Research Terms
Center for Inflammation and Mucosal Immunology
| Director |
Liang Zhou |
| Phone | 352-273-6452 |
| Website | https://cimi.medicine.ufl.edu |
| Mission | Induced pathogenic inflammation is the hallmark of numerous human diseases, including the inflammatory bowel diseases, eosinophilic esophagitis, colon cancer, chronic infectious diseases, systemic pulmonary fibrosis, type 1 diabetes, wound healing, and the arthritides. The mission of the CIM is to elucidate the cellular and molecular basis of the inflammatory diseases in order to develop unique diagnostics and therapeutics for these disorders. We believe that targeted preventive or therapeutic strategies will become most effective when inflammatory cascades in host cells are understood in depth, and when the critical molecules involved in undesired induced inflammation are identified. |
This optical coherence tomography (OCT) probe uses an electrothermal microelectromechanical systems (MEMS) mirror kept in liquid to increase the optical scan range and shock resistance of OCT probes. OCT is a medical imaging technique that captures real-time, cross-sectional images from within tissue, which is vital for detecting cancers early, since most originate from within internal organs. OCT eliminates the risk of ionizing radiation, a problem with available imaging techniques, and produces high resolution images revealing detail down to micrometers. Electrothermal MEMS mirrors are useful in endoscopic OCT image probes because of their small size, high fill factor and low driving voltage. These mirrors, however, only offer a 60-degree scanning angle. This poses a problem in the case of bronchial scans, for example, which require a 360-degree full circumferential optical scan. Available MEMS OCT probes require multiple insertions of the probe inside the trachea in order to capture a full circumferential optical scan, which causes significant pain or discomfort for patients. To address this, University of Florida researchers have developed a MEMS OCT imaging probe that scans a full internal circumference in one insertion. The MEMS mirror immersed in liquid produces a Snell's window effect that amplifies the optical scan range and increases the shock resistance of the probe.
An OCT probe with a broad scanning angle that can capture a full-circumferential image of a tubular organ such as the bronchi with only one insertion
Available MEMS mirrors cannot work properly in liquid. The mirrors developed by University of Florida researchers have a large gap under the mirror plate in the substrate, which allows liquid to fill in while reducing the squeeze-film damping. The gap also allows the mirror plate to rotate in the liquid without causing stiction. When these mirrors are kept in liquid, the refraction of the light through the liquid creates a Snell’s effect that significantly amplifies the optical scan angle. This effect is very similar to the effect of a fisheye lens, and allows an OCT probe to view a full-circumferential image of a bronchi or other tubular organ with only one insertion into the patient.
