Abstract
The University of Central Florida invention is a plasmonic biosensor to detect viral infections. Current PCR-based viral detection techniques are slow and tedious, posing technological limitations. Dengue virus type 2 was chosen as a model virus via its nonstructural protein NS1 biomarker. The inventive group has detected the NS1 protein at a concentration of 0.1 – 10 ug/mL in bovine blood using an on-chip microfluidic plasma separator integrated with the plasmonic sensor. This covers the clinical threshold of 0.6 ug/mL of high risk of developing dengue hemorrhagic fever. The conceptual and practical demonstration shows the translation feasibility of these microfluidic optical biosensors for the early detection of a wide range of viral infections, providing a rapid clinical diagnosis of infectious diseases directly from minimally processed biological samples at a point-of-care location.
Benefit
Low-cost testingSimple process with fast resultsBiological samples can be processed at a point-of-care locationMarket Application
Optical biosensors for early detection of a wide range of viral infections
Brochure
