Michael King

82. Tanimura Y, King MA, Williams DK, Lewis MH. Development of repetitive behavior in a mouse model: Roles of indirect and striosomal basal ganglia pathways. Int J Dev Neurosci. 2011 Feb 14. [Epub ahead of print] 81. Ramirez JJ, Poulton WE, Knelson E, Barton C, King MA, Klein RL. Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behav Brain Res. 2011 Jan 1;216(1):332-40. 80. Lee SJ, Sun J, Flint J, Guo S, Xie H, King M, Sarntinoranont M: Optically based indentation technique for acute rat brain slices and thin biomaterials. J Biomed Mater Res Part B: Appl Biomater 97B: 84–95, 2011. 79. Ramirez JJ, Poulton WE, Knelson E, Cole B, King MA, Klein RL: Focal Expression of Mutated Tau in Entorhinal Cortex Neurons of Rats Impairs Spatial Working Memory. Behavioural Brain Research 2010, in press. 78. Zhang Y, Rodrigues E, Gao YX, King M, Cheng KY, Erdös B, Tümer N, Carter C, Scarpace PJ. Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity. Neuroscience. 2010 Sep 15;169(4):1662-71. 77. Flint JJ, Hansen B, Fey M, Schmidig D, King MA, Vestergaard-Poulsen P, Blackband SJ. Cellular-level diffusion tensor microscopy and fiber tracking in mammalian nervous tissue with direct histological correlation. Neuroimage. 2010 Aug 15;52(2):556-61. 76. Parekh MB, Carney PR, Sepulveda H, Norman W, King M, Mareci TH. Early MR diffusion and relaxation changes in the parahippocampal gyrus precede the onset of spontaneous seizures in an animal model of chronic limbic epilepsy. Exp Neurol. 2010; 224(1):258-70. 75. Klein RL, Wang DB, King MA: Versatile somatic gene transfer for modeling neurodegenerative diseases. Neurotox Res. 2009, 16(3):329-42. 74. Flint JJ, Lee CH, Hansen B, Fey M, Schmidig D, Bui DJ, King MA, Vestergaard-Poulson P: Magnetic Resonance Microscopy of Mammalian Neurons. Neuroimage 2009, 46(4): 1037-40. 73. Thinschmidt JS, López-Hernández GY, Ren K, King MA, Meyer EM, Papke RL. Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH-GTS-21, and rAAV-mediated alpha7 nicotinic receptor gene transfer. Brain Res. 2008 Apr 8;1203:51-60. 72. Hirko AC, Meyer EM, King MA, Hughes JA: Peripheral delivery of gelsolin plasmid reduces amyloid beta in depositing transgenic mice. Mol Ther. 2007 Sep;15(9):1623-9. 71. Ren K, King MA, Liu J, Siemann J, Altman M, Meyers C, Hughes JA, Meyer EM. The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice. Neuroscience. 2007 Aug 10;148(1):230-7. 70. Kumar A, Thinschmidt JS, Foster TC, King MA: Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area CA1. J Neurophysiol. 2007 Aug;98(2):594-601. 69. Ren K, Thinshmidt JS, Jiang Liu J, Ai L, Papke RL, King MA, Hughes JA, Meyer EM: ?7 nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation. Neuroscience 2007, 145(1):314-22. 68. Shepherd TM, Özarslan E, Yachnis AT, King MA, Blackband SJ: Diffusion Tensor Microscopy Indicates the Cytoarchitectural Basis for Diffusion Anisotropy in the Human Hippocampus, AJNR Am J Neuroradiol. 2007 May;28(5):958-64. 67. Xiang H, Chen HX, Yu XX, King MA, Roper SN: Reduced excitatory drive in interneurons in an animal model of cortical dysplasia. J Neurophysiol. 2006, 96(2):569-78. 66. Shepherd TM, Ozarslan E, King MA, Mareci TH, Blackband SJ: Structural insights from high-resolution diffusion tensor imaging and tractography of the isolated rat hippocampus. Neuroimage, 2006 Oct 1;32(4):1499-509. 65. Stokely ME, Hwang, S-Y, Hwang, J-Y, Fan B, King MA, Inokuchi K, Koulen P: Polycystin-1 can interact with Homer 1/Vesl-1 in postnatal hippocampal neurons. J Neurosci Res. 2006 Dec; 84(8):1727-37. 64. Gong Y, Meyer EM, Meyers CA; Klein RL, King MA, Hughes JA: Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat. Exp Neurol. 2006, 200(2):371-7. 63. Tartar JL, King MA, Devine DP: Glutamate-Mediated Neuroplasticity in a Limbic Input to the Hypothalamus. Stress, 2006 Mar;9(1):13-9. 62. Erdos B, Broxson CS, King MA, Scarpace PJ, Tumer N. Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulatory nuclei. J Hypertens. 2006 Jan;24(1):109-16. 61. Shepherd TM, Scheffler B, King MA, Stanisz, GJ, Steindler DA, Blackband SJ. MR Microscopy of Rat Hippocampal Slice Cultures: a Novel Model for Studying Cellular Processes and Chronic Perturbations to Tissue Microstructure. Neuroimage 2006, 30(3):780-6. 60. Thinschmidt JS, Frazier CJ, King MA, Meyer EM, Papke RL. Medial septal/diagonal band cells express multiple functional nicotinic receptor subtypes that are correlated with firing frequency. Neurosci Lett. 2005 Dec 9;389(3):163-8. 59. Beck RD Jr, King MA, Ha GK, Cushman JD, Huang Z, Petitto JM: IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins. J Neuroimmunol. 2005 Mar;160(1-2):146-53. 58. Thinschmidt JS, Frazier CJ, King MA, Meyer EM, Papke RL. Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons. Exp Neurol. 2005 Oct;195(2):342-52. 57. Wu K, Meyer EM, Bennett JA, Meyers CA, Hughes JA, King MA. AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy. Brain Res. 2005 Nov 9;1061(2):107-13. 56. Khalil R, King MA, Soliman MR. Testosterone reverses ethanol-induced deficit in spatial reference memory in castrated rats. Pharmacology. 2005 Oct;75(2):87-92. 55. Stokely ME, Yorio T, King MA: Endothelin-1 modulates anterograde fast axonal transport in the central nervous system. J Neurosci Res. 2005, 79(5): 598-607. 54. Deukmedjian AJ, King MA, Cuda C, Roper SN: The GABAergic System of the Developing Neocortex has a Reduced Capacity to Recover from In Utero Injury in Experimental Cortical Dysplasia. J. Neuropathol. Exp. Neurol. 2004, 63(12): 1265-73. 53. Gong Y, Chen S, Sonntag CF, Sumners C, Klein RL, King MA, Hughes JA, Meyer EM: Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia. Brain Res Brain Res Protoc. 2004 Nov;14(1):18-24. 52. Wu K, Meyers CA, Bennett JA, King MA, Meyer EM, Hughes JA: Polyethylenimine-mediated NGF gene delivery protects transected septal cholinergic neurons. Brain Res. 2004, 1008(2): 284-7. 51. Wu K, Meyers CA, Guerra NK, King MA, Meyer EM: The effects of rAAV2-mediated NGF gene delivery into the septum of adult and aged rats. Molecular Therapy 9(2): 262-9, 2004. 50. Klein RL, Lin W-L, Dickson DW, Lewis J, Hutton M, Duff K, Meyer EM, King MA: Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. Am J Pathol. 2004, 164(1): 347-53. 49. Marin-Padilla M, Tsai RJ, King MA, Roper SN: Altered corticogenesis and neuronal morphology in irradiation-induced cortical dysplasia: A Golgi-Cox study. Journal of Neuropathology and Experimental Neurology 2003, 62:1129-1143. 48. Wu K, Klein RL, Meyers CA, King MA, Hughes JA, Millard WJ, Meyer EM: Long Term Neuronal Effects and Disposition of Ectopic PreproNGF Gene Transfer into the Rat Septum. Human Gene Therapy 2003, 14(15): 1463-72. 47. Turner CA, Lewis MH, King MA: Environmental enrichment: Effects on stereotyped behavior and dendritic morphology. Dev. Psychobiol. 2003, 43: 20-27. 46. Thinschmidt JS, Walker DW, King MA: Chronic ethanol treatment reduces the magnitude of hippocampal LTD in the adult rat. Synapse 2003, 48:189–197. 45. Ramirez JJ, Caldwell JL, Majure M, Wessner DR, Klein RL, Meyer EM, King MA: Adeno-associated virus vector expressing nerve growth factor enhances cholinergic axonal sprouting after cortical injury in rats. J. Neuroscience 2003, 23(7): 2797-803,. 44. Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ: Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience 2002, 115(3):879-89. 43. Klein RL, King MA, Hamby ME, Meyer EM: Dopaminergic cell loss induced by human A30Pa-synuclein gene transfer to the rat substantia nigra. Human Gene Therapy 2002, 13: 605–612. 42. Klein RL, Hamby ME, Gong Y, Hirko AC, Wang S, Hughes JA, King MA, Meyer EM: Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain. Exp Neurol. 2002, 176(1): 66-74. 41. Miller R, King M, Heaton M, Walker D: The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Brain Res. 2002, 950(1-2): 13. 40. Li Y, Meyer EM, Walker DW, Millard WJ, He YJ, King MA: Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome C release and neurotoxicity in primary rat hippocampal neuronal cultures. Neurochem. 2002, 81(4): 853-8. 39. Beck RD, King MA, Huang Z, Petitto JM: Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain Res. 2002, 955(1-2): 16-23. 38. Klein RL, Hamby ME, Sonntag CF, Millard WJ, King MA, Meyer EM: Measurements of vector-derived neurotrophic factor and green fluorescent protein levels in the brain. Methods 2002, 28(2): 286-92. 37. King MA, Scotty N, Klein RL, Meyer EM: Particle detection, number estimation, and feature measurement in gene transfer studies: optical fractionator stereology integrated with digital image processing and analysis. Methods 2002, 28(2): 293-9. 36. Shi J, Bui JD, Yang SH, He Z, Lucas TH, Buckley DL, Blackband SJ, King MA, Day AL, Simpkins JW: Estrogens decrease reperfusion-associated cortical ischemic damage: an MRI analysis in a transient focal ischemia model. Stroke 2001, 32(4): 987-92. 35. Ajmani PS, Wang W, Tang F, King MA, Meyer EM, Hughes JA: Transgene delivery with a cationic lipid in the presence of amyloid beta (betaAP) peptide. Neurochem Res. 2001, 26(3): 195-202. 34. Li Y, Walker DW, King MA: Hydrogen peroxide mediates ethanol-induced cytotoxicity in PC12 cells. Free Rad. Biol. Med. 2001, 30(4): 389-92. 33. He Z, Yang SH, Naritomi H, Yamawaki T, Liu Q, King MA, Day AL, Simpkins JW: Definition of the anterior choroidal artery territory in rats using intraluminal occluding technique. J. Neurol. Sci. 2000, 182: 16-28. 32. Murray KD, Isackson PJ, Eskin TA, King MA, Montesinos SP, Abraham LA, Roper SN: Altered mRNA expression for brain-derived neurotrophic factor and calcium/calmodulin-dependent protein kinase type II in the hippocampus of patients with intractable temporal lobe epilepsy. J Comp Neurol 2000, 418(4): 411-22. 31. Wang S, Bui V, Hughes JA, King MA, Meyer EM: Adeno-associated virus mediated gene transfer into primary rat brain neuronal and glial cultures: enhancement with the pH-sensitive surfactant dodecyl 2-(1'-imidazolyl) propionate. Neurochem Int. 2000, 37(1): 1-6. 30. Li Y, King MA, Meyer EM: Alpha7 nicotinic receptor mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells. Brain Res. 2000, 861: 165-7. 29. Li Y, King MA, Grimes J, Smith N, de Fiebre CM, Meyer EM: a7 nicotinic receptor mediated protection against ethanol-induced cytotoxicity in PC12 cells. Brain Res. 1999, 816: 225-8. 28. Klein RL, McNamara RK, King MA, Lenox RH, Muzyczka N, Meyer EM: Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer. Brain Res 1999, 832: (1-2) 136-44. 27. Roper SN, Eisenschenk S, King MA: Reduced density of parvalbumin- and calbindinD28k-immunoreactive neurons in experimental cortical dysplasia. Epilepsy Res. 1999, 37(1):63-71. 26. Klein RL, Muir D, King MA, Peel AL, Zolotukhin S, Moller JC, Kruttgen A, Heymach JV, Muzyczka N, Meyer EM: Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and trk receptor levels in the adult rat basal forebrain. Neuroscience 1999, 90(3): 815-21. 25. Thinschmidt JS, Webb B, Martin DE, Feldman DH, King MA, Walker DW: The development and pharmacological characterization of calcium channel currents in cultured embryonic rat septal cells. Brain Res Dev Brain Res. 1999, 118(1-2): 13-21. 24. Panickar KS, Purushotham K, King MA, Rajakumar G, Simpkins JW: Hypoglycemia-induced seizures reduce cyclic AMP response element binding protein levels in the rat hippocampus. Neurosci. 1998, 83(4): 1155-60. 23. Meyer EM, King MA, Meyers C: Neuroprotective effects of 2,4-dimethoxybenzylidene anabaseine (DMXB) and tetrahydroaminoacridine (THA) in neocortices of nucleus basalis lesioned rats. Brain Res. 1998, 786: 252-5. 22. Meyer EM, Tay ET, Zoltewicz JA, Meyers C, King MA, Papke RL, deFiebre CM: Neuroprotective and memory-related actions of novel a7 nicotinic agents with different mixed agonists/antagonist properties. J. Pharm. Exp. Ther. 1998, 284: 1026-32. 21. Roper SN, Moores MD, Gelikonov GV, Feldchtein FI, Beach NM, King MA, Gelikonov VM, Sergeev AM, Reitze DH: In vivo detection of experimentally induced cortical abnormalities in the adult rat neocortex using optical coherence tomography. J. Neurosci. Meth. 1998, 80: (1) 91-98. 20. Klein Rl, Peel AL, Meyers C, Zolotukhin S, Muzyczka N, Meyer EM, King MA: Neuron-specific transduction in rat septohippocampal or nigro-striatal pathway by recombinant adeno-associated virus vectors. Exp. Neurol. 1998, 150: 183-94. 19. Peris J, Anderson KJ, Vickroy TW, King MA, Hunter BW, Walker DW: Neurochemical basis of disruption of hippocampal long term potentiation by chronic alcohol exposure. Frontiers in Bioscience 1997,2: d309-16. 18. King MA, Thinscmidt J, Walker DW: Gammahydroxybutyrate (GHB) ligand effects on evoked field potentials in CA1 of the rat acute hippocampal slice. J. Neural Trans. 1997, 104: 1177-93. 17. Panickar KS, Guan G, King MA, Rajakumar G, Simpkins JW: 17-b-estradiol attenuates CREB decline in the rat hippocampus following seizure. J. Neurobiol. 1997, 33(7): 961-7. 16. Rabbani O, Panickar KS, Rajakumar G, King MA, Bodor N, Meyer EM, Simpkins JW: 17-b-estradiol attenuates fimbrial lesion-induced decline of ChAT immunoreactive neurons in the rat medial septum. Exp. Neurol. 1997 146: 179-86. 15. Roper SN, King MA, Abraham LA, Boillot MA: Disinhibited in vitro neocortical slices containing experimentally induced cortical dysplasia demonstrate hyperexcitability. Epilepsy Res. 1997, 26: 443-9. 14. Swanson DJ, Tonjes L, King MA, Walker DW, Heaton MB: The influences of chronic prenatal ethanol on cholinergic neurons of the septohippocampal system. J. Comp. Neurol. 1996, 364(1): 104-12. 13. Wu P, Wang S, deFiebre CM, Millard WJ, King MA, Meyer EM: An AAV-mediated gene delivery system for neuropeptide Y in neurons and rat brain. Gene Therapy 1996, 3: 246-253. 12. Swanson DJ, King MA, Walker DW, Heaton MB: Chronic prenatal ethanol exposure alters the normal ontogeny of choline acetyltransferase activity in the rat septohippocampal system. Alc. Clin. Exp. Res. 1995, 19: 1252-60. 11. Webb B, Heaton MB, King MA, Walker DW: Labelling embryonic rat medial septal region projection neurons in vitro using fluorescent tracers. Brain Res. Bull. 1995, 37(3): 317-23. 10. Martin EJ, Panikar KS, King MA, Deyrup M, Hunter BE, Meyer EM: Cytoprotective actions of 2,4-methoxybenzilidene anabaseine in differentiated PC12 cells and septal neurons. Drug Devel. Res. 1994, 31: 135-141. 9. Walker DW, Heaton MB, Lee N, King MA, Hunter BE: The effect of chronic ethanol on the septohippocampal system: A role for neurotrophic factors? Alc. Clin. Exp. Res. 1993, 17: 12-18. 8. Walker DW, Lee N, Heaton MB, King MA, Hunter BE: Chronic ethanol consumption reduces the neurotrophic activity in rat hippocampus. Neurosci. Lett. 1992, 147: 77-80. 7. Walker DW, Heaton MB, King MA, Lee N, Hunter BE: Chronic ethanol-induced reduction in hippocampal neurotrophic activity persists after long-term abstinence. Alc. Clin. Exp. Res. 1992, 17: 12-18. 6. King MA, Walker DW, Hunter BE, Reep RL: Acetylcholinesterase stain intensity patterns in the rat dentate gyrus: A quantitative description based on digital image analysis. Neurosci. 1989, 33: 203-231,. 5. King MA, Louis PM, Hunter BE, Walker DW: Biocytin: A versatile anterograde neuroanatomical tract-tracing alternative. Brain Res. 1989, 497: 361-367. 4. King MA, Walker DW, Hunter BE: Alterations and recovery of dendritic spine density in rat hippocampus following long-term ethanol ingestion. Brain Res. 1988, 459: 381-385. 3. King MA: A software package for automated analysis of digitized field potentials, analysis and display of laminar field potential profiles, and computation and display of current source-density maps. Neurosci. 1987, 20:I. 2. King MA: Recovery and Recoverability in the Central Nervous System Following Long Term Ethanol Consumption. Doctoral dissertation, University of Florida, 1985. 1. King MA, Reep RL, Hunter BE, Walker DW: The three dimensional pattern of afferent terminal lamination onto dentate granule cells in the rat revealed with quantitative stain band morphometry: Sinusoidal fluctuations. J. Comp. Neurol. 1985, 234: 334-343,.