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Manganese Oxide-Coated Nanoparticlesfor Delivery of Genes and siRNA into Brain
Description:

Researchers at the University of South Florida have developed a novel method which delivers genes or small interfering RNA into the brain by nasal insufflations using nanoparticles.

The current method of delivering therapeutic genes or viral vectors into the brain is by minimally invasive neurosurgical injection. For diseases like Huntington’s Disease that involve the entire brain, injection of a viral vector into multiple brain regions over time is not feasible. Furthermore, an additional problem with current methods is the reliance on viral vectors to deliver the gene of interest. Applying these vectors to humans carries a certain amount of risk that can be obviated by using other vehicles for gene delivery such as nanoparticles designed to target specific tissues.

Research Terms: Medical Sciences > Diseases and Disorders > Nervous System Diseases and Disorders
Other
Keywords: Biosciences, Central Nervous System; Biosciences, Drugs;
Technology Information URL: http://www.research.usf.edu//dpl/content/data/PDF/11A020.pdf
University: University of South Florida
Tech Transfer URL: http://www.research.usf.edu/pl/

Associated Patents

Patent Name: Manganese ion coated nanoparticles for delivery of compositions into the central nervous system by nasal insufflation
Patent Number: US Patent 9,375,400
Patent Status: Issued
Issue Date: June 28, 2016
Patent Record: View full record at google patents
View full record at United States Patent and Trademark Office
Patent Inventors:
Patent Name: Manganese ion coated nanoparticles for delivery of compositions into the central nervous system by nasal insufflation
Patent Number: US Patent 9,938,526
Patent Status: Issued
Issue Date: April 10, 2018
Patent Record: View full record at google patents
View full record at United States Patent and Trademark Office
Patent Inventors:

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