Research Terms
Neurosciences Neurology Neuropharmacology Health Promotion
Keywords
Acute Ischemic Infarct Chocolate Cocoa Concussion Hemorrhagic Stroke Ischemia Ischemic Stroke Personalized Medicine Red Wine Sickle Cell Disease Stroke Subarachnoid Hemorrhage Traumatic Brain Injury
Industries
Publications, Peer-Reviewed Original Research (*equal contribution)
1. Lo CF, Liu L, Chu B-H, Ren F, Pearton SJ, Doré S, Hsu C-H, Kim J, Dabiran AM, Chow PP. Carbon monoxide detection sensitivity of ZnO nanorod-gated AlGaN/GaN high electron mobility transistors in different temperature environments. J. Vac. Sci. Technol. B 30(1):1-4, 2012
2. Zhen G, Kim YT, Li RC, Yocum J, Kapoor N, Langer J, Dobrowolski P, Maruyama S, Narumiya S, Doré S. PGE2 EP1 receptor exacerbates neurotoxicity in mouse cerebral ischemia and Alzheimer’s disease. Neurobiology of Aging, 33:2015-19, 2012. PMID: 22015313.
3. Kim YT, Moon SK, Maruyama T, Narumiya S, Doré S. Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity. Neurobiol Dis. 48:58-65, 2012. PMID: 22709986.
4. Fong Lo C, Xi Y, Liu L, Pearton S, Doré S, Hsing Hsu C, Dabiran A, Chow P, Ren F. Effect of temperature on CO sensing response in air ambient by using ZnO nanorod-gated AIGaN/GaN high electron mobility transistors. Sensors and Actuators B Chemical. January 2013.
5. Doré S, Sampie K, Goto S, Alkayed N, Guastella D, Blackshaw S, Gallagher M, Traystman R, Hurn P, Koehler R, Snyder S. Heme oxygenase-2 is neuroprotective in cerebral ischemia (vol 5, pg 656, 1999). Molecular Medicine. June 2013.
6. Ahmad AS, Maruyama T, Narumiya S, Doré S. PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: Old switch, new Target. Neurotox Res. 23(3):260-6, 2013.
7. Singh N, Ma B, Leonardo C, Ahmad AS, Narumiya S, Doré S. Role of PGE2 EP1 receptor in intracerebral hemorrhage induced brain injury. Neurotox Res. 24:549-59, 2013. PMID: 23824501.
8. Leonardo CC, Agrawal M, Singh N, Moore JR, Biswal S, Doré S, Oral administration of the flavanol (–)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway. Eur. J. Neuroscience 38:3659-68, 2013. PMID: 24112193
9. Faraday N, Schunke K, Saleem S, Fu J, Wang B, Zhang J, Morrell C, Doré S. Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. PLoS One. 8(8):e71447, 2013.
10. Mohan S., Glushakov AV, deCurnou A, Narumiya S, Doré S. Contribution of PGE2 EP1 receptor in hemin-induced neurotoxicity. Front. Mol. Neurosci. 6:31, 2013. PMID: 24109429
11. Mendez NV, Wharton JA, Leclerc JL, Blackburn SL, Douglas-Escobar MV, Weiss MD, Seubert CN, Doré S. Clinical implications of bilirubin-associated neuroprotection and neurotoxicity. Intl. J. Clin. Anesth. 1(2): 1013, 2013
12. Glushakov AV, Robbins SW, Bracy CL, Narumiya S, Doré S. Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury. J. Neuroinflammation 10:132, 2013.
13. Liu S, Zhen G, Li RC, Doré S. Acute bioenergetic intervention or pharmacological preconditioning protects neuron against ischemic injury. J Exp Stroke Transl Med. 6:7-17, 2013.
14. Hawkins KE, DeMars KM, Singh J, Yang C, Cho HS, Frankowski JC, Doré S, Candelario-Jalil E. Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke. J. Neurochemistry, 129:130-42, 2014. PMID: 24225006.
15. Bickford JS, Ali NF, Nick JA, Al-Yahia M, Beachy DE, Doré S, Nick H, Waters, M. Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism. Brain Res., 1588:25–36, 2014
16. Glushakov AV, Fazal J, Doré S. Role of the prostaglandin E2 EP1 receptor in traumatic brain injury. PLOS One 9(11):e113689, 2014.
17. Mohan S., Narumiya S, Doré S. Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Neurotoxicology 46:53-9, 2015.
18. Rastogi C, Santiago-Moreno J, Doré S. Ginseng: A promising neuroprotective strategy in stroke. Frontiers in Cellular Neuroscience, 8:457-67, 2015.
19. Leclerc JL, Blackburn S, Neal D, Mendez NV, Wharton JA, Waters MF, Doré S. Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage. Proc Natl Acad Sci USA 112:1155-60, 2015.
20. Leonardo CC, Mendes M, Ahmad AS, Doré S. Efficacy of prophylactic flavan-3-ol in permanent focal ischemia in twelve-month-old mice. Am. J Physiol. Hearty Circ Physiol 308:H583-91, 2015.
21. Leclerc JL, Lampert AS, Diller MA, Immergluck JB, Doré S. Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recovery. ASN Neuro 7(2) 1759091415578713, 2015.
22. Leclerc JL, Lampert AS, Diller, MA, Doré S. Genetic deletion of the PGE2 EP3 receptor improves anatomical and functional outcomes after intracerebral hemorrhage. Eur. J Neuroscience 41:1381-91, 2015.
23. Glushakov A, Doré S. Hippocampal degeneration after traumatic brain injury: The role of the PGE2 EP1 receptor. J. Trauma and Care, 1(2):1007, 2015.
24. Ahmad AS, Satriomoto I, Fazal JA, Nadeau SE, Doré S. Considerations for the optimization of induced white matter injury preclinical models. Frontiers Neurol., 6:172, P1-13, 2015.
25. Ahmad AS, Satriomoto I, Fazal JA, Nadeau SE, Doré S. Optimization of a clinically relevant model of white matter stroke in mice: Histological and functional evidences. J Neurol Neurosurg 2:114, 2015.
26. Leclerc J, Ahmad AS, Singh N, Soshnik-Schierling L, Greene E, Dang A, Doré S. Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor. BMC Neuroscience. 16:48, 2015. PMID: 26232001.
27. Doré S, Ahmad AS. Cytoprotective role of prostaglandin D2 DP1 receptor against neuronal injury following acute excitotoxicity and cerebral ischemia. Brain Neurotrauma, 10:1-25, 2015.
28. Frankowski JC, DeMars KM, Ahmad AS, Hawkins KE, Yang C, Leclerc JL, Doré S, Candelario-Jalil E. Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke. Science Report 5:17956, 2015.
29. Ma B, Day J, Tolosano E, Doré S. Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. J. Neuroinflam. 12:26, 2016
30. Leclerc J, Lampert AS, Diller MA, Doré S. PGE2-EP3 signaling exacerbates intracerebral hemorrhage outcomes in 24-mo-old mice. Am J Physiol 310:H1725-34, 2016.
31. Ahmad AS, Shah Z, Doré S. Protective role of arginase II in cerebral ischemia and excitoxicity. J Neurol Neurosci 7(2):88, 2016.
32. Glushakov AV, Arias RA, Tolosano E, Doré S. Age-dependent effects of haptoglobin deletion in neurobehavioral and anatomical outcomes following TBI. Front. Mol. Biosci., 3:24, 2016.
33. Glushakov AV, Glushakova OY, Doré S, Carney PR, Hayes RL. Animal models of posttraumatic seizures and epilepsy. Methods Mol Biol. 1462:481-519, 2016.
34. Leclerc JL, Santiago-Moreno J, Dang A, Lampert AS, Cruz PE, Rosario AM, Golde TE, Doré S. Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage. J Cereb Blood Flow & Metab. In Press. 2016.
35. Garcia JM, Stillings SA, Leclerc JL, Edwards NJ, Robicsek SA, Hoh BL, Blackburn S, Doré S. Role of interleukin-10 in acute brain injuries. Front. Neurol. In Revision, 2017.
36. Leclerc JL, Lampert AS, Loyola CA, Schlakman B, Vasilopolous T, Svendsen P, Moestrup SK, Doré S. The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes. J Cereb Blood Flow & Metab. In Press, 2017.
American Society of Epilepsy, Member; 2011 - 2012
Integrative Practitioner, Member; 2008 - 2011
American Heart Association, Member; 2003 - 2018
Internation Society for Cerebral Blood Flow and Metabolism, Member; 2000 - 2018
National Stroke Association, Member; 2000 - 2011
American Association for the Advancement of Science, Member; 1997 - 2011
American Society for Neuroscience, Member; 1994 - 2018
Grant, NIH; 2011 - 2011
Grant, EU Community Centers for Excellence; 2011 - 2011
Grant, Canadian Institute of Health Research - Alzhemiers; 2011 - 2011
Grant, Canadian Institute of Health Research; 2010 - 2010
Grant, Qatar National Research Fund; 2010 - 2010
Grant, Pennsylvaina Department of Health; 2010 - 2010
Grant, Alzheimer's Disease and Related Disorders (France); 2010 - 2010
Grant, AHA; 2010 - 2011
Grant, NIH; 2010 - 2010
Grant, NIH; 2009 - 2009
Grant, Johns Hopkins University of Medicine; 2008 - 2009
Grant, Canadian Institute of Health Research; 2006 - 2010
Grant, NINDS; 2005 - 2011
Grant, CRSNG; 2005 - 2005
Grant, McGill University; 2005 - 2005
Grant, AHA; 2004 - 2008
Grant, NCCAM; 2004 - 2004
Grant, Canadian Institute of Health Research; 2003 - 2003
Grant, VA Merit Review Boards; 2003 - 2004
Grant, NIH; 2003 - 2005
Grant, Canadian Institute of Health Research; 2003 - 2004
Grant, Scottish Rite Charitable Foundation; 2002 - 2005
Grant, Heart and Stroke Foundation; 2002 - 2002
Grant, The Hospital for Sick Children Foundation; 2001 - 2001
Grant, Alzheimer's Association; 2001 - 2010
Grant, AHA; 2000 - 2004
Grant, VA; 2000 - 2000
Grant, Alzheimer Society of Canada; 1999 - 2004
Grant, NSF; 1997 - 2006
Discussion about the potential heath benefits of red wine and/or dark chocolate. Review of the mechanisms involved!
Subject Areas:
Keywords:
Audience:
Adults
Duration:
1 hour or less
Fee:
Expenses Only
Introduction on the various types of stroke, review some of the current treatments and discuss about novel therapies that may become available through ongoing research effort.
Subject Areas:
Audience:
Adults
Duration:
1 hour or less
Fee:
Expenses Only
Center for Translational Research in Neurodegenerative Disease 1275 CENTER DR, BMS J493 GAINESVILLE, FL 32608