Expert Profile

John Aris

Associate Professor

ANATOMY AND CELL BIOLOGY | COLLEGE OF MEDICINE

Research Terms & Keywords

Research Terms

Medical Sciences

Industries

Health Care

Research Projects

Ends

Title

07-2014

Evaluation of Weekend Assessments in year 1 of a New Pr Evaluation of Weekend Assessments in year 1 of a New Pr

04-2008

REGULATION OF YEAST LIFE SPAN REGULATION OF YEAST LIFE SPAN

07-2003

EXTRACHROMOSOMAL RDNA CIRCLES: MORE THAN EPISOMES WITH EXTRACHROMOSOMAL RDNA CIRCLES: MORE THAN EPISOMES WITH

05-2002

NUCLEOLAR PROTEIN FUNCTION NUCLEOLAR PROTEIN FUNCTION

06-2001

RESEARCH RESOURCES PROGRAM FOR MEDICAL SCHOOLS RESEARCH RESOURCES PROGRAM FOR MEDICAL SCHOOLS

04-2001

YEAST ALCHOHOL DEHYDROGENASE AND FUNCTIONAL GENOMICS YEAST ALCHOHOL DEHYDROGENASE AND FUNCTIONAL GENOMICS

06-2000

PROLIFERATIONASSOCIATED NUCLEOLAR PROTEINS IN YEAST PROLIFERATIONASSOCIATED NUCLEOLAR PROTEINS IN YEAST

06-2000

NUCLEOLAR FUNCTION and CELL GROWTH IN YEAST NUCLEOLAR FUNCTION and CELL GROWTH IN YEAST

11-1999

NEUROFILAMENT METABOLISM IN EMBRYONIC and MATURE NEURONS NEUROFILAMENT METABOLISM IN EMBRYONIC and MATURE NEURONS

Degrees

Ph.D., Biological Sciences / Biochemistry

Stanford University ▪ 1985
B.S., Biology & Chemistry Majors

Jacksonville University ▪ 1979

Awards & Honors

Exemplary Teacher Award

UF College of Medicine ▪ 2014
Exemplary Teacher Award

UF College of Medicine ▪ 2013
Exemplary Teacher Award

UF College of Medicine ▪ 2012
Exemplary Teacher Award

UF College of Medicine ▪ 2011
Exemplary Teacher Award

UF College of Medicine ▪ 2010
Exemplary Teacher Award

UF College of Medicine ▪ 2009
Exemplary Teacher Award

UF College of Medicine ▪ 2008
Exemplary Teacher Award

UF College of Medicine ▪ 2007
Exemplary Teacher Award

UF College of Medicine ▪ 2006
Exemplary Teacher Award

UF College of Medicine ▪ 2004
NRSA Postdoctoral Fellowship Award

National Institutes of Health ▪ 1985
Predoctoral Fellowship Award

National Science Foundation ▪ 1980
Annual Biology Major Award

Jacksonville University ▪ 1979
Annual Chemistry Major Award

Jacksonville University ▪ 1978

Publications

Publications (in chronological order, asterisk denotes corresponding author)

1. Aris,* JP, AD Eisemann, and L Moulton. 1982. The occurrence of Pugettia richii (Crustacea: Decapoda) on Cystoseira osmundacea follows a diel pattern. Bulletin Marine Sci 32:243-249.

2. Aris, JP, and RD Simoni.* 1983. Cross-linking and labeling of the Escherichia coli F₁F_o-ATP synthase reveal a compact hydrophilic portion of F_o close to an F₁ catalytic subunit. J Biol Chem 258:14599-14609.

3. Aris, JP, DJ Klionsky, and RD Simoni.* 1985. The F_o subunits of the Escherichia coli F₁F_o-ATP synthase are sufficient to form a functional proton pore. J Biol Chem 260:11207-11215.

4. Aris, JP, and RD Simoni.* 1985. The ß subunit of the Escherichia coli ATP synthase exhibits a tight membrane binding property. Biochem Biophys Res Commun 128:155-162.

5. Aris, JP, and G Blobel.* 1988. Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein. J Cell Biol 107:17?31.

6. Aris, JP, and G Blobel.* 1989. Yeast nuclear envelope proteins cross react with an antibody against mammalian pore complex proteins. J Cell Biol 108:2059-2067.

7. Henríquez, R, G Blobel, and JP Aris.* 1990. Isolation and sequencing of NOP1: a yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. J Biol Chem 265:2209-2215.

8. Aris, JP, and G Blobel.* 1991. The isolation of yeast nuclei. Methods Enzymol (Guthrie & Fink, eds) 194:735-749.

9. Aris, JP, and G Blobel.* 1991. cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. Proc Natl Acad Sci USA 88:931-935.

10. Aris, JP, PV Basta, WD Holmes, LM Ballas, C Moomaw, NB Rankl, G Blobel, CR Loomis, and D J. Burns.* 1993. Molecular and biochemical characterization of a recombinant human PKC-delta family member. Biochim Biophys Acta 1174:171-181.

11. Monestier,* M, MJ Losman, KE Novick, and JP Aris. 1994. Molecular analysis of mercury-induced anti-nucleolar antibodies in H-2^S mice. J Immunol 151:667-75.

12. deBeus, E, JS Brockenbrough, B Hong, and JP Aris.* 1994. Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. J Cell Biol 127:1799-1813.

13. Hong, B., JS Brockenbrough, P Wu, and JP Aris.* 1997. Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. Mol Cell Biol 17:378-388.

14. Zimowska, G, JP Aris, and MR Paddy.* 1997. A Drosophila Tpr protein homolog is localized both in the extrachromosomal channel network and to nuclear pore complexes. J Cell Sci 110:927-944.

15. Chen, S, JE Dove, JS Brockenbrough, and JP Aris.* 1997. Homocitrate synthase is located in the nucleus in the yeast Saccharomyces cerevisiae. J Biol Chem 272:10839-10846.

16. Dove, JE, JS Brockenbrough, and JP Aris.* 1998. Isolation of nuclei and nucleoli from the yeast Saccharomyces cerevisiae. (M. Berrios, ed) Methods Cell Biol 53:33-46.

17. Wu, P, JS Brockenbrough, A Metcalfe, S Chen, and JP Aris.* 1998. Nop5p is a small nucleolar ribonucleoprotein component required for pre-18S rRNA processing in yeast. J Biol Chem 273:16453-63.

18. Wu, P, JS Brockenbrough, MR Paddy, and JP Aris.* 1998. NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae. Gene 220:109-117.

19. Oakes, ML, JP Aris, JS Brockenbrough, H Wai, L Vu, and M Nomura.* 1998. Mutational analysis of the structure and localization of the nucleolus in the yeast Saccharomyces cerevisiae. J Cell Biol 143:23-34.

20. Tolerico, LH, AL Benko, JP Aris, DR Stanford, NC Martin, and AK Hopper.* 1999. Saccharomyces cerevisiae Mod5p-II contains sequences antagonistic for nuclear and cytosolic locations. Genetics 151:57-75.

21. Oakes, ML, I Siddiqi, L Vu, JP Aris, and M Nomura.* 1999. Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA. Mol Cell Biol 19:8559-8569.

22. Wu, K, JH Dawe, JP Aris.* 2000. Expression and subcellular localization of a membrane protein related to Hsp30p in Saccharomyces cerevisiae. Biochim Biophys Acta 1463:477-482.

23. Nelson, SA, JP Aris, BKR Patel, and WJ LaRochelle.* 2000. Multiple growth factor transcriptional activation of SAN5, a murine early response gene that complements a lethal defect in yeast ribosome biogenesis. J Biol Chem 275:13835–13841.

24. Fahrenkrog, B, JP Aris, EC Hurt, N Pante, and U Aebi.* 2000. Comparative spatial localization of protein-A-tagged and authentic yeast nuclear pore complex proteins by immunogold electron microscopy. J. Struct Biol 129:295-305.

25. Hong, B, K Wu, JS Brockenbrough, P Wu, and JP Aris.* 2001. Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae. Nucleic Acids Res 29:2927-37.

26. Wu, K, P Wu, and JP Aris.* 2001. Nucleolar protein Nop12p participates in synthesis of 25S rRNA in Saccharomyces cerevisiae. Nucleic Acids Res 29:2938-49.

27. Lu, M, S Vergara, L Zhang, LS Holliday, JP Aris, and SL Gluck.* 2002. The amino-terminal domain of the E subunit of V-ATPase interacts with the H subunit and is required for V-ATPase function. J Biol Chem 277:38409-15.

28. Falcón, AA, and JP Aris.* 2003. Plasmid accumulation reduces life span in Saccharomyces cerevisiae. J Biol Chem 278:41607-41617.

29. Thomson, JM, EA Gaucher, MF Burgan, D DeKee, T. Li, JP Aris, and SA Benner.* 2005. Resurrecting ancestral alcohol dehydrogenases from yeast. Nat Genet 37:630-635.

30. Falcon, AA, N Rios, and JP Aris.* 2005. 2-micron circle plasmids do not reduce yeast life span. FEMS Microbiol Let 250:245–251.

31. Oakes, ML, I Siddiqi, SL French, L Vu, M Sato, JP Aris, AL Beyer, and M Nomura*. 2006. Role of histone deacetylase Rpd3 in regulating rDNA transcription and nucleolar structure in yeast. Mol Cell Biol 26:3889–3901.

32. Urbinati, CR, GB Gonsalvez, JP Aris and RM Long.* 2006. Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit. Mol Genet Genomics 276:369-377.

33. Swanson*, MS, and JP Aris. 2008. Post-transcriptional control: nuclear RNA processing. In Inborn Errors of Development, 2^nd Edition, C. J. Epstein, R. P. Erickson, and A. Wynshaw-Boris, Eds. Oxford University Press. Oxford, UK, pp 1108-1125.

34. Bhabhra, R, DL Richie, HS Kim, WC Nierman, J Fortwendel, JP Aris, JC Rhodes, and DS Askew.* 2008. Impaired ribosome biogenesis disrupts integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus. Eukaryotic Cell 7:575-583.

35. Pafundi, D, C Lee, . Watchman, V Bourke, J Aris, N Shagina, J Harrison, T Fell, and W Bolch.* An image-based skeletal tissue model for the ICRP reference newborn. 2009. Phys Med Biol 54:4497-531.

36. Alvers, AL, LK Fishwick, MS Wood, D Hu, HS Chung, WA Dunn Jr, and JP Aris.* 2009. Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell 8:353-369.

37. Alvers, AL, MS Wood, D Hu, AC Kaywell, WA Dunn Jr, and JP Aris.* 2009. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 5:847-9.

38. Falcon, AA, S Chen, MS Wood, and JP Aris.* 2010. Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae. Mol Cell Biochem 333:99-108.

39. Aris,* JP, MC Elios, E Bimstein, SM Wallet, S Cha, KN Lakshmyya, and J Katz.* 2010. Gingival RAGE expression in calorie restricted versus ad libitum fed rats. J Periodontology 81:1481-7.

40. Seo, AY, A-M Joseph, D Dutta, JCY Hwang, JP Aris*, C Leeuwenburgh. 2010. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123:2533-42.

41. Maynard, MR, JW Geyer, JP Aris, RY Shifrin, W Bolch.* 2011. The UF family of hybrid phantoms of the developing human fetus for computational radiation dosimetry. Phys Med Biol 56:4839-4879.

42. Aris,* JP, LK Fishwick, ML Marraffini, AY Seo, C Leeuwenburgh, and WA Dunn Jr. 2012. Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae. In Aging Research in Yeast. M Brietenbach, P Laun, SM Jazwinski, Eds. Springer, NY. Subcell Biochem. 57:161-86.

43. Aris,* JP, AL Alvers, RA Ferraiuolo, LK Fishwick, A Hanvivatpong, D Hu, C Kirlew, MT Leonard, KJ Losin, M Marraffini, AY Seo, V Swanberg, JL Westcott, MS Wood, C Leeuwenburgh, and WA Dunn Jr. 2013. Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast. Experimental Gerontology 48:1107-1119.

44. Dunn Jr,* WA, LA Schroder, JP Aris. Historical overview of autophagy. 2013. Autophagy and Cancer, Current Cancer Research (vol 8), H-G Wang, Ed, Springer, NY.

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Memberships

National Board of Medical Examiners, Physiology and Cell Biology Test Material Development Committee , Member; 2013 - 2014

UF Anatomy & Cell Biology Faculty Search Committee, Chairperson; 2013 - 2014

Peer Review Positions

Rhode Island Research Alliance (ad hoc), AAAS Research Competitiveness Program ; 2012 - 2012

Annual Meeting Poster Review, International Association of Medical Science Educators; 2012 - 2012

Qatar National Research Fund (ad hoc), Qatar National Research Fund; 2010 - 2010

Research Scholar Award (ad hoc), American Geriatrics Society Foundation; 2010 - 2010

US Civilian Research & Development Foundation (ad hoc), US Civilian Research & Development Foundation ; 2009 - 2009

ETH Zurich Research Commission (ad hoc), ETH Zurich Research Commission; 2008 - 2008

NSF Grant Review (ad hoc), National Science Foundation; 2007 - 2007

NSF Grant Review (ad hoc), National Science Foundation; 2005 - 2005

AHA Grant Review (ad hoc), American Heart Association; 2005 - 2006

ACS Grant Review (ad hoc), American Cancer Society; 1997 - 2001

Other Professional Activities

Postdoctoral Training: 1988-1991, Research Associate, Laboratory of Cell Biology / HHMI, Rockefeller University, NY, NY (advisor, Günter Blobel); 1985-1988, Postdoctoral Fellow, Laboratory of Cell Biology, Rockefeller University, NY, NY (advisor, Günter Blobel). Other positions: 2009-present, Program Director for Education, Department of Anatomy and Cell Biology, UF.