Expert Profile

Thomas Andl

BURNETT SCHOOL OF BIOMEDICAL SCIENCES - RESEARCH | COLLEGE OF MEDICINE

Research Terms & Keywords

Research Terms

Life Sciences Biological Models Cell Biology Regulatory Biology Histology Tumor Biology Biomedicine Skin

Keywords

Epidermis Hair Follicle Immunochemistry Microrna Oral Mucosa Skin Cancer Stem Cells

Research Projects

Ends

Title

11-2025

Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute

11-2025

Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute

05-2025

Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape

05-2025

Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape

05-2017

The role of microRNA miR-31 in skin biology The role of microRNA miR-31 in skin biology

Publications

(1). Homann, N., Andl, T., Nees, M., Schuhmann, A., Herold-Mende, C. & Bosch, F. X. Significance of aberrant p53 protein in head-neck tumors and its effect on proliferation and differentiation. HNO 1993 May, 41(5):254-260.

(2). Nees, M., Homann, N., Discher, H., Andl, T., Enders, C., Herold-Mende, C., Schuhmann, A. & Bosch, F. X. Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors. Cancer Res 1993 Sep 15, 53(18):4189-4196.

(3). Erber, R., Klein, W., Andl, T., Enders, C., Born, A. I., Conradt, C., Bartek, J. & Bosch, F. X. Aberrant p21(CIP1/WAF1) protein accumulation in head-and-neck cancer. Int J Cancer 1997 Aug 22, 74(4):383-389.

(4). Andl, T., Kahn, T., Pfuhl, A., Nicola, T., Erber, R., Conradt, C., Klein, W., Helbig, M., Dietz, A., Weidauer, H. & Bosch, F.X. Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res 1998 Jan 1, 58(1):5-13.

(5). Herold-Mende, C., Andl, T., Laemmler, F., Reisser, C. & Mueller, M. M. Functional expression of vascular endothelial growth factor receptor Flt-1 on squamous cell carcinoma of the head and neck. HNO 1999 Aug 24, 47(8):706-711.

(6). Herold-Mende, C., Andl, T., Laemmler, F., Reisser, C. & Eichhorn, S. Expression and localization profile of tenascin in squamous cell carcinomas of the head and neck. HNO 1999 Aug 24, 47(8):723-729.

(7). Nesbit, M., Nesbit, H. K., Bennett, J., Andl, T., Hsu, M.-Y., Dejesus, E., McBrian, M., Gupta, A. R., Eck, S. L. & Herlyn, M. Basic Fibroblast growth factor induces a Transformed Phenotype in Normal Human Melanocytes. Oncogene 1999, 18(47): 6469-6476.

(8). Herold-Mende, C., Steiner, H.-H., Andl, T., Riede, D., Buttler, A., Reisser, C., Fusenig, N. E. & Mueller, M. M. Expression and Functional Significance of VEGF Receptors in Human Tumor Cells. Lab Invest 1999, 79(12):1573-1582.

(9). Hsu, M.-Y., Andl, T., Meinkoth, J. L., Li, G. & Herlyn, M. Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J. Cell Science 2000, 113(9):1535-1542.

(10). Reddy, S., Andl T., Bagasra, A., Lu M. M., Epstein, D. J., Morrisey, E. E. & Millar, S. E. Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mechanisms of Development 2001 Sep;107(1-2):69-82.

(11). Andl, T., Reddy S. T., Gaddapara, T. & Millar, S. E. WNT signals are required for the initiation of hair follicle development. Developmental Cell 2002 May;2(5):643-53.

(12). Millar, S. E., Koyama, E., Reddy, S. T., Andl, T., Gaddapara, T., Piddington, R., Gibson, C. W. Over-and ectopic expression of Wnt3 causes progressive loss of ameloblasts from postnatal incisor teeth. Connective Tissue Research 2003;44 Suppl 1:124-9.

(13). Andl, T., Ahn, K., Kairo, A., Chu, E. Y., Wine-Lee, L., Reddy, S. T., Croft, N. C., Cebra-Thomas, J. A., Metzger, D., Chambon, P., Lyons, K. M., Mishina, Y., Seykora, J. T., Crenshaw, E. B., & Millar, S. E. Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development 2004 May;131(10):2257-68.

(14). Reddy, S. T.^ª, Andl, T.^ª,, Lu, M-M, Morrisey, E. E. & Millar, S. E. Expression of Frizzled genes in developing and postnatal hair follicles. Journal of Investigative Dermatology 2004 Aug;123(2):275-82. ^ªJoint first authors

(15). Chu, E. Y., Hens, J., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A., Wysolmerski, J. J., & Millar, S. E. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 2004 Oct;131(19):4819-29.

(16). Shu W, Guttentag S, Wang Z, Andl T, Ballard P, Lu MM, Piccolo S, Birchmeier W, Whitsett JA, Millar SE, Morrisey EE. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Developmental Biology 2005 Jul 1;283(1):226-39.

(17). Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development. 2004 Oct;131(19):4819-29.

(18). Andl T, Murchinson EP, Fei L, Zhang Y, Yunta-Gonzales M, Tobias JW, Andl CD, Seykora JT, Hannon GJ,& Millar SE. The miRNA-processing enzyme Dicer is essential for the morphogenesis and maintenance of hair follicles. Current Biology. 2006 May 23: 16:1-9.

(19). de Guzman Strong C, Wertz P, Pai S-Y, Ho I, Andl T, Millar SE, Segre JA. Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol. 2006 Nov 20 175(4):661-670.

(20). Liu F, Thirumangalathu S, Gallant NM, Yang SH, Stoick-Cooper CL, Reddy ST, Andl T, Taketo MM, Dlugosz AA, Moon RT, Barlow LA, Millar SE. Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 2007 Jan;39(1):106-12.

(21). Ito M, Yang Z, Andl T, Cui C, Kim N, Millar S, Cotsarelis G. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature. 2007 May 17, 447: 316-320.

(22). Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Millar SE. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008 Jan 1;313(1):210-24.

(23). Benetti R, Gonzalo S, Jaco I, Muñoz P, Gonzalez S, Schoeftner S, Murchison E, Andl T, Chen T, Klatt P, Li E, Serrano M, Millar S, Hannon G, Blasco MA. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol. 2008 Mar;15(3):268-79.

(24). Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE. Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008 Jun;135(12):2161-72.

(25). Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet. 2008 Sep;40(9):1130-5

(26). Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009 Jul;17(1):49-61.

(27). Osada M, Jardine L, Misir R, Andl T, Millar SE, Pezzano M. DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS One. 2010 Feb 8;5(2):e9062.

(28). Liu F, Dangaria S, Andl T, Zhang Y, Wright AC, Damek-Poprawa M, Piccolo S, Nagy A, Taketo MM, Diekwisch TG, Akintoye SO, Millar SE. beta-Catenin initiates tooth neogenesis in adult rodent incisors. J Dent Res. 2010 Sep;89(9):909-14.

(29). Plikus MV, Baker RE, Chen CC, Fare C, de la Cruz D, Andl T, Maini PK, Millar SE, Widelitz R, Chuong CM. Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science. 2011 Apr 29;332(6029):586-9.

(30). Teta M, Choi YS, Okegbe T, Wong G, Tam OH, Chong MMW, Seykora JT, Nagy A, Littman DR, Andl T, Sarah Millar. Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development 2012 Apr;139(8):1405-16.

(31). Choi YS, Zhang Y, Ito M, Cotsarelis G, Andl T, Millar, SE. Distinct functions for beta-catenin in hair follicle stem cell proliferation and survival. Cell Stem Cell 2013 Dec 5;13(6):720-33.

(32). Ning MS, Kim A, Prasad N, Levy SE, Zhang H, Andl T. Characterization of the Merkel cell carcinoma miRNome. J Skin Cancer 2014;2014:289548.

(33) Andl T, Le Bras GF, Richards NF, Allison GL, Loomans HA, Washington MK, Revetta F, Lee RK, Taylor C, Moses HL, Andl CD. Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. Carcinogenesis 2014 Sep 18. pii: bgu194

(34) Koumangoye RB, Andl T, Taubenslag KJ, Zilberman ST, Taylor CJ, Loomans HA, Andl CD. SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells. Mol Cancer 2015 Feb 3;14:24.

(35) Taylor C, Loomans HA, Le Bras GF, Koumangoye RB, Romero-Morales AI, Quast LL, Zaika AI, El-Rifai W, Andl T, Andl CD. Activin a signaling regulates cell invasion and proliferation in esophageal adenocarcinoma. Oncotarget 2015 Oct 6. doi: 10.18632/oncotarget.5349.

(36) Edmonds M, Boyd KL, Moyo T, Mitra R, Duszynski R, Arrate M, Chen X, Zhao Z, Blackwell T, Andl T, Eischen C. miR-31 initiates lung tumorigenesis and promotes mutant KRas-driven lung cancer. J Clin Invest. 2016 Jan;126(1):349-64.

(37) Zhou L, Yang K, Wickett RR, Andl T, Zhang Y. Dermal sheath cells contribute to postnatal hair follicle growth and cycling. J Dermatol Sci. 2016 May;82(2):129-31.

(38) Zhou L, Xu M, Yang Y, Yang K, Wickett RR, Andl T, Millar SE, Zhang Y. Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth. PLoS One. 2016 Jul 29;11(7):e0160425.

(39) Zhou L, Yang K, Carpenter A, Lang R, Andl T, Zhang Y. CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth. Biochem J. 2016 Jul 26. pii: BCJ20160466.

(40) Zhou L, Yang K, Xu M, Andl T, Millar SE, Boyce S, Zhang Y. Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity. FEBS J. 2016 Jun 17. doi: 10.1111/febs.13784.

(41) Andl CD, Le Bras GF, Loomans H, Kim AS, Zhou L, Zhang Y, Andl T. Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. Histochem Cell Biol. 2016 Aug 2.

(42) Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, His TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2017 Jan 5. pii: aai8792. doi: 10.1126/science.aai8792

Reviews, Case Reports, Letters, Editorials

(1). Andl T. miRNAs: miracle or mirage? The limes against the barbaric floods of leaky and undesired transcripts. Organogenesis 2007 3(1).

(2). Stark J, Andl T, Millar SE. Hairy math: insights into hair-follicle spacing and orientation. Cell Jan 2007 128(1): 17-20.

(3). Myung P, Andl T, Ito M. Defining the hair follicle stem cell (Part I). J Cutan Pathol. 2009 Sep;36(9):1031-4.

(4). Myung P, Andl T, Ito M. Defining the hair follicle stem cell (Part II). J Cutan Pathol. 2009 Oct;36(10):1134-7.

(5) Ning M, Andl T. Control by a hair's breadth: the role of microRNAs in the skin. Cell Mol Life Sci. 2013 Apr;70(7):1149-69.

(6) Ning M, Andl T. Custodians of the transcriptome: how microRNAs guard stemness in squamous epithelial stem cells. Stem Cells 2015 33(4):1047-54.

(7) Zhou L, Yank K, Andl T, Wickett RR, Zhang Y. Perspective of targeting cancer-associated fibroblasts in melanoma. J Cancer Jun23; 6(8):717-26.

(8) Andl T, Botchkareva NV. MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research. Exp Dermatol. 2015 Jun 29. doi: 10.1111/exd.12785.