Abstract
Supports for reversed phase high-performance liquid
chromatography (RP-HPLC) column, normal phase high-performance liquid
chromatography (NP-HPLC) column, and hydrophilic interaction liquid
chromatography (HILIC) column are silica particles coated with organic ligands
via silane chemistry. As a result, only a very small portion of the stationary
phase contributes to retention and selectivity. The currently used bonded
phases for these chromatography columns suffer from a number of shortcomings:
silica particles limit the loading of organic ligands, which leaves many
surface silanol groups unattended on the silica surface, and results in
chemical instability, particularly when using basic solvents. FIU inventors have developed sol-gel sorbent or
chromatography stationary phase comprising particles of a metal oxide gel
containing polymeric segments uniformly distributed throughout the metal oxide
gel. The chemical incorporation of various organic polymers into the sol-gel
hybrid inorganic-organic matrix opens up the possibility of creating hundreds
of novel sorbents with unique selectivity.
Benefit
Eliminates the need of using silica substrate to hold different polar functional moietiesDisplays high resistance against high temperature, harsh chemical environment, with pH stability that can range from 1-13Provides a high surface area for rapid interaction with the analyte(s).Eliminates the need of solvent evaporation and sample reconstitution when used as SPE sorbents
Market Application
Food, pharmaceutical, environmental, toxicological, clinical, and forensic analysisEnvironmental remediation and antimicrobial and/or other protective coatings in food or pharmaceutical packaging
Brochure
