Abstract
Antibiotic resistance is currently an alarming issue and
several health organizations throughout the World have already declared
bacterial resistance towards antibiotics as "catastrophic". The
Infectious Disease Society of America (IDSA) has expressed significant concern
on antibacterial resistance, in particular regarding the multi-drug resistant
bacteria (MDR), which have been singled out as an imminent threat to US public
health. These circumstances have prompted the research community in recent
years to focus on developing alternative chemotherapeutics to combat
antibacterial resistance.FIU inventors have synthesized novel dinuclear silver(I)
pyrazolido complexes that can be used for the treatment of microbial infections
and for the growth inhibition and killing of microbes on surfaces or in
compositions of matter such as food or cosmetics. Slow and sustainable delivery of Ag+ ions under a
physiological milieu by dissociation of the compound is crucial to its
effective antibacterial action, ensuring also that the Ag-based antimicrobial
is not being overused, which might cause other undesirable side effects.
Appropriately designed Ag(I) coordination complexes can meet these requirements;
the introduction of specific ancillary ligands tunes the lability of Ag+
ions and modulates water solubility, facilitating the cellular internalization
process of the therapeutics. Consequently, the latter exert more efficient antibacterial
effect in a lower dosage and accentuate the eradication process of the
pathogens along with the concurrently released bioactive silver from the
respective complexes without inadvertent side-effects.
Benefit
Effective against drug resistant bacterial strainsAttenuate infection without the creation of resistant bacteria or adverse effectsProvide slow release of bioactive silver
Market Application
Creams/patches/bandages to treat burn wounds and other skin infectionsTreatment and prevention of infections caused by multidrug resistant Gram-positive, Gram-negative, fungal, and viral infectionsSurface treatment of surgical instruments, medical and healthcare devices, and food processing
Publications
Syntheses and X-ray crystal structures
of a family of dinuclear silver(I)pyrazolates: Assessment of their
antibacterial efficacy against P. aeruginosa with a soft tissue and skin
infection model; Polyhedron, 154 (2018), pp. 390-397
Brochure
