Abstract
Near infrared ray (NIR) based
technology is emerging as an important tool for studying different aspects of
biological systems as it offers several advantages over the ultraviolet and
visible spectral range, such as minimum absorption and scattering, and deeper
in vivo penetration. Further, when applied in conjunction with nanoparticles,
NIR irradiation can be employed for treating in vivo models of cancer or other
diseases. Unfortunately, due to the difficulty in minimizing or avoiding
damaging thermal effects on the brain cells, this combined technique has
largely been restricted to models of peripheral cancer therapy. In addition,
several instruments are required for simultaneously applying a photonic
irradiation source and optically evaluating its thermal effects on brain cells
and/or other tissues.FIU inventors have developed a
NIR exposure system for conducting photonic and optical treatments on
biological samples with additional functions including temperature monitoring
and real-time microscopic imaging. The system can also be combined with
nanoparticles (NPs) treatment to accomplish non-invasive, on-demand drug
targeting, brain cell specific gene delivery, and magnetized
photo-biomodulation for treating various CNS or peripheral disorder models.
Benefit
Offers a single platform for simultaneous NIR phototargeting, and temperature and cell morphology measurements Provides a non-invasive tool for biological studies combining NPs and NIR
Market Application
Photonic and optical treatments of in-vitro brain cell cultures, in-vivo CNS and peripheral nervous system (PNS) tissue samples, as well as other body tissues Non-invasive, on-demand drug targeting, brain cell specific gene delivery, and magnetized photo-biomodulation for treating various CNS disorder models
Brochure
