Jianning Wei

Abstract

Current methods for single-cell analysis, such as Electrical Impedance Spectroscopy (EIS) and optical tweezers, are limited to measuring either electrical or mechanical properties, not both. While EIS provides insights into electrical characteristics and optical tweezers assess mechanical attributes, neither approach can simultaneously capture both types of data. This separation results in incomplete cellular profiles and requires complex, low-throughput setups. There is a critical need for a solution that unifies these measurements to offer a comprehensive view of cellular health without the need for invasive labeling or extensive sample preparation.

Researchers at Florida Atlantic University have developed an innovative Electro-Deformation Spectroscopy (EDS) system that addresses the limitations of existing single-cell analysis methods. This technology combines electrical and mechanical measurements into a single, high-throughput platform, enabling simultaneous assessment of both properties without the need for labeling or complex setups. The EDS system utilizes a microfluidic device with embedded microelectrodes to induce electro-deformation in cells, capturing comprehensive data on cell health and function in a more efficient and accessible way. Currently, the EDS system is in the preclinical development stage, with ongoing studies to validate its effectiveness across a variety of cell types and conditions.

FAU seeks to advance this innovation into the marketplace through licensing or development partnerships.

Benefit

Market Application

Publications

Electro-Deformation Spectroscopy of Biological Cells

Electro-Deformation Spectroscopy: A Unified Method for Simultaneous Electrical and Mechanical Characterization of Single Cells