Abstract
The microextraction capsule (MEC) is capable of extracting target analyte(s)
directly from unaltered sample matrices of biological, chemical, environmental,
food, pharmaceutical, toxicological, and forensic significance containing high
volume of matrix interferents without requiring any sample clean-up approaches
prior to the extraction of the target analyte(s). Due to the high loading of
the extraction sorbent, MEC is capable of handling direct extraction from a
broad range of concentrations of the analyte(s). The sponge-like porous
architecture of the sol-gel hybrid inorganic-organic sorbents used in MEC
results in the achievement of very fast extraction equilibrium. MEC utilizes a
porous membrane to enclose sol-gel derived high efficiency extraction sorbents
that works as a filter to safeguard the integrity of the sorbent and to
permeate the aqueous solution through it for rapid sorbent-analyte interaction. The porous membrane also houses a small magnet in order to rotate the device at
a set speed under the magnetic field and significantly enhances the mass
transfer kinetic between the sample and the micro extraction capsule. The
elution process of extracted analytes can be carried out by exposing the MEC to
high temperatures in a thermal desorption unit followed by purging the released
analytes into the gas chromatography inlet by carrier gas flow or by exposing
the MEC to a small volume of organic solvent to back-extract the analyte which
can be injected into gas chromatography or liquid chromatography for detection
and quantification.
Benefit
Integrates the advanced material properties of sol-gel inorganic/hybrid organic-inorganic polymeric networks offering (i) adjustable porosity; (ii) tunable selectivity; (iii) high thermal and solvent stability; (iv) wide range of pH stability (1-13)Provides a tubular porous membrane capable of retaining and protecting the extraction sorbent while keeping it accessible to the aqueous solution containing the analytes of interestPromotes faster analyte mass transfer by providing a magnetic stirring mechanism resulting in a standalone solvent minimized or solvent-less micro extraction device which provides near exhaustive extraction even under equilibrium extraction conditions
Market Application
This technology is capable of performing efficient extraction and pre-concentration of organic analytes, cations, anions and heavy metals from a variety of sources including:Forensic specimens such as blood, urine, plasma, serum, saliva.Pollutants from environment waterChemical and pharmaceutical samplesDrug or poison residues from biological samplesFood samples
Publications
Samanidou, V., Georgiadis, D., Kabir, A., Furton, K., Capsule phase microextraction:
the total and ultimate sample preparation approach. J. Chromatogr. Sep. Tech. 2018, 9, 1– 4.
Brochure
