Abstract
Detection of ultra-trace level of
contaminants in complex food, biological and/or environmental samples is often
necessary for health and safety reasons. Unfortunately, such detection is often
difficult, due to a variety of reasons, including the complexity of the samples
that are being tested, and the presence of numerous potential interferents in
these samples. MIPs are synthetic polymeric materials that possess specific
cavities complimentary to the shape, size, and functional groups of a template molecule
used in the imprinting process. Currently, several techniques exist for the
synthesis of MIPs; however, they suffer from several drawbacks such as
non-specific adsorption, low adsorption capacity, low imprinting factor, low
sample throughput, and irreversible analyte loss leading to ineffective removal
of the template and poor data quality.FIU inventors have developed
chemical compositions and synthesis strategies to create MIPs via sol-gel processes
using organic, inorganic, or metallic target analyte. The resulting MIPs are
hybrid organic-inorganic or inorganic three-dimensional network exhibiting high
affinity towards a target analyte and its structural analogs and remain
indifferent to other molecules or species present in the same sample matrix.
Benefit
Offers an effective strategy to create MIPs having high affinity towards the analyte(s) of interest, similar to antibody-antigen interactions Provides substrates with adjustable porosity, tunable selectivity, high thermal stability, solvent stability, and stability over a wide range of pH
Market Application
Detection and extraction of small amounts of substances in food, biological and environmental samples Controlled release drug delivery
Publications
Kechagia M, Samanidou V, Kabir A,
Furton KG. One-pot synthesis of a multi-template molecularly imprinted polymer
for the extraction of six sulfonamide residues from milk before
high-performance liquid chromatography with diode array detection. J Sep Sci.
2018;41(3):723-731. doi:10.1002/jssc.201701205
Brochure
