Researchers at the University of South Florida have developed a method of treating colorectal cancer through the enzymatic inhibition of atypical protein kinase C.
Colorectal cancer is the second most common cancer in the world, the third most common cancer in men and second in women worldwide. Death from colorectal cancer accounts for 8 % of all cancer death, making it the fourth common cause of death from cancer. Colorectal cancer is a life threatening dis-ease due to therapy resistant cancerous cells. The exact mechanisms of cell growth, survival, metastasis and inter & intracellular signaling pathways involved in colon cancer are still a major challenge for scientists.
USF scientists have determined the complex mechanism be-hind the proliferation of the cancerous cells and discovered that by inhibiting PKC -iota and PKC-zeta there is significant decrease in colorectal cell proliferation.
In addition to determining the mechanism behind the abnor-mal cell growth, our researchers discovered three inhibitors of atypical protein kinase. These drugs have demonstrated efficacy in blocking colon cancer cell growth and proliferation .
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