Abstract
Dynamic Fabric Phase Sorptive Extraction (DFPSE) disks are capable of extracting target analyte(s)
exhaustively from unmodified sample matrices containing high volume of matrix
interferents including particles, debris, biomass, cells, tissues, proteins
without employing any sample clean-up exercise.The technology
provides the process of making DFPSE disks by chemically immobilizing organic
polymers or ligands on a flexible substrate resulting in an exhaustive sample
preparation (cleaning/preconcentration) to accomplish high recovery of target
analyte(s) in a short period of time.DFPSE provides
flexible, open, flat and easily accessible surface for rapid sorbent-analyte
interaction. Since both the surfaces and inner matrix of the substrate are
coated with inherently porous sol-gel hybrid materials, the accessible surface
area for DFPSE media are enormous leading to a very high sample capacity.In DFPSE, any organic
solvent or solvent mixture can be used as the eluent/back-extraction solvent
since the composite coatings are chemically bonded to the substrate. As a
result, same sample can be analyzed in GC/HPLC/CE if a mutually compatible
solvent is chosen for the back-extraction. Utilization of proper solvent for
back-extraction also ensures no analyte carry-over that may hinders future
extractions or compromises the quality of analytical data. Also, high
enrichment factors obtained in DFPSE eliminates the necessity of time consuming
solvent evaporation and sample reconstitution step.Due to the strong
covalent bonding between the hybrid coating and the substrate, the coating
demonstrates high chemical stability and can be exposed to high acidic (pH 1)
and basic (pH 12) environment without compromising the integrity of the
extraction disk.DFPSE allows user to
use disks coated with polymers of different polarity. As a result, if the
objective of the analytical scheme is to extract analytes with different
polarity, multiple disks coated with different polarity can be employed. At the
end, all extracted analytes can be back-extracted in the same back-extraction
solvent.
Benefit
Fast and highly sensitive sampling and sample preparation capabilityFlexible, highly reproducible, portable and easy to useVery high sample capacity translates into high break-through volumeHigh chemical and solvent stability allows exposure to any organic solvent and aqueous solution with pH ranges of 1-12
Market Application
Collection and preconcentration of target analytes from unmodified sample matrix of chemical, biochemical, pharmaceutical, forensic, clinical, and environmental significance
Brochure
