New Coating for Prosthetic Implants Helps to Reduce Inflammation and Bone Loss

Abstract

UCF researchers have invented a cerium oxide-based coating with anti-inflammatory/anti-oxidant properties that may delay or prevent osteolysis by reducing inflammation and the presence of free radicals while restoring the environment's electrochemical balance.

Although joint replacement surgeries have made remarkable progress, 10-15 percent of surgeries still fail due to high levels of free radicals, chronic inflammation from joint particles or debris generation through wear, and osteolysis (bone loss), or electrochemical dissolution/corrosion, requiring a growing number of revision surgeries. These types of operations are 40 percent more costly than primary total hip and knee arthroplasties, and more than $1 billion are spent on these procedures each year in the United States alone.

Benefit

Market Application