Research Terms
p62/IGF2BP2 is a cytoplasmic mRNA binding protein which binds to mRNA encoding IGF-II and may be involved in hepatic carcinogenesis because autoantibodies are found in a large percentage of patients with hepatocellular carcinoma. MAb were generated using the full length recombinant human protein as antigen.
p90/CIP2A appears to have been conserved across species, but has no significant homology to any known gene products. It appears to be a companion auto-antigen to IGF2BP2 and represents a new marker for tumors such as hepatocellular carcinoma, gastric cancer and prostate cancer because autoantibodies are found in a large percentage of patients with these cancers. Overexpression of CIP2A has been demonstrated in human head and neck cancer. Antibodies were generated using the C-terminal third of the recombinant human protein as antigen. Journal article: http://www.nature.com/onc/journal/v21/n32/full/1205625a.html
GW3 is a cellular protein closely related to GW182 protein. GW182 is a critical component of GW bodies, which are small cytoplasmic foci found in proliferating cells and are involved in post-transcriptional regulation of gene expression. Antibodies were generated using the full length recombinant human GW3 protein as antigen.
RNA interference (RNAi), triggered by small interfering RNA and microRNA (miRNA), is a potent mechanism in post-transcriptional regulation for gene expression. GW182 is a 182kDa protein which binds to the 3’ untranslated region of mRNA targeted by miRNA and resulting in translation suppression. Trinucleotide GW1 (TNGW1) is a novel 210kDa isoform of human GW182; so named because it contains trinucleotide repeats in the mRNA sequence. TNGW1 expresses independently of GW182 and is present in human testes and various human cancer cells. Journal article: http://jcs.biologists.org/content/121/24/4134.long
