Lipid mediators can impact both the initiation and resolution of inflammation in conditions such as arthritis and Crohn’s disease. However, their exact mechanisms are not completely understood. UCF’s Justine Tigno-Aranjuez is studying how a specific receptor and cellular signaling pathway, NOD2, influences the production of lipid mediators.
The NOD2 pathway has been linked to inflammatory conditions such as Crohn’s disease and early onset sarcoidosis (symptoms of which may include pediatric arthritis). “Our hope is that by understanding the molecular events important for the production of such lipid mediators, we can guide therapies in the future that either prevent inflammation or promote its resolution,” says Tigno-Aranjuez.
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