Expert Profile

Charles Lockwood

Sr VP- Usf Health & Dean - Com

USF HEALTH | MORSANI COLLEGE OF MEDICINE

Research Terms & Keywords

Research Terms

Science

Research Projects

Ends

Title

03-2020

Cellular and Molecular Mediators of Zika Virus Replicati Cellular and Molecular Mediators of Zika Virus Replicati

12-2018

March of Dimes Prematurity Research Center Ohio Collabor March of Dimes Prematurity Research Center Ohio Collabor

12-2017

March of Dimes Prematurity Research Center Ohio Collabor March of Dimes Prematurity Research Center Ohio Collabor

06-2017

Tobacco Free Florida AHEC Cessation Program Tobacco Free Florida AHEC Cessation Program

12-2016

March of Dimes Prematurity Research Center Ohio Collabor March of Dimes Prematurity Research Center Ohio Collabor

12-2015

March of Dimes Prematurity Research Center Collaborative -Theme 4 March of Dimes Prematurity Research Center Collaborative -Theme 4

06-2015

March of Dimes Prematurity Research Center Ohio Collaborative Theme 4 March of Dimes Prematurity Research Center Ohio Collaborative Theme 4

06-2014

USF Area Health Education Center Tobacco Training & Cessation Program USF Area Health Education Center Tobacco Training & Cessation Program

Degrees

MHCM, Health care management

Harvard School of Public Health ▪ 2009
MD, Medicine

University of Pennsylvania ▪ 1981
B.Sc., Biology

Brown University ▪ 1977

Awards & Honors

President

American Gynecological and Obstetrical Society ▪ 2018
Lifetime Achievement Award

Society for Maternal Fetal Medicine ▪ 2017
Fellow

American Association for the Advancement of Science ▪ 2016
SRI/Pardi's President's Distinguished Scientist Award

Society for Reproductive Sciences ▪ 2013
Fellow

National Academy of Medicine ▪ 2010
Member

Alpha Omega Alpha ▪ 1998
Member

Sigma Xi ▪ 1977

Publications

295. Casale TB, Teng MN, Morano JP, Unnasch T, Lockwood CJ. Zika Virus: An Emerging Infectious Disease with Serious Perinatal and Neurologic Complications. J Allergy Clin Immunol. 2017 Dec 19. pii: S0091-6749(17)32916-0. doi: 10.1016/j.jaci.2017 .11.029. [Epub ahead of print] PMID: 29273403

Kumar D, Moore RM, Mercer BM, Mansour JM, Mesiano S, Schatz F, Lockwood CJ, Moore JJ. In an in-vitro model using human fetal membranes, 17-α hydroxyprogesterone caproate is not an optimal progestogen for inhibition of fetal membrane weakening. Am J Obstet Gynecol. 2017 Oct 12. pii: S0002-9378(17)31186-9. doi: 10.1016/j.ajog.2017.10.004. [Epub ahead of print]
Arlier S, Murk W, Guzeloglu-Kayisli O, Semerci N, Larsen K, Tabak MS, Arici A, Schatz F, Lockwood CJ, Kayisli UA. The extracellular signal-regulated kinase 1/2 triggers angiogenesis in human ectopic endometrial implants by inducing angioblast differentiation and proliferation. Am J Reprod Immunol. 2017; 78. doi: 10.1111/aji.12760. Epub 2017 Sep 16.
Nwabuobi C, Arlier S, Schatz F, Guzeloglu-Kayisli O, Lockwood CJ, Kayisli UA. hCG: Biological Functions and Clinical Applications. Int J Mol Sci. 2017 Sep 22;18(10). pii: E2037. doi: 10.3390/ijms18102037. Review.
Shapiro JP, Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Huang SJ, Arlier S, Larsen K, Fadda P, Schatz FR, Lockwood CJ. Thrombin impairs human endometrial endothelial angiogenesis; implications for progestin-only contraceptive-induced abnormal uterine bleeding. Contraception. 2017 Jun;95(6):592-601. doi: 10.1016/j.contraception.2017.04.001. Epub 2017 Apr 19.PMID: 28433626
Guzel E, Arlier S, Guzeloglu-Kayisli O, Tabak MS, Ekiz T, Semerci N, Larsen K, Schatz F, Lockwood CJ, Kayisli UA. Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology. Int J Mol Sci 2017 April 8; 18(4). pii E792. doi: 10.3390/ijms 18040792 PMID: 28397763
Hu Z, Cheng J, Xu J, Ruf W, Lockwood CJ. Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy. Angiogenesis. 2017 Feb;20(1):85-96. doi: 10.1007/s10456-016-9530-9. Epub 2016 Nov 2.PMID: 27807692
Chedraui P, Solis EJ, Perez-Lopez FR, Schatz F, Kayisli U, Escobar GS, Loja-Chango R, Hidalgo L, Lockwood, CJ. Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia. J Perinat Med 2016; 44(3); 291-294. PMID: PMC25741937.
Mhatre MV, Potter JA, Lockwood CJ, Krikun G, Abrahams VM. Thrombin augments LPS-induced human endometrial endothelial cell inflammation via PAR1 activation. Am J Reprod Immunol. 2016 Apr 24. doi: 10.1111/aji.12517. [Epub ahead of print] PMID: 27108773
Schatz F, Guzeloglu-Kayisli O, Arlier S, Kzayisli UA, Lockwood CJ. The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Hum Reprod Update 2016 June; 22(4):497-515, doi: 10.1093/humupd/dmw004 PMID: 26912000.
Guzeloglu-Kayisli O, Kayisla UA, Basar M, Semerci N, Schatz F, Lockwood CJ. Progestins upregulate FKBP51 expression in human endometrial stromal cells to induce functional progesterone and glucocorticoid withdrawal: implications for contraceptive-associated abnormal uterine bleeding. PLoS One 2015 Oct 5; 10(10):e0137855. doi: 10.1371/journal.pone.0137855. eCollection 2015 PMCID: PMC 4593551.
Ibrahim SA, Ackerman WE 4^th, Summerfield TL, Lockwood CJ, Schatz F, Kniss DA. Inflammatory gene networks in term human decidual cells define a potential signature for cytokine-mediated parturition. Am J Obstet Gynecol 2016; 214; 284.e1-47, pii: S0002-9378(15)01023-6. doi: 10.1016/j.ajog.2015.08.075. PMID: 26348374.
Funghi L, Damiani F, Yen CF, Lee CL, Lombardi A, Schatz F, Lockwood CJ, Marcolongo P, Petraglia F, Arcuri F. Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia. Mol Cell Endocrinol 2016 Aug 18;437:163-170. Doi: 10.1016/j.mce.2016.08.023 PMID: 27544778.
Ackerman WE, Summerfield TL, Mesiano S, Schatz F, Lockwood CJ, Kniss, DA. Agonist-dependant down-regulation of progesterone receptors in human cervical stromal fibroblast. Reprod Sci 2015 Aug 4, pii: 1933719115597787 PMID: 26243545.
Schatz F, Guzeloglu-Kayisli O, Basar M. Buchwalder LF, Ocak N, Guzel E, Guller S, Semerci N, Kayisli UA, Lockwood CJ. Enhanced human decidual cell-expressed FKBP51 may promote labor-related functional progesterone withdrawal. Am J Pathol 2015 Jul 21. pii:S0002-9440(15)00361-2 doio 10.1016/j.ajpath 2015.04.014 [Epub ahead of print] PMID: PMC 26207680.
Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Basar M, Buchwalder LF, Buhimschi CS, Buhimschi IA, Acuri F, Larsen K, Huang JS, Schatz F, Lockwood CJ. Mechanisms of chorioamnionitis-associated preterm birth: Interleuken 1β inhibits progesterone receptor expression in decidual cells. J Pathol. 2015 Jul 14. doi: 10.1002/path.4589 [Epub ahead of print] PMID: 26175191.
Kumar D, Springel E, Moore RM, Mercer BM, Philipson E, Mansour JM, Mesiano S, Schatz F, Lockwood CJ, Moore JJ. Progesterone inhibits in vitro fetal membrane weakening. Am J Obstet Gynecol. 2015 June 10. Pii: S0002-9378(15)00597-9. doi: 10.1016/j.ajog.2015.06.014. [Epub ahead of print] PMID: 26070709.
Chen CP, Piao L, Chen X, Yu J, Masch R, Schatz F, Lockwood CJ, Huang SJ. Expression of interferon y by decidual cells and natural killer cells at the human implantation site: Implications for preeclampsia, spontaneous abortion, and intrauterine growth restriction. Reprod Sci 2015 May 11. Pii:1933719115585148 [Epub ahead of print] PMID: PMC25963913.
Guzel E, Buchwalder L, Basar M, Kayisli U, Ocak N, Bozkurt I, Lockwood CJ, Schatz F. Effects of tibolone and its metabolites on prolactic and insulin-like growth factor binding protein-1 expression in human endometrial stromal cells. Gynecol Endocrinol 2015 Apr 9: 1-5 PMID: PMC25856298.
Kayisli UA, Basar M, Guzeloglu-Kayisli O, Semerci N, Atkinson HC, Shapiro J, Summerfield T, Huang SJ, Prelle K, Schatz F, Lockwood CJ. Long-acting progestin-only contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell survival. Proc Natl Acad Sci USA, 2015 Apr 6, pii: 201424814 [Epub ahead of print], PMCID: PMC4413279.
Piao L, Chen CP, Yeh CC, Basar, M, Masch R, Cheng YC, Lockwood CJ, Schatz F, Huang S. Chinese herbal medicine for miscarriage affect decidual micro-environment and fetal growth. Placenta 2015 Feb 24; pii: S0143-4004(15)00273-8, doi: 10,1016, PL-14-20082R2. PMCID: PMC4395550.
Shapiro JP, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Huang SJ, Suarez AA, Ozer HG, Schatz F, Lockwood CJ. Mass spectrometry identification of potential mediators of progestin-only contraceptive-induced abnormal uterine bleeding in human endometrial stromal cells. Contraception. 2015, 91: 253-260 PMCID: PMC4395468.
Sutherland S, Farrell RM, Lockwood C. Genetic screening and testing in an episode-based payment model: preserving patient autonomy. Obstet Gynecol. 2014 Nov; 124(5):987-91 PMID: PMC25437728.
Radunovic N, Lockwood CJ, Stanojlovic O, Steric M, Kontic-Vucinic O, Sulovic N, Hrncic D, Ackerman IV WE. Fetal and maternal plasma homocysteine levels during the second half of uncomplicated pregnancy. J Matern Fetal Neonatal Med. 2014 Aug 27:1-6. [Epub ahead of print] PMID: PMC25162468.
Lockwood CJ, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Murk W, Wang J, De Paz N, Shapiro JP, Masch RJ, Semerci N, Huang SJ, Schatz F. Interferon-γ protects first-trimester decidual cells against aberrant matrix metalloproteinases 1, 3, and 9 expression in preeclampsia. Am J Pathol. 2014 Sep;184(9):2549-59 PMCID:
PMC4188280.
Guzeloglu-Kayisli O, Basar M, Shapiro JP, Semerci N, Huang JS, Schatz F, Lockwood CJ, Kayisli UA.
Pettker CM, Thung SF, Lipkind HS, Illuzzi JL, Buhimschi CS, Raab CA, Copel JA, Lockwood CJ, Funai EF.
Faramarzi S, Kayisli UA, Kayisli O, Basar M, Shapiro J, Semerci N, Juang J, Piao L, Schatz F, Lockwood CJ. Decidual cell expressed tissue factor promotes endometrial hemostasis while mediating abruption associated preterm birth. Advances in Reproductive Sciences Vol 1, No 3; November 1, 2013 DOI: 10.4236/arsci2013.13007.
Lockwood CJ, Huang SJ, Chen CP, Huang Y, Xu J, Faramarzi S, Kayisli O, Kayisli UA, Koopman L, Smedts D, Buchwalder LF, Schatz F. Decidual cell regulation of natural killer cell-recruiting chemokines: Implications for the pathogeneisis and prediction of pre-eclampsia. Am J Path. 2013 Sep; 183(3):841-56. doi: 10.1016/j.ajpath.2013.05.029. PMCID: PMC3763772
Falah N, McElroy J, J Snegovskikh V, Lockwood, CJ, Norwitz E, Murray JC, Kuczynski E, Menon R, Teramo K, Muglia LJ, Morgan T. Investigation of genetic risk factors for chronic adult diseases for association with preterm birth. Hum Genet. 2013 Jan;132(1):57-67. PMCID: PMC3864772.
Lockwood CJ, Kayisli, UA, Stocco C, Murk W, Vatandaslar E, Buchwalder LF, Schatz F. Abruption-induced preterm delivery is associated with thrombin-mediated functional progesterone withdrawal in cecidual cells. Am J Pathol. 2012; 181(6): 2138-48. [Epub 2012 Oct 9]. PMCID: PMC3509762.
Krikun, G, Trezza J, Shaw J, Rahman M, Guller S, Abrahams VM, Lockwood, CJ. LipopolysaccharideAppears to Activate Human Endometrial Endothelial Cells Through TLR-4 Dependent and TLR-4-Independent Mechanisms. Am J of Reprod Immunol. 2012 Sep;68(3):233-7. PMCID: PMC3418410.
Erekson EA, Brousseau EC, Dick MA, Ciarleglio MM, Lockwood CJ, Pettker CM. Maternal postoperative complications after nonobstetric antenatal surgery. J Matern Fetal Neonatal Med. 2012 Dec; 25(12):2639-44. PMCID: PMC3687346.
Yonkers, KA, Norwitz ER, Smith MV, Lockwood CJ, Luchansky E, Lin H, Belanger K. Depression and serotonin reuptake inhibitor treatment as risk factors for preterm birth. Epidemiology. 2012 Sep;23(5):677-685. PMCID: PMC3415566.
Schatz F, Kayisli UA, Vatandaslar E, Ocak N, Guller S, Abrahams VM, Krikun G, Lockwood CJ. Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy. Am J Reprod Immunol. 2012 Aug;68(2):146-53. PMCID: PMC3395732.
Yang H, Zhou Y, Edelshain B, Schatz F, Lockwood CJ, Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction. 2012 Apr;143(4):531-8. PMID: PMC22279148.
Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. Reprod Sci. Jun;19(6):572-9. PMCID: PMC3439122.
Krikun G, Booth CJ, Buchwalder L, Schatz F, Osol G, Mandala M, Lockwood CJ. Effects of etonogestrel Treatment in the reproductive organs and uterine arteries of nonoophorectomized guinea pigs. Reprod Sci. 2012; 12(4):400-6. [Epub 2012 Jan 19.] PMCID: PMC3343066.
Leung AN, Bull TM, Jaeschke R, Lockwood CJ, Boiselle PM, Hurwitz LM, James AH, McCullough LB, Menda Y, Paidas MJ, Royal HD, Tapson VF, Winer-Muram HT, Chervenak FA, Cody DD, McNitt-Gray MF, Stave CD, Tuttle BD; ATS/STR Committee on Pulmonary Embolism in Pregnancy. American Thoracic Society documentations: an official American Thoracic Society/Society of Thoracic Radiology Clinical Practice Guideline-Evaluation of Suspected Pulmonary Embolism in Pregnancy. Radiology. 2012 Feb; 262(2):635-46. PMID: PMC22282185.
Cakmak H, BAsar M, Seval-Celik, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis. Reprod Sci 2012; 19(6):572-9. [Epub ahead of print Jan 19] PMCID: PMC3439122.
Krikun G, Trezza J, Shaw J, Rahman M, Guller S, Abrahams VM, Lockwood CJ. Lipopolysaccharide appears to activate human endometrial endothelial cells through TLR-4-dependent and TLR-4-independent mechanisms. Am J Reprod Immunol 2012; 68(3):233-7. Epub 2012 Jun 4. PMCID: PMC3418410.
Wu ZM, Yang H, Li M, Yeh CC, Schatz F, Lockwood CJ, Di W, Huang SJ. Pro-inflammatory cytokine-stimulated first trimester decidual cells enhance macrophage-induced apoptosis of extravillous trophoblasts. Placenta. 2012 Mar;33(3):188-94. Epub 2011 Dec 31. PMCID: PMC3406179.
Leung AN, Bull TM, Jaeschke R, Lockwood CJ, Boiselle PM, Hurwitz LM, James AH, McCullough LB, Menda Y, Paidas MJ, Royal HD, Tapson VF, Winer-Muram HT, Chervenak FA, Cody DD, McNitt-Gray MF, Stave CD, Tuttle BD; ATS/STR Committee on Pulmonary Embolism in Pregnancy. An official American Thoracic Society/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy. Am J Respir Crit Care Med. 2011 Nov 15;184(10):1200-8. PMID: PMC22086989.
Rosenberg VA, Buhimschi IA, Lockwood CJ, Paidas MJ, Dulay AT, Ramma W, Abdel-Razeq SS, Zhao G, Ahmad S, Ahmed A, Buhimschi CS. Heparin elevates circulating soluble fms-like tyrosine kinase-1 immunoreactivity in pregnant women receiving anticoagulation therapy. Circulation. 2011 Dec 6;124(23): 2543-53. PMCID: PMC22082677.
Han CS, Mulla MJ, Brosens JJ, Chamley LW, Paidas MJ, Lockwood CJ, Abrahams VM. Aspirin and heparin effect on basal and antiphospholipid antibody modulation of trophoblast function. Obstet Gynecol. 2011 Nov;118(5):1021-8. PMCID: PMC3199133.
Lockwood CJ. Mechanisms of normal and abnormal endometrial bleeding. Menopause. 2011 Apr;18(4):408-11. PMCID: PMC3074585.
Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ. Novel therapies targeting endometriosis. Reprod Sci 2011 Sept;18(9):814-23 PMCID: PMC4046304.
Han CS, Schatz F, Lockwood CJ. Abruption-associated prematurity. Clin Perinatol 2011 Sep;38(3):402-21. PMCID: PMC3175371.
Yonkers KA, Gotman N, Smith MV, Forray A, Belanger K, Brunetto WL, Lin H, Burkman RT, Zelop CM, Lockwood CJ. Does antidepressant use attenuate the risk of a major depressive episode in pregnancy? Epidemiology. 2011 Nov;22(6):848-54. doi: 10.1097/EDE.0b013e3182306847 [Epub ahead of print] PMCID: PMC3188383.
Cocco E, Varughese J, Buza N, Bellone S, Lin KY, Bellone M, Todeschini P, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Carrara L, Tassi R, Pecorelli S, Lockwood CJ, Santin AD. Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor. Clin Exp Metastasis. 2011 Oct;28(7):689-700. PMCID: PMC3697933.
Cocco E, Varughese J, Buza N, Bellone S, Glasgow M, Bellone M, Todeschini P, Carrara L, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Lockwood CJ, Santin AD. Expression of tissue factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor. BMC Cancer. 2011 Jun 22;11:263. doi: 10.1186/1471-2407-11-263 PMCID: PMC3141777.
Pettker CM, Thung SF, Raab CA, Donohue KP, Copel JA, Lockwood CJ, Funai EF. A comprehensive obstetrics patient safety program improves safety climate and culture. Am J Obstet Gynecol 2011;204:216.e 1-6. PMID: PMC21376160.
Kumar D, Schatz F, Moore RM, Mercer BM, Rangaswamy N, Mansour JM, Lockwood CJ, Moore JJ. The effects of Thrombin and Cytokines upon the Biomechanics and Remodeling of Isolated Amnion Membrane, In Vitro. Placenta. 2011; 32(3):206-13. PMCID: PMC3049450.
Lockwood CJ, Huang SJ, Krikun G, Caze R, Rahman M, Buchwalder LF, Schatz F. Decidual hemostasis, inflammation, and angiogenesis in pre-eclampsia. Semin Thromb Hemost 2011; 37:158-164. PMCID: PMC3847903.
Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, et al. Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: Potential role of fibroblast monocyte chemotactic protein-1. Am J Reprod Immunol. 2010; 65(5): 470-0. PMCID: PMC3071455.
Buhimschi CS, Schatz F, Krikun G, Buhimschi IA, Lockwood CJ. Novel insights into molecular mechanisms of abruption-induced preterm birth. Expert Rev Mol Med. 2010;12:e35. PMCID: PMC4792258.
Lockwood CJ, Murk WK, Kayisli UA, Buchwalder LF, Huang SJ, Arcuri F, Li M, Gopinath A, Schatz F.Regulation of interleukin-6 expression in human decidual cells and its potential role in chorioamnionitis. Am J Pathol. 2010; 177:1755-64. Epub 2010 Aug 19. PMCID: PMC2947272.
Moore RM, Schatz F, Kumar D, Mercer BM, Abdelrahim A, Rangaswamy N, Bartel C, Mansour JM, Lockwood CJ, Moore JJ. Alpha-lipoic acid inhibits thrombin-induced fetal membrane weakening in vitro. Placenta. 2010 ;31:886-92. Epub 2010 Aug 14. PMCID: PMC2945435.
Cocco E, Hu Z, Richter CE, Bellone S, Casagrande F, Bellone M, Todeschini P, Krikun G, Silasi DA, Azodi M Schwartz PE, Rutherford TJ, Buza N, Pecorelli S, Lockwood CJ, Santin AD. hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma. Br J Cancer. 2010;103:812-9. Epub 2010 Aug 10. PMCID: PMC2966612.
Basar M, Yen CF, Buchwalder LF, Murk W, Huang SJ, Godlewski K, Kocamaz E, Arda O, Schatz F, Lockwood CJ, Kayisli UA. Preeclampsia-related increase of interleukin-11 expression in human decidual cells. Reproduction. 2010;140:605-12. Epub 2010 Jul 28. PMCID: PMC3795512.
Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Arcuri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ. The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia. Am J Pathol. 2010;177(5):2472-82. Epub 2010 Sep 9. PMCID: PMC2966804.
Lykke JA, Langhoff-Roos J, Lockwood CJ et al. Mortality of mothers from cardiovascular and non-cardiovas-cular causes following pregnancy complications in first delivery. Paediatr Perinat Epidemiol. 2010; 24:323-30. PMID: PMC20618721.
Lockwood CJ, Stocco C, Murk W, Kayisli UA, Funai EF, Schatz F. Human labor is associated with reduced decidual cell expression of progesterone, but not glucocorticoid, receptors. J Clin Endocrinol Metab. 2010; 95:2271-5. PMCID: PMC2869548.
Krikun G, Hu Z, Osteen K, Bruner-Tran KL, Schatz F, Taylor HS, Toti P, Arcuri F, Konigsberg W, Garen A, Booth CJ, Lockwood CJ. The immunoconjugate "Icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis. Am J Pathol. 2010; 176:1050-6. Epub 2009 Dec 30. PMCID: PMC2808107.
Krikun G, Buhimschi IA, Hickey M, Schatz F, Buchwalder L, Lockwood CJ. Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans. J Angiogenes Res. 2010; 2:8. PMCID: PMC2874514.
Sarno J, Schatz F, Huang SJ, Lockwood C, Taylor HS. Thrombin and interleukin-1beta decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss. Mol Hum Reprod. 2009; 15:451-7. Epub 2009 Apr 22. PMCID: PMC2722817.
Lockwood CJ, Paidas M, Murk WK, Kayisli UA, Gopinath A, Huang SJ, Krikun G, Schatz F. Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption. Thromb Res. 2009; 124(5): 516-20. Epub 2009 Aug 31. PMCID: PMC2787516.
Krikun G, Lockwood CJ, Paidas MJ. Tissue factor and the endometrium: from physiology to pathology. Thromb Res. 2009; 124:393-6. Epub 2009 Jul 19. PMID: PMC19619892.
Snegovskikh VV, Schatz F, Arcuri F, Toti P, Kayisli UA, Murk W, Guoyang Luo, Lockwood CJ, Norwitz ER. Intra-amniotic infection upregulates decidual cell vascular endothelial growth factor (VEGF) and neuropilin-1 and-2 expression: implications for infection-related preterm birth. Reprod Sci. 2009; 16:767-80. Epub 2009 May 27. PMID: PMC19474288.
Lockwood CJ, Nadel AS, King ME, Roberts DJ. Case records of the Massachusetts General Hospital. Case 16-2009. A 32-year-old pregnant woman with an abnormal fetal ultrasound study. N Engl J Med. 2009; 360: 2225-35. PMID: PMC19458368.
Lockwood CJ, Murk W, Kayisli U, Buchwalder LF, Huang ST, Funai EF, Krikun G, Schatz F. Progestin and thrombin regulate tissue factor expression in human term decidual cells. J Clin Endocrinol Metab. 2009; 94: 2164-70. PMCID: PMC2690421.
Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF 3rd, Petraglia F. Inflammation and pregnancy. Reprod Sci. 2009, 16:206-15. PMID: PMC19208789.
Lockwood CJ, Krikun G, et al. Decidualized human endometrial stromal cells mediate hemostasis, angiogenesis, and abnormal uterine bleeding. Reprod Sci 2009; 16: 162-170. PMCID: PMC3070956
Pettker CM, Thung SF, Norwitz ER, Buhimschi CS, Raab CA, Copel JA, Kuczynski E, Lockwood CJ, Funai EF. Impact of a comprehensive patient safety strategy on obstetric adverse events. Am J Obstet Gynecol 2009; 200(5):492.e1-8. PMID: PMC19249729.
Chedraui P, Lockwood CJ, Schatz et al. Increased plasma soluble fms-like tyrosine kinase 1 (sFlt-1) and endoglin levels in pregnancies complicated with preeclampsia. J Materal-Fetal & Neonatal Medicine 2009; 6:1-6. PMID: PMC19350449.
Arcuri F, Toti P, Buchwalder L, Casciaro A, Cintorino M, Schatz F, Rybalov B, Lockwood CJ. Mechanisms of leukocyte accumulation and activation in chorioamnionitis: Interleukin 1Beta and tumor necrosis factorAlpha enhance colony stimulating Factor 2 expression in term decidua. Reprod Sci. 2009; 16:453-61. PMCID: PMC3046766.
N Hossain, T Shamsi, E Kuczynski, CJ Lockwood, MJ Paidas. Liver dysfunction in pregnancy: an important cause of maternal and perinatal morbidity and mortality in Pakistan. Obstetric Medicine 2009; 2:17-20.
Paidas MJ, Ku DH, Urban G, Hossain N, Rebarber A, Lockwood CJ, Arkel YS. Elevated first trimester solublefibrin polymer is associated with adverse pregnancy outcome in thrombophilic patients. Blood Coagul Fibrinolysis. 2008; 19:824-6. PMCID: PMC3036561.
Guller S, Buhimschi CS, Ma YY, Huang ST, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Lab Invest. 2008; 88:1057-67. PMCID: PMC2682720.
Cackovic M, Buhimschi CS, Zhao G, Funai EF, Norwitz ER, Kuczynski E, Lockwood CJ, Buhimschi IA.Fractional excretion of tumor necrosis factor-alpha in women with severe preeclampsia. Obstet Gynecol. 2008; 112:93-100. PMCID: PMC2670937.
Lockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, Buhimschi C, Huang SJ, Krikun G, Schatz F. Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells. Am J Pathol. 2008; 172:1571-9. PMCID: PMC2408417.
Krikun G, Schatz F, Taylor H, Lockwood CJ. Endometriosis and tissue factor. Ann NY Acad Sci. 2008;1127:101-5. PMCID: PMC3129033.
Lockwood CJ, Krikun G, Caze R, Rahman M, Buchwalder LF, Schatz F. Decidual Cell-expressed TissueFactor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia-related Angiogenesis. Ann NY Acad Sci. 2008; 1127:67-72.
Luo G, Bahtiyar MO, Snegovskikh VV, Schatz F et al. Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth. Reprod Sci. 2008;15:147-55.
Lockwood CJ, Oner C, Uz YH, Kayisli UA, Huang ST. Matrix Metalloproteinase 9 (MMP9) Expression in
Huang S, Chen CP, Schatz F, Rahman M, Abrahams V, Lockwood C. Pre-eclampsia is associated with Dendritic cell recruitment into the uterine decidua. J Pathol. 2008; 214:328-36.
Oner C, Schatz F, Kizilay G, Murk WK, Buchwalder LF, Kayisli U, Arici A, Lockwood CJ. Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells:implications for treatment of chorioamnionitis-induced preterm delivery. J Clin Endocrinol Metab. 2008; 93:252-9. PMCID: PMC2190749
Hossain N, Shamsi T, Haider S, Soomro N, Khan NH, Memon GU, Farzana T, Ansari S, Triche EW, Kuczynski E, Lockwood CJ, Paidas MJ. Use of recombinant activated factor VII for massive postpartum hemorrhage. Acta Obstet Gynecol Scand. 2007; Volume 86.3 1-7
Vigano P, Cintorino M, Schatz F, Lockwood CJ, Arcuri F. The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface. Semin Immunopathol. 2007; 29:135-50.
Martin R, Taylor MB, Krikun G, Lockwood C, et al. Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein 1 Response Elements. J Clin Endocrinol Metab 2007; 92:1920-26.

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Prevention Of Preterm Birth (PTB) By Inhibition Of FKBP51

The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.Pharmaceuticals