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Thayumanasamy Somasundaram

Sr Research Associate

INST OF MOLECULAR BIOPHYSICS | FLORIDA STATE UNIVERSITY

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Publications
Activities
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Websites
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Research Terms & Keywords

Research Terms

Computer Software Life Sciences Proteins Biophysics Crystallography Electronic Equipment and Devices Biological Instrumentation Microscopy Research Tools

Keywords

Biophysics Cryo Crystallography Crystal Structure Macromolecular Crystallography Powder X-Ray Diffraction Protein Crystallization Protein Structure Robotic Imaging Single Crystal Diffraction Structural Biology Synchrotron Data Collection X-Ray Diffraction

Industries

Microelectronics & Computer Products Medical Devices Specialized Logistics IT

Research Projects

Ends

Title

01-2017

Density Gradient Fractionator for Biological Molecule Sample Preparation Density Gradient Fractionator for Biological Molecule Sample Preparation

FSU EIEG Award

05-2015

EIEG: Crystallization Robot For X-Ray Crystallography Facility EIEG: Crystallization Robot For X-Ray Crystallography Facility

FSU EIEG Award

08-2012

Acquisition of Rigaku Automated Detector and X-Ray Generator System Acquisition of Rigaku Automated Detector and X-Ray Generator System

FSU EIEG Award

Degrees

Ph.D., Physical Chemisty

Indian Institute of Science, Bangalore, India ▪ 1987
M.S., Chemistry

University of Madras, Chennai, India ▪ 1981

Awards & Honors

Distinguished University Scholar

Florida State University (FSU) ▪ 2021
Prudential Productivity Awards

Florida Tax Watch ▪ 2017

Publications

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121240/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258611/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660625/
‘FSU Scientific Asset Management‘, Third Florida Core Network Event, Aug 11, 2016, FSU, Tallahassee, FL
‘Low-cost home-built imager for protein screening‘, 66^th Annual Meeting, American Crystallographic Association, Denver, CO, Jul 22-26, 2016.

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Memberships

Association of Biomolecular Research Facilities, President; 2024 - 2025

Southeastern Association of Shared Resources, Treasurer; 2016 - 2018

Leon County Science Advisory Committee, Member; 2015 - 2018

American Crystallographic Association, Member; 2000 - present

Peer Review Positions

Synchrotron Beam Line Renewal, United States Depatment of Energy; 2015 - 2015

Professional Presentations

Why You Need a X-Ray Facility?; 2015 Florida Core Network Event; Moffitt Cancer Center, Tampa, Florida.; 2015

Funding/Upgrading for Mid-size Equipment; 2016 Pittcon Conferee Network; Pittcon; 2016

Low-cost home-built imager for protein crystal screening; 2016 Annual Meeting of ACA; American Crystallographic Association; 2016

FSU IMB Core Facilities; 2014 Florida Core Network Event; UF-ICBR, Gainesville, Florida.; 2014

Effective Communication in the world of Shared Resources; 2013 Annual Meeting; Southeastern Association of Shared Resources; 2013

Measuring Shared Resource Impact; 2017 Annual Meeting; Southeatern Association of Shared Resources; 2017

FSU Scientific Asset Management; 2016 Florida Core Network Event; Florida State University, Tallahassee, FL; 2016

Scientific Equipment Web Portal; 2017 Post-doctoral Symposium; FSU Office of Postdoctoral Affairs; 2017

Other Professional Activities

Poster Judge, 2014 American Crystallographic Association Annual Meeting Albuquerque, NM

Videos

Duration: 1:46

Simple low cost protein crystal imager data collection demo mode

This demonstrates the Simple Robotic Imager for the protein crystal screening. In this demo we are showing homing of the imager, camera function, and data collection.

Year:

2015

Link:

https://www.youtube.com/watch?v=VElpTthNKxc

Source:

youtube

Keywords:

robotic imager protein imager crystal imager demo

Duration: 0:56

Simple Robotic Imager Homing and Right and Left Demo mode

This demonstrates the Simple Robotic Imager for the protein crystal screening. In this demo we are showing homing of the imager, camera function, right and left movement. No image recording is shown.

Year:

2015

Link:

https://www.youtube.com/watch?v=-J5wnu6M-qI

Source:

youtube

Keywords:

robotic imager homing crystals G-code

Duration: 1:10

Simple Robotic Imager Homing and Up and Down modes

This demonstrates the Simple Robotic Imager for the protein crystal screening. In this demo we are showing homing of the imager, camera function, up and down movement. No image recording is shown.

Year:

2015

Link:

https://www.youtube.com/watch?v=5w99pCLYcVI

Source:

youtube

Keywords:

Imager Robot crystals.

Duration: 0:35

Simple Robotic Imager Image Preview Demo Mode

This demonstrates the Simple Robotic Imager for the protein crystal screening. In this demo we are showing the preview of the camera function only. No movement of the imager is shown.

Year:

2015

Link:

https://www.youtube.com/watch?v=oUei9g3lpbY

Source:

youtube

Keywords:

Simple robotic imager protein crystals crystallizaton

Duration: 0:20

Low Cost Robotic Imager Imaging Mode

Imaging mode demonstration of a low cost robotic imager for protein crystallization screening plates (96-reservoir plates)

Year:

2015

Link:

https://www.youtube.com/watch?v=0PvBg_uJdww

Source:

youtube

Keywords:

Imager Protein crystals

Duration: 0:47

Low Cost Imager Demonstration

Low cost robotic imager for protein crystallization screening plates (96-reservoir plates)

Year:

2015

Link:

https://www.youtube.com/watch?v=hBWadsf-zQ8

Source:

youtube

Keywords:

96-well plates imager robotic imager

Duration: 0:31

ARI Crystal Gryphon Step 5

ARI Crystal Gryphon Crystallization Robot. Step 5

Year:

2014

Link:

https://www.youtube.com/watch?v=RbPiJ9vc218

Source:

youtube

Keywords:

Crystal Gryphon

Duration: 1:34

ARI Crystal Gryphon Step 4

ARI Crystal Gryphon Crystallization Robot. Step 4

Year:

2014

Link:

https://www.youtube.com/watch?v=9W9K8EEZXbQ

Source:

youtube

Keywords:

Crystal Gryphon

Duration: 1:46

ARI Crystal Gryphon Step 3

ARI Crystal Gryphon Crystallization Robot. Step 3

Year:

2014

Link:

https://www.youtube.com/watch?v=EfQfj1tm2eg

Source:

youtube

Keywords:

Crystal Gryphon

Duration: 4:02

ARI Crystal Gryphon Step 2

ARI Crystal Gryphon Crystallization Robot. Step 2

Year:

2014

Link:

https://www.youtube.com/watch?v=XRlsIeHOWVs

Source:

youtube

Keywords:

Crystal Gryphon

Duration: 2:33

ARI Crystal Gryphon Step 1

ARI Crystal Gryphon Crystallization Robot. Step 1

Year:

2014

Link:

https://www.youtube.com/watch?v=CdEMm0dD_Rg

Source:

youtube

Keywords:

Crystal Gryphon

Duration: 03:24

Crystal Gryphon Protein Crystal Set-up

FSU X-Ray Facility's ARI Crystal Gryphon Crystallization Robot is used to set-up 96-reservoir (Intelliplate 96-3) 3-well plate with protein in two positions and adding 96-reservoir of screen buffer from Hampton Research. 3 min long

Year:

2014

Link:

https://www.youtube.com/watch?v=ZwQ7P4MGHmU

Source:

youtube

Keywords:

Crystal Gryphon Protein Crystal Setup

Duration: 00:02;29

Photographing Protein Crystals

This tutorial shows how to examine and photograph protein crystals grown using hanging drop vapor diffusion method. In this demonstration we will use Motic Images and Motic Tek Firewire Camera and Leica S8 APO stereo zoom camera to examine and photograph the crystal images.

Year:

2013

Link:

https://www.youtube.com/watch?v=BQaIeh-QtqM

Source:

youtube

Keywords:

photos firewire camera protien crystals crystallization

Duration: 00:02:22

Flash Cooling a Protein Crystal in Cryo Stream

Flash Cooling a protein Crystal in Cryo Stream. Flash cooling of a protein crystal in gaseous nitrogen stream. First the cryo stream at 100 Kelvin is blocked using stream-blocker, usually a thin metal shim sheet. Then the crystal is picked up using a CryoLoop on a CrystalCap Magnetic from a crystal-growing buffer and brought to the goniometer. The stream is blocked and so crystal is at ambient temperature. Now, quickly we remove the blocker and let the 100 K gas hit the sample and sample is flash cooled to 100 K is less than a 1/10 of second.

Year:

2012

Link:

https://www.youtube.com/watch?v=Hn0vRRexbZY

Source:

youtube

Keywords:

Flash cooling cryo crystallography cryo stream protein crystals

Duration: 00:01:25

Flash Cooling Protein Crystal in bulk liquid nitrogen

This video shows the flash cooling of a protein crystal in bulk liquid nitrogen and transfering the crystal in a cryoloop into a cryo vial. Here the crystal is picked up using a CryoLoop on a CrystalCap Magnetic from a crystal-growing buffer and equilibrated in series of three cryo buffers.The crystal is then quickly flash cooled in bulk liquid nitrogen and slowly transferred into a pre-cooled cryovial. The crystal wand is removed after confirming the crystal transfer. The cryo vial with crystal is then transferred to a x-ray machine for data collection

Year:

2012

Link:

https://www.youtube.com/watch?v=yyY01zW_oaI

Source:

youtube

Keywords:

Flash cooling rapid cooling cryo crystallography

Duration: 00:03:28

Hanging Drop Vapor Diffusion Crystallization

In this tutorial, I will demonstrate how to set-up a hanging drop vapor diffusion protein crystallization set-up. Hanging drop crystal set-up is a common procedure for growing protein (macromolecular) crystals. In this demonstration I will show all the components needed: VDX Pre-greased plate, siliconized cover slip, pipettes, tips, protein, precipitant and other materials. Then in the second section I will show how to set-up 3 micro liters of protein (here enzyme lysozyme) and mix it 3 micro liters of a precipitant (here 10% sodium chloride) on a siliconized cover slip and seal it over a precipitant solution.