Described herein are let-7f miRNA inhibitors and uses thereof. In some embodiments, the let-7f miRNA inhibitors can be capable of reducing method of reducing ??-agonistmediated ??2-Adrenergic Receptor (??2AR) down regulation in a subject in need thereof.We have developed a method to significantly limit beta2-andrenergic receptor downregulation. By inhibiting a specific transcription factor, the upregulation of various microRNA are also inhibited, which then limits the microRNA’s ability to downregulate the beta2-andrenergic receptors. When treated by the aforementioned method, a significant decrease was found in beta2-andrenergic receptor downregulation in cultured human airway smooth muscle (HASM) cells. This novel method may provide a means to maintain the effectiveness of beta-agonist based treatments for pulmonary disorders.
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