Expert Profile

Christopher Solis

Asst Professor

HEALTH, NUTRITION, & FOOD SCIENCES | COLLEGE OF HEALTH & HUMAN SCIENCES

Research Terms & Keywords

Research Terms

Biotechnology Genetic Engineering Protein Engineering Artificial Intelligence Biochemistry Cell Biology Gravitational Biology Molecular Biology Structural Biology Physiology Cellular Physiology Cardiology Cardiovascular Diseases and Disorders Heart Diseases Cardiomyopathies Atrophic Disorders

Keywords

Biochemistry Bioengineering Biophysics Cardiac Cardiomyopathy Cardiovascular Disease Computational Biophysics Fibrosis Hypertrophic Cardiomyopathy Molecular Biophysics Molecular Physiology Muscle Atrophy Skeletal Muscle Tissue Biomechanics Tissue Culture Tissue Engineering

Industries

Modeling, Simulation, & Training (MST) Biotech Health Care

Research Projects

Ends

Title

08-2026

Post-translational mechanisms of cardiac adaptation during unloading Post-translational mechanisms of cardiac adaptation during unloading

Awards & Honors

Post-translational mechanisms of cardiac adaptation during unloading R00HL151825

National Heart Lung Blood InstituteNHLNational Institutes of Health-NHLBNational Institutes of Health, National Heart, Lung, and Blood Institute ▪ 2023

Publications

Munoz, M, Solis, C, McCann, M, Park, J, Rafael-Clyke, K, Chowdhury, SAK, Jiang, Y, Rosas, PC (2024) P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function. Molecular and cellular biochemistry, 10.1007/s11010-024-04968-4. Advance online publication. https://doi.org/10.1007/s11010-024-04968-4
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Soli?s C, Hasnain Y, Novikova A, Endress JE, Gonza?lez-Sa?nchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy. bioRxiv [Preprint]. 2023: 2023.07.26.550731. doi: 10.1101/2023.07.26.550731
Woitowich, NC., Hengel, SR., Solis, C, Vilgalys, TP, Babdor, J, Tyrrell, DJ (2024). Analysis of NIH K99/R00 awards and the career progression of awardees. eLife, 12, RP88984. https://doi.org/10.7554/eLife.88984. Highlighted on the cover of the issue.
Soli?s C*, Warren CM, Dittloff K, DiNello E, Solaro RJ, Russell B. Cardiomyocyte external mechanical unloading activates modifications of ?-actinin differently from sarcomere-originated unloading. FEBS J. 2023. doi: 10.1111/febs.16925. Highlighted on the cover of the issue
Soli?s C, Thompson WC, Pen?a JR, McDermott-Roe C, Langa P, Warren CM, Chrzanowska M, Wolska BM, Solaro RJ, Pieter Detombe and Goldspink PH (2022) Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes. Front. Physiol. 13:1028345. doi: 10.3389/fphys.2022.1028345
Chaves G, Rodri?guez-Corrales JA, Soli?s, C*. Editorial for ‘Issue focus on 2nd Costa Rica biophysics symposium — March 11th–12th, 2021’. Biophys Rev. 2022 14(2), 545-548. https://doi.org/10.1007/s12551-022-00947-5
Dittloff KT, Spanghero E, Soli?s C, Banach K, Russell B. Transthyretin deposition alters cardiomyocyte sarcomeric architecture, calcium transients and contractile force. Physiological Reports. 2022 10 (5), e15207
Soli?s C, Russell B. Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification. Biophys Rev. 2021 13(5), 679-695. doi:10.1007/s12551- 021-00835-4
Soli?s C*, Chaves G, & Rodriguez-Corrales, J. Announcing the call for the Issue Focus on the 2nd Costa Rican Biophysics Symposium-virtual meeting. Biophys Rev. 2021; 1-2. doi:10.1007/s12551- 021-00816-7
Soli?s C, Solaro RJ. Novel insights into sarcomere regulatory systems control of cardiac thin filament activation. J Gen Physiol. 2021 Jul 5;153(7):e202012777. doi: 10.1085/jgp.202012777. PMID: 33740037
Russell B, Soli?s C. Mechanosignaling pathways alter muscle structure and function by post- translational modification of existing sarcomeric proteins to optimize energy usage. J Muscle Res Cell Motil. 2021 Feb 17. doi: 10.1007/s10974-021-09596-9. PMID: 33595762.
Johnson D, Landim-Vieira M, Soli?s C, Zhu L, Robinson JM, Pinto JR, Chalovich JM. Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems. Biochemistry. 2020 Sep 22; 59(37):3487-3497. doi: 10.1021/acs.biochem.0c00430. Epub 2020 Sep 9. PMID: 32840354.
Soli?s C*, Robinson JM. Cardiac troponin and tropomyosin bind to F-actin cooperatively, as revealed by fluorescence microscopy. FEBS Open Bio. 2020;10(7):1362-1372. doi:10.1002/2211- 5463.12876
Soli?s C*, Rodri?guez-Corrales JA, Alvarado FJ Lessons Learned from Organizing a Biophysics Symposium in a Developing Country. The Biophysicist. 2020; 1(2): 2. doi: https://doi.org/10.35459/tbp.2019.000144
Soli?s C, Russell B. CapZ integrates several signaling pathways in response to mechanical stiffness. J Gen Physiol. 2019; 151(5):660-669. doi:10.1085/jgp.201812199. Highlighted on the cover of the issue
Mkrtschjan MA, Soli?s, C, Wondmagengn, A, Majithia, J, Russell, B. PKC epsilon signaling effect on actin assembly is diminished in cardiomyocytes when challenged to additional work in a stiff microenvironment. Cytoskeleton. 2018; 75(8): 363-371
Mkrtschjan M.A., Gaikwad, S.B., Kappenman, K.J., Soli?s, C., Dommaraju, S., Le, L., Desai, TA, Russell, B. Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography. J Cell Physiol. 2018; 233(4): 3672-3683
Le, LV, Mohindra, P, Fang, Q, Sievers, RE, Mkrtschjan M, Solis, C., Safraneke, CW, Russell, B, Lee, RJ, Desai, TA. Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction. Biomaterials. 2018; 169: 11-21.doi: 10.1016/j.biomaterials.2018.03.042. PMID: 29631164; PMCID: PMC5931400.
Soli?s, C*, Kim, GH, Moutsoglou, ME, Robinson, JM. Ca2+ and Myosin Cycle States Work as Allosteric Effectors of Troponin Activation. Biophysical Journal. 2018; 115: 1762–1769
Rodri?guez-Corrales, J.A., Gonza?lez Murillo, A.H., Mora Aparicio, C., Solis-Ocampo, C. Control Banding for wastes: a spreadsheet for a simple and fast comparison of impact on the environment of wastes with chemical substances. Uniciencia. 2013; 27(1): 140-155. 2013. ISSN 1101 – 0275