Abstract
Obtaining large-scale
electrophysiological recordings of brain activity in behaving animals is
challenging. Intracranial electrode probes are often implanted into various
regions of the animal’s brain for that purpose. Stereotactic devices can be
used to accurately guide and place such intra-body devices in the brain. The
current methods of placing the intracranial devices require head restraints and
the animal’s head to be leveled at all times. These devices can interfere with the
normal activities of the animal as they are often left on the animal for long-term
treatments. FIU scientists
have created a customizable NeuroHat stereotactic device that can attach
directly to an animal’s skull and protect intracranial implants without
interfering with the animal’s normal activities. The NeuroHat can include a
drill guide for accurately placing burr holes and implant shuttles. We are looking for
business investors to further develop and commercialize NeuroHat System for large
animals as a potentially viable economical alternative to implement in the most
common surgical approach in preclinical studies with large animals.Benefit
Minimally invasive and causes less damage to the animal and requires fewer adjustment of the head during surgery Saves time and minimizes errors in the procedure Customizable to use for different species Eliminates the need for costly micromanipulator systems used with large animal stereotaxic devicesMarket Application
The device has applications in basic and preclinical large animal brain research for brain stimulation, the delivery of drugs, and electrophysiological recording in freely behaving animals
