Reduces Children’s Risk of Developing Autism Spectrum Disorder
This new class of probiotic bacteria can protect predisposed children from developing neurodevelopmental disorders, including autism spectrum disorder (ASD). Neurodevelopmental disorders are a group of conditions affecting the development and function of the brain. Autism spectrum disorder, characterized by social difficulties and restricted and repetitive behaviors and interests, affects 1-2% of the population and is one of the most common neurodevelopmental disorders (NDs). NDs can severely affect a person’s quality of life, and studies estimate the lifetime social cost of ASD alone may grow to nearly $15 trillion by 2029. However, there is no available cure or treatment for ASD on the market. Growing evidence highlights certain bacteria in the human gut may play a role in the development of neurodevelopmental disorders. Promoting the growth of beneficial gut bacteria in children may therefore prevent the development of ASD and other NDs.
Researchers at the University of Florida have discovered a class of probiotic bacteria that can protect children from developing autism spectrum disorder (ASD). These bacteria are present at lower levels in infants who are treated with antibiotics and then go on to be diagnosed with ASD later in life. Administering beneficial bacteria to infants as a probiotic can decrease the risk of developing NDs. Additionally, researchers have engineered an amoxicillin-resistant strain able to survive antibiotic treatment. Therefore, these probiotics supplements have the potential to prevent ASD as well as other neurodevelopmental disorders.
Application
Probiotic supplement to prevent neurodevelopmental disorders in children
Advantages
- Antibiotic-resistant strain can better survive antibiotic treatment, helping maintain protective bacteria population
- Probiotic can be administered orally, providing a convenient and controlled dose
- The convergence of infant biomarkers and risk factors in this study provides a foundation for early-life prediction, increasing the potential of intervention in neurodevelopment
Technology
Children prone to developing neurodevelopmental disorders (NDs) have fewer gut bacteria producing equol, an anti-inflammatory metabolite. Equol-producing gut bacteria are also depleted in infants after they are treated with antibiotics, such as in the case of ear infections, which may increase their risk of developing NDs. Researchers at the University of Florida have developed an antibiotic-resistant strain of equol-producing bacteria that can supplement existing gut bacteria to protect children from developing neurodevelopmental disorders, such as autism spectrum disorder (ASD).
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