JOSHUA HUTCHESON

Bakhshian Nik A, Hutcheson JD, Aikawa E, “Extracellular Vesicles As Mediators of Cardiovascular Calcification”, Frontiers in Cardiovascular Medicine. 2017 Dec 11;4:78.

C Goettsch, H Iwata, JD Hutcheson, CJ O’Donnell, R Chapurlat, NR Cook, M Aikawa, P Szulc, E Aikawa, “Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men”, Arteriosclerosis, Thrombosis, and Vascular Biology, 37(5): 1005-1011, 2017.

JD Hutcheson, MC Blaser, E Aikawa, “Giving Calcification Its Due: Recognition of a Diverse Disease A First Attempt to Standardize the Field”, Circulation Research, 120(2):270-273, 2017.

K Yabusaki, JD Hutcheson, P Vyas, S Bertazzo, SC Body, M Aikawa, E Aikawa, “Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development”, Frontiers in Cardiovascular Medicine, Nov 4; 3:44, 2017.

Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E, “Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress”, Circulation Research, 121(3): 220-233, 2017.

R Krammann, C Goettsch, J Wongboonsin, H Iwata, RK Schneider, C Kuppe, N Kaesler, M Chang-Panesso, F Machado, S Gratwohl, C Vemuri, K Madhurima, JD Hutcheson, S Jain, E Aikawa, BD Humpreys, “Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease”, Cell Stem Cell, 19(5):628-642, 2016. Link to Publication

C Goettsch*, JD Hutcheson*, S Hagita*, M Rogers, MD Creager, T Pham, J Choi, AK Mlynarchik, MF Kjolby, M Aikawa, E Aikawa, “A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification”, Atherosclerosis, 251:109-18, 2016. *Equal Contribution Link to Publication

C O’Rourke, G Shelton, JD Hutcheson, MF Burke, T Martyn, HR Shakartzi, MD Buswell, RE Tainsh, B Yu, DK Rhee, C Wu, M Derwall, ES Buys, PB Yu, KD Bloch, E Aikawa, DB Bloch, R Malhotra, “Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation”, Journal of Visualized Experiments, May 31;(111), 2016.

JD West, EJ Carrier, NC Bloodworth, AK Schroer, P Chen, LM Ryzhova, S Gladson, S Shay, JD Hutcheson, WD Merryman, “Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension”, PLoS One, 11(2):e0148657, 2016.

J Krohn, JD Hutcheson*, E Martinez-Martinez, WS Irvin, S Bertazzo, CVC Bouten, MP Bendeck, E Aikawa*, “Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via TGF-β Signaling”, Arteriosclerosis, Thrombosis, and Vascular Biology, 36(3):525-33, 2016. *Co-corresponding authors Link to Publication

JL Ruiz, Weinbaum S, Aikawa, E, JD Hutcheson, “Zooming in on the genesis of atherosclerotic plaque microcalcifications”, Journal of Physiology, 594(11):2915-27, 2016.

JD Hutcheson, C Goettsch, S Bertazzo, N Maldonado, JL Ruiz, W Goh, K Yabusaki, T Faits, C Bouten, P Libby,  M Aikawa, S Weinbaum, E Aikawa, “High-resolution microscopic visualization of vascular calcification genesis, growth, and association with collagen in atherosclerotic plaques”, Nature Materials, 15(3):335-43, 2016.

C Goettsch, JD Hutcheson,  M Aikawa, A Nykjaer, M Kjolby, M Rogers, T Michel, M Shibasaki, DJ Rader, P Libby, SA Singh, E Aikawa, “Sortilin mediates vascular calcification via its recruitment into extracellular vesicles”, Journal of Clinical Investigation, 126(4):1323-36, 2016. Link to Publication

J Hjortnaes, C Goettsch, JD Hutcheson, G Camci-Unal, L Lax, K Scherer, FJ Schoen, J Kluin, A Khademhosseini, E Aikawa, “Simulating Early Calcific Aortic Valve Disease within a 3D Heart Valve-like Construct: A Role for Myofibroblast Differentiation”, Journal of Molecular and Cellular Cardiology, 94:13-20, 2016.

JD Hutcheson, C Goettsch, MA Rogers, E Aikawa, “Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach”, Invited Review, Seminars in Cell and Developmental Biology, 46:68-77, 2015. Link to Publication

J Hjortnaes, K Shapero, C Goettsch, JD Hutcheson, J Keegan, J Kluin, JE Mayer, J Bischoff, E Aikawa, “Valvular Interstitial Cells Suppress Calcification of Valvular Endothelial Cells”, Atherosclerosis, 242(1): 251-260, 2015. Link to Publication

J Ruiz, JD Hutcheson, E Aikawa, “Cardiovascular Calcification: Current Controversies and Novel Concepts”, Invited Review, Cardiovascular Pathology, 10(7), 2015. Link to Publication

JD Hutcheson, C Goettsch, T Pham, M Aikawa, SA Singh, E Aikawa, “Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol”, Journal of Extracellular Vesicles, Dec 5;3:25129, 2014. Link to Publication

JD Hutcheson, N Maldonado, E Aikawa, “Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability”, Current Opinion in Lipidology, 25(5):327-32, 2014. Link to Publication

JD Hutcheson, E Aikawa, WD Merryman, “Potential drug targets for calcific aortic valve disease”, Nature Reviews Cardiology, 11(4): 218-31, 2014. Link to Publication

C Goettsch, JD Hutcheson, and E Aikawa, “MicroRNA in cardiovascular calcification: Focus on targets and extracellular vesicle delivery mechanisms”, Circulation Research, 112(7): 1073-84, 2013. Link to Publication

JD Hutcheson, J Chen, MK Sewell-Loftin, LM Ryzhova, CI Fisher, YR Su, WD Merryman, “Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts”, Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33(1): 114-20, 2013. Link to Publication

JD Hutcheson, L Ryzhova, V Setola, and WD Merryman, “5-HT2B antagonism arrests non-canonical TGF-β1-induced myofibroblast differentiation”, Journal of  Molecular and Cellular Cardiology, 53(5): 707-714, 2012.

JD Hutcheson, R Venkataraman, FJ Baudenbacher, and WD Merryman, “Intracellular Ca2+ accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts”, Journal of Biomechanics, 45(5): 888-894, 2012. Link to Publication

JD Hutcheson, V Setola, BL Roth, and WD Merryman, “Serotonin Receptors and Heart Valve Disease—It Was Meant 2B”, Phamacology & Therapeutics, 132(2): 146-157, 2011. Link to Publication