The metallothionein gene is transcriptionally regulated by zinc and some other metals and erythrocyte metallothionein protein concentration is an index of dietary zinc status
Proteins encoded by the metallothionein gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in the homeostatic control of metal in the cell, and play a role in the detoxification of heavy metals.
Monoclonal antibodies were raised against purified human metallothionein-1 (hMT-1) and have been used in an ELISA for this protein.
Brochure
