Competitive Advantages:
Effectively inhibits ALAS, Treats heme biosynthesis disorders and other ALAS related diseases, Easy synthesis and purification technique.
Disclosed herein, are 5-Aminolevulinate synthase inhibitors and methods for their use in the treatment of porphyria. In at least one specific embodiment, the 5-Aminolevulinate synthase inhibitors can include compounds or salts thereof of Formulas (I-V)USF scientists have discovered inhibitors against 5-aminolevulinate synthase. This was achieved via a kinetic target -guided synthesis that was extended to multi-fragment screening with increased throughput. This invention provides novel molecules that are effective in treatment of diseases and metabolic disorders associated with 5-aminolevulinate synthase. It has the potential to treat heme biosynthesis disorder like porphyrias, hepatic disorders, and erythropoietic disorders.
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