Monoclonal antibodies targeting enzyme involved in silencing mRNA, proteins associated with liver cancer, tumor growth and post-transcription gene silencing

Monoclonal Antibody against p62/IGF2BP2

p62/IGF2BP2 is a cytoplasmic mRNA binding protein which binds to mRNA encoding IGF-II and may be involved in hepatic carcinogenesis because autoantibodies are found in a large percentage of patients with hepatocellular carcinoma. MAb were generated using the full length recombinant human protein as antigen.

Monoclonal Antibody against p90/CIP2A (gene name KIAA1524)

p90/CIP2A appears to have been conserved across species, but has no significant homology to any known gene products. It appears to be a companion auto-antigen to IGF2BP2 and represents a new marker for tumors such as hepatocellular carcinoma, gastric cancer and prostate cancer because autoantibodies are found in a large percentage of patients with these cancers. Overexpression of CIP2A has been demonstrated in human head and neck cancer. Antibodies were generated using the C-terminal third of the recombinant human protein as antigen. Journal article: http://www.nature.com/onc/journal/v21/n32/full/1205625a.html

Monoclonal Antibody against GW3 (gene name TNRC6C)

GW3 is a cellular protein closely related to GW182 protein. GW182 is a critical component of GW bodies, which are small cytoplasmic foci found in proliferating cells and are involved in post-transcriptional regulation of gene expression. Antibodies were generated using the full length recombinant human GW3 protein as antigen.