Competitive Advantages:
Allows drug to cross the blood-brain barrier,
Decreased toxicity to the kidneys,
Nanoparticle made of a nontoxic, biodegradable materialUSF researchers have developed a nanoparticle-drug system that is capable of delivering higher amounts of MKT-077 to the brain to treat Alzheimer’s disease. The system can be thought of as many tiny pills, made of non-toxic, biodegradable polymers that hold the MKT-077 drug. Putting the drug in this nanoparticle lowers the toxic effects of the drug on the body, and it allows the drug to pass over the BBB to reach the brain. This MKT-077 loaded polymer nanoparticle presents a novel method to treat Alzheimer’s Disease, as well as other neurodegenerative diseases. It may also be effective in the treatment of certain cancers, including melanoma and cancer in the colon, breast, and pancreas.
The Nanoparticle Containing MKT-077 PEG-PGLA is the Polymer Capsule, GSH is a Molecule that Helps in Crossing the BBB
