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Stephen Liggett

Assoc VP, Usf Health & Duhp

MORSANI COLLEGE OF MEDICINE | MORSANI COLLEGE OF MEDICINE

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Ends

Title

06-2027

Targeting T2 inflammation-evoked mechanical endotypes of Targeting T2 inflammation-evoked mechanical endotypes of

Rutgers University

08-2025

Quantum enhanced olfactory sensors Quantum enhanced olfactory sensors

University of Arizona

08-2025

Characterization of biased airway smooth muscle TAS2R ag Characterization of biased airway smooth muscle TAS2R ag

National Heart, Lung, and Blood Institute

08-2025

Characterization of biased airway smooth muscle TAS2R ag Characterization of biased airway smooth muscle TAS2R ag

National Institutes of Health

12-2023

Effects of Rare Genetic Variants and Ancestry on Beta Ag Effects of Rare Genetic Variants and Ancestry on Beta Ag

Mayo Clinic

11-2023

Effects of Rare Genetic Variants and Ancestry on Beta Ag Effects of Rare Genetic Variants and Ancestry on Beta Ag

Wake Forest University

08-2021

Molecular Properties of B-Adrenergic Receptors in Asthma Molecular Properties of B-Adrenergic Receptors in Asthma

National Heart, Lung, and Blood Institute

07-2020

Novel Molecular Mechanisms Promote GPCR-Induced Bronchod Novel Molecular Mechanisms Promote GPCR-Induced Bronchod

Rutgers University

06-2020

Molecular Properties of B-Adrenergic Receptors in Asthma Molecular Properties of B-Adrenergic Receptors in Asthma

National Institutes of Health

09-2017

USF Heart Health Institute Grant USF Heart Health Institute Grant

Hillsborough County

06-2017

Novel Molecular Mechanisms Promote GPCR-Induced Bronchod Novel Molecular Mechanisms Promote GPCR-Induced Bronchod

Rutgers University

07-2014

Basis of Variability of Lung GPCR Signaling Basis of Variability of Lung GPCR Signaling

National Heart, Lung, and Blood Institute

06-2014

Novel Molecular Mechanisms Promote GPCR-Induced Broncho Novel Molecular Mechanisms Promote GPCR-Induced Broncho

University of Pennsylvania

12-2013

Lung HRV: G-Protein Coupled Signaling Interactions in Asthma Lung HRV: G-Protein Coupled Signaling Interactions in Asthma

National Heart, Lung, and Blood Institute

06-2013

Pharmacogenetics of Asthma Treatment - Administrative Core Pharmacogenetics of Asthma Treatment - Administrative Core

Brigham & Women's Hospital, Inc.

02-2013

Molecular Properties of B-Andrenergic Receptors in Asthma Molecular Properties of B-Andrenergic Receptors in Asthma

National Heart, Lung, and Blood Institute

Publications

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Center

Center for Personalized Medicine and Genomics

Director	Stephen Liggett
Phone	813-974-7715
Website	https://health.usf.edu/research/liggett_lab/
Mission	The center brings together faculty investigators and other personnel with a mission to study the molecular basis of human disease and its treatment as they relate to genomic variation, leading to personalized medicine. These endeavors utilize genomic information from patients and/or experimental systems. The goals of such investigations are to harness genomic information and its variation in humans or experimental systems to: 1) devise methods to tailor medical care for prediction of disease rise, prognosis, and treatment and 2) to identify novel pathways relevant to mechanism of disease and drug targets.

USF Health Heart Institute

Director	Stephen Liggett
Phone	813-396-9713
Website	https://health.usf.edu/medicine/heart-institute
Mission	Establish a multidisciplinary research unity which will increase USF research productivity, research funding, and national research presence.

Technologies

A Method to Reduce Beta2-Adrenergic Receptor Downregulation

Described herein are let-7f miRNA inhibitors and uses thereof. In some embodiments, the let-7f miRNA inhibitors can be capable of reducing method of reducing ??-agonistmediated ??2-Adrenergic Receptor (??2AR) down regulation in a subject in need thereof.We have developed a method to significantly limit beta2-andrenergic receptor downregulation. By inhibiting a specific transcription factor, the upregulation of various microRNA are also inhibited, which then limits the microRNA’s ability to downregulate the beta2-andrenergic receptors. When treated by the aforementioned method, a significant decrease was found in beta2-andrenergic receptor downregulation in cultured human airway smooth muscle (HASM) cells. This novel method may provide a means to maintain the effectiveness of beta-agonist based treatments for pulmonary disorders.