FAU researchers are using the eye lens and retina as models to explore cellular differentiation, function, and disease processes. The team discovered that low oxygen levels are a key driver of cellular reprogramming events leading to formation of mature transparent lens cells.
“Our work will examine the role played by ... hypoxia-inducible transcription factor 1 or HIF1a in control of lens gene expression and the requirement for oxygen-induced epigenetic modifications that regulate DNA conformation,” says Marc Kantorow. The ultimate goal is to use insights from these studies to engineer cell systems and transplantable cells capable of restoring the functions of damaged tissues and organs in other body systems.
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