Research Terms
Vaccines Pulmonary Medicine Infectious Diseases
Keywords
Covid-19 Cyclic Dinucleotides Human Sting Variants Lung Mucosal Tolerance Pneumococcal Vaccines For The Elderly
a. Jin, L., Waterman, M.P., Jonscher, K.R., Short, C.M., Reisdorph, N.A., Cambier, J.C. MPYS, a novel membrane tetraspanner, is associated with MHC Class II and mediates transduction of apoptotic signals. Mol Cell Biol 28(16):5014-26. (2008). PMCID: PMC2519703
b. Jin, L., Xu, L.G., Yang, V. I., Davidson, E., Schwartz, D. A., Wurfel, M.M., and Cambier, J.C. Identification and Characterization of a Loss-of-Function Human MPYS Variant. Genes Immun 12(4): 263-9. (2011). PMCID: PMC3107388
c. Patel, S., Blaauboer, S.M., Tucker, H.R., Mansouri, S., Ruiz-Moreno, J.S., Hamann, L., Schumann, R.R., Opitz, B., Jin, L. The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele. J Immunol. 198(2):776-787. (2017). PMCID: PMC5225030 [Highlighted in This Issue, top 10% of the publication]
d. Blaauboer, S.M, Gabrielle, V.D, Jin, L., MPYS/STING-mediated TNF-a, not Type I IFN, production is essential for the Mucosal Adjuvant Activity of Cyclic-di-GMP in vivo J Immunol 192(1):492-502, (2014). PMID:24307739.
e. Blaauboer, S.M, Mansouri, S, Tucker, H.R, Wang, H.L, Gabrielle, V.D, Jin, L., The Mucosal Adjuvant Cyclic di-GMP Enhances Antigen Uptake and Selectively Activates Pinocytosis-efficient Cells in vivo Elife (2015). 10.7554/eLife.06670. PMCID: PMC4428110
f. Mansouri, S, Patel, S, Katikaneni, D, Blaauboer, S.M, Wang, W, S, Schattgen, S, Fitzgerald, K and Jin, L. Immature lung TNFR2- cDC2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo. Mucosal Immunology, 12(1):277-289. (2019). PMCID: PMC6301145
Society of Mucosal Immunology, Member; 2018 - present
International Cytokine & Interferon Society, Member; 2013 - present
America Association of Immunologists, Member; 2012 - present
General audience talk about a) how lung maintains its tolerance in health; b) how lung inflammation is self-propelled during chronic lung diseases; c) potential new treatments to increase efficacy and reduce the cost for lung patients.
Subject Areas:
Keywords:
Audience:
Adults
Duration:
1 hour or less
Fee:
Expenses Only
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