Abstract
The University of Central Florida invention relates to the
use of NANOG exosomal DNA as a diagnostic cancer marker. Specifically, the marker is a 22bp insert in
the 3’UTR of the NANOG pseudogene, NANOGP8. Exosomes are extracellular
microvesicles (30-100 nm) released by almost all types of cells upon fusion of the
multi-vesicular body with the plasma membrane. Known for their role in cell-to-cell
communication, exosomes have demonstrated an ability to unload their contents
and contribute to the transformation of normal and stem cells to cancerous
states.
Benefit
Exosomes can be obtained from a patient through minimally invasive means such as a blood drawMay further elucidate the mechanisms of cancer formation, progression and metastasisMarket Application
Cancer detection
Brochure
