Technology Licensing View

Researchers at the University of South Florida have discovered a series of both known and novel gene sequences, which happen to be differentially ex-pressed in LGL leukemia. This technology addresses the use of these gene sequences as molecular markers and their possible utility as novel therapeutic targets for the disease.

T-cell large granular lymphocyte (T-LGL) leukemia is a chronic human lymphoproliferative disorder associated with autoimmune disease. It is one of several types of chronic lymphocytic leukemia, and presents with enlarged lymphocytes with abundant pale cytoplasm containing con-spicuous azurophilic granules (Figure 1). Autoimmune fea-tures are characteristic of this disease, and many of these patients present with the triad of rheumatoid arthritis, neu-tropenia, and an enlarged spleen.