013) Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels. ACS Chemical Neuroscience, 4, 930-9. PMID: 23472668.


23.  Jinwal, U.K.*, J.H., Abisambra, J.F., Zhang, J., Dharia, S., O’Leary, J.C., Patel, T., Braswell, K., Jani, T., Gestwicki, J.E., Dickey, C.A.* (2012) Cdc37/ Hsp90 Complex disruption triggers an autophagic clearance cascade for TDP-43. The Journal of Biological Chemistry, 287, 24814-20. (*corresponding author).


24.  Kasiappan, R., Shen, Z., Tse, A.K-W,  Jinwal, U., Tang, J., Lungchukiet, P., Sun, Y., Kruk, P., Nicosia, S.V., Zhang, X., Bai, W. (2012) 1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498. The Journal of Biological Chemistry, 287, 41297-309.


25.  Miyata, Y., Rauch, J. N., Jinwal, U. K., Thompson, A. D., Srinivasan, S., Dickey, C. A., Gestwicki, J. E. (2012) Cysteine reactivity distinguishes redox sensing by the heat inducible and constitutive forms of heat shock protein 70 (Hsp70). Chemistry & Biology, 19, 1391-1399.


26.  Thompson, A. D., Scaglione, K.M., Presener, J., Gillies, A.T., Chinnaiyan, A., Paulson, H. L., Jinwal, U.*  K., Dickey, C. A.*, Gestwicki, J. E.* (2012) Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS Chemical Biology, 7, 1677-86 (*corresponding author).


27.  Suntharalingam, A., Abisambra, J.F., O’Leary,  J.C.,  Koren, J. III., Zhang, B., Joe, M.K., Blair, L.J., Hill, S.E.,  Jinwal, U.K., Cockman, M, Duerfeldt, A.S., Tomarev, S., Blagg, B.S.J., Lieberman, R.L., Dickey, C.A. (2012) Grp94 triage of mutant myocilin through ERAD subverts a more efficient autophagic clearance mechanism. The Journal of Biological Chemistry, 287, 40661-9.

28.  Calcul, L., Zhang, B., Jinwal, U.K., Dickey, C.A., Baker, B.J.  (2012) Natural products are a rich source of tau-targeting drugs for Alzheimer’s disease. Future Medicinal Chemistry, 4, 1751-61.


29.  Koren, J. III., Miyata, Y., Kiray, J., O’Leary, J.C., Nguyen, L., Guo, J., Blair, L.J.,  Jinwal, U.K., Cheng, J.Q., Gestwicki, J.E.,  Dickey, C.A. (2012) Rhodacyanine derivatives selectively targets cancer cells and overcomes tamoxifen resistance. PLoS ONE, 7, e35566, 1-8.


30.  Abisambra, J.F., Jinwal, U.K., Suntharalingam, A., Arulselvam, K. Brady, S., Cockman, M.S., Jin, Y., Zhang, B., Dickey, C.A. (2012) DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. Journal of Molecular Biology, 421, 653-61.


31.  Jinwal, U.K., Trotter, J.H., Abisambra, J.F., Vestal, G.D., Koren, J. III, Lawson, L.Y., Vestal, G.D., O’Leary,  J.C., Johnson, A.G., Jin, Y., Jones, J.R, Li, Q., Weeber, E.J. and Dickey, C.A. (2011) The Hsp90 kinase co-chaperone Cdc37 regulates tau stability. The Journal of Biological Chemistry, 286, 16976-83.


32.  Jinwal, U.K. and Dickey, C.A. (2011) Cell-based assays for regulators of Tau Biology. “Alzheimer’s disease and frontotemporal dementia”. Methods in molecular biology, volume 670, Part1, 93-108, Roberson, Erik D. (Ed.), The Humana Press.

33.  Koren, J. III, Jinwal, U.K., Davey, Z., Kiray, J., Aruselvam, K. and Dickey, C.A. (2011) Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Molecular Neurobiology, 44, 65-70.


34.  O’Leary, J.C., Dharia, S., Blair, L.J., Brady, S., Johnson, A.G., Peters, M., Cheung-Flynn, J., Cox, M. B., Erausquin, G., Weeber, E.J. Jinwal, U.K., and Dickey, C.A. (2011) A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS ONE, 6, e24840, 1-9.


35.  Trotter, J.H., Klein, M., Jinwal, U., Abisambra, J., Dickey, C., Tharkur, J., Masiulis, I., Ding, J., Locke, K., Rickman, C., Birch, D., Weeber, E.J. and Herz, J. (2011) ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. The Journal of Neuroscience, 31, 14413-23.


36.  Daily, J.L., Nash, K., Jinwal, U., Golde, T., Rogers, J., Peters, M.P., Burdine, R.D., Dickey, C., Banko, J.L., and Weeber, J.E. (2011) Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. PLoS ONE, 6(12):e27221.


37.  Evans, C.E., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E. (2011) Identification of dihydropyridines that reduce cellular tau levels. Chemical Communications, 47, 529-31.


38.  Rousaki, A., Miyata, Y., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E., and Zuiderweg, E.R.P. (2011)

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