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Samuel Grant

Professor and Director Of The NhmFL Mri User Program

NATIONAL HIGH MAGNETIC FIELD LABORATORY | FAMU-FSU COLLEGE OF ENGINEERING

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Research Terms & Keywords

Research Terms

Bioengineering Chemical Engineering Electromagnetic Materials Bioelectromagnetics Neuroanatomy Neurosciences Neuropathology Neurophysiology Neuronal Activity Neurology Radiology Magnetic Technology Imaging Technology Medical or Diagnostic Imaging Nuclear Magnetic Resonance

Keywords

Famu-Fsu College Of Engineering

Industries

Advanced Materials & Products Medical Devices

Research Projects

Ends

Title

03-2027

Targeting the orexin pathway to treat sleep disorders and improve glymphatic clearance in Alzheimer’s disease Targeting the orexin pathway to treat sleep disorders and improve glymphatic clearance in Alzheimer’s disease

Florida Department of Health

07-2025

Probing in Situ Higher Order Structures of Monoclonal Antibodies at Water-Air and Water-Oil Interfaces Via High-Field Nuclear Magnetic Resonance Spectroscopy for Viral Infections Probing in Situ Higher Order Structures of Monoclonal Antibodies at Water-Air and Water-Oil Interfaces Via High-Field Nuclear Magnetic Resonance Spectroscopy for Viral Infections

National Institute of Allergy

06-2025

Dysfunction Of Sodium Homeostasis In Migraine Dysfunction Of Sodium Homeostasis In Migraine

Huntington Medical Research Institutes

02-2025

Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy

National Institute of Neurolog

12-2023

Fluctuating sodium in the nervous system as the root cause of fluctuating brain function Fluctuating sodium in the nervous system as the root cause of fluctuating brain function

Huntington Medical Research Institutes

04-2023

MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke Therapy MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke Therapy

National Institute of Neurolog

04-2023

MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke Therapy MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke Therapy

National Institutes of Health

07-2022

Investigation Into hMSC-Derived Therapy in Ischemic Stroke at High Field MR Imaging and Spectroscopy Investigation Into hMSC-Derived Therapy in Ischemic Stroke at High Field MR Imaging and Spectroscopy

National Institutes of Health

05-2021

EIEG:Biochemical Analyzer for Cell Culture Facilities EIEG:Biochemical Analyzer for Cell Culture Facilities

FSU EIEG Award

01-2021

EIEG:Enhancing Biomedical Research at FSU Through a Small Animal Imaging System EIEG:Enhancing Biomedical Research at FSU Through a Small Animal Imaging System

FSU EIEG Award

05-2019

Collaboration On Migraine Research Collaboration On Migraine Research

Huntington Medical Research Institutes

11-2016

Translation of Human Mesenchymal Stem Cell Therapy for Stroke Treatment: Bioreactor Expansion, Functional Activation, and Intranasal Delivery Translation of Human Mesenchymal Stem Cell Therapy for Stroke Treatment: Bioreactor Expansion, Functional Activation, and Intranasal Delivery

Florida Department of Health

09-2016

MRI: Development of an NMR Console for the 36 T Series MRI: Development of an NMR Console for the 36 T Series

National Science Foundation

03-2016

Dysfunction Of Sodium Homeostasis In A Rat Migraine Model Dysfunction Of Sodium Homeostasis In A Rat Migraine Model

Huntington Medical Research Institutes

06-2013

Transplantation Of Culture Expanded Hmsc In Stroke Treatment Transplantation Of Culture Expanded Hmsc In Stroke Treatment

American Heart Association

12-2011

Collaborative Research: Are Muscle Fibers Just the Right Size? Collaborative Research: Are Muscle Fibers Just the Right Size?

National Science Foundation

Degrees

Ph.D., Bioengineering

University of Illinois, Chicago ▪ 2001
M.S., Electrical & Computer Engineering

University of Illinois, Urbana-Champaign ▪ 1998
B.S., Electrical & Computer Engineering

University of Illinois, Urbana-Champaign ▪ 1995

Awards & Honors

Senior Member

Institute of Electrical and Electronics Engineers ▪ 2010

Publications

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1. Webb AG, Grant SC. 1996. Signal-to-noise and magnetic susceptibility trade-offs in solenoidal microcoils for NMR. J. Magn. Reson. Ser. B. 113: 83-7. PMID: 8888593

2. Grant SC, Plant HD, Gibbs S, Aiken NR, Webb AG, Mareci TH, Blackband SJ. 2000. NMR Spectroscopy of Single Neurons. Magn. Reson. Med. 44: 19-22. PMID: 10893516

3. Grant SC, Murphy LA, Magin RL, Friedman G. 2001. Analysis of Multilayer RF Microcoils for NMR Spectroscopy. IEEE Trans. Magn. 34: 1-10.

4. Grant SC, Buckley DL, Gibbs S, Webb AG, Blackband SJ. 2001. MR Microscopy of Multiple Component Water Diffusion in Isolated Single Neurons. Magn. Reson. Med. 46: 1007-12. PMID: 11746576

5. Beck B, Plant HD, Grant SC, Thelwall PE, Silver X, Mareci TH, Benveniste H, Smith M, Collins C, Crozier S, Blackband SJ. 2002. Progress in High Field MRI at the University of Florida. MAGMA, 13: 152-7. PMID: 11755090

6. Thelwall PE, Grant SC, Blackband SJ. 2002. Human Erythrocyte Ghosts: Exploring the origins of multiexponential water diffusion in a model biological tissue with magnetic resonance. Magn. Reson. Med. 48: 649-57. PMID: 12353282

7. Simpson NE, Grant SC, Blackband SJ, Constantinidis I. 2003. NMR Properties of Alginate Microbeads. Biomaterials. 24: 4941-4948. PMID: 14559007

8. Wilson JMB, Petrik MS, Grant SC, Blackband SJ, Lai J, Shaw CA. 2004. Quantitative Measurement of Neurodegeneration in an ALS-PDC Model Using MR Microscopy. NeuroImage. 33: 336-343. PMID: 15325381

9. Grant SC, Celper S, Gauffin-Holmberg I, Simpson NE, Blackband SJ and Constantinidis I. 2005. Alginate Assessment by NMR Microscopy. J. Mater. Sci.: Mater. Med. 16: 511-14. PMID: 15928865

10. Sadleir RJ, Grant SC, DeMarse TB, Woo EJ, Lee SY, Kim TS, Oh SH, Lee BI, Seo JK. 2005. MRI/MEA compatibility at 17.6 Tesla. Int. Journ. Bioelectromagnetism. 7(1): 278-281.

11. Sadleir RJ, Grant SC, Silver X, Zhang SU, Woo EJ, Lee SY, Kim TS, Oh SH, Lee B, Seo JK. 2005. MREIT at 11T Field Strength. Int. Journ. Bioelectromagnetism. 7(1): 340-343.

12. Sadleir R, Grant SC, Zhang SU, Lee BI, Pyo HC, Oh SH, Park C, Woo EJ, Lee SY, Kwon O, Seo JK. 2005. Noise analysis in magnetic resonance electrical impedance tomography at 3 and 11 T field strengths. Physiol. Meas. 26: 875–84. PMID: 16088075

13. Fu R, Brey WW, Shetty K, Gor'kov P, Saha S, Long JR, Grant SC, Chekmenev EY, Hu J, Gan Z, Sharma M, Zhang F, Logan TM, Bruschweiler R, Edison A, Blue A, Dixon IR, Markiewicz WD, Cross TA. 2005. Ultra-wide bore 900MHz high-resolution NMR at the National High Magnetic Field Laboratory. J Magn Reson. 177(1): 1-8. PMID: 16125429

14. Ma Y, Hof PR, Grant SC, Blackband SJ, Bennett R, Slatest L, McGuigan MD, Benveniste H. 2005. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience. 134(4): 1203-15. PMID: 16165303

15. Marques JP, Grant SC, Blackband SJ and Bowtell RW. 2005. Intermolecular Multiple Quantum Coherences at High Magnetic Field: the Non-Linear Regime. J. Chem. Phys. 123(12): 164311. PMID: 16268701

16. Sadleir R, Zhang S, Grant S, Oh S, Lee B, Pyo H, Park C, Woo E, Lee S, Seo J, Kwon O. 2005. Noise Analysis of MREIT at 3T and 11T Field Strength. Conf Proc IEEE Eng Med Biol Soc. 3:2637-40. PMID: 17282780

17. Simpson NE, Grant SC, Gustavssond L, Peltonen VM, Blackband SJ and Constantinidis I. 2006. Biochemical consequences of alginate encapsulation: A NMR study of insulin-secreting cells. Biomaterials. 27(12): 2577-2586. PMID: 16364429

18. Sadleir R, Grant SC, Zhang SU, Oh SH, Lee BI and Woo EJ. 2006. High Field MREIT: Setup and tissue phantom imaging at 11 T. Physiol. Meas. 27(5): S261-S270. PMID: 16636417

19. Constantinidis I, Grant SC, Celper S, Gauffin-Holmberg I, Agering K, Oca-Cossio JA, Bui JD, Flint J, Hamaty C, Simpson NE and Blackband SJ. 2007. Non-invasive evaluation of alginate/poly-L-lysine/alginate microcapsules by Magnetic Resonance Microscopy. Biomaterials. 28(15): 2438-45. PMID: 17239948

20. Benveniste H, Ma Y, Dhawan J, Gifford A, Smith SD, Feinstein I, Du C, Grant SC, Hof PR. 2007. Anatomical and functional phenotyping of mice models of Alzheimer's disease by MR microscopy. Ann N Y Acad Sci. 1097: 12-29. PMID: 17413006

21. Petrik MS, Wilson JMB, Grant SC, Blackband SJ, Tabata RC, Shan X, Krieger C and Shaw CA. 2007. Magnetic resonance microscopy and immunohistochemistry of the central nervous system of the mutant SOD murine model of ALS. Neuromolecular Med. 9(3): 216-29. PMID: 17914180

22. Constantinidis I, Grant SC, Simpson NE, Oca-Cossio J, Sweeney CE, Mao H, Blackband SJ, Sambanis A. 2009. Use of Magnetic Nanoparticles to Monitor Alginate Encapsulated bTC-tet Cells. Magn Reson Med. 61(2): 282-90. PMID: 19165877

23. Schepkin VD, William W. Brey WW, Gor’kov PL, Grant SC. 2010. In vivo Rodent Sodium and Proton MR Imaging at 21 T. Magn. Reson. Imaging. 28(3): 400-7. PMID: 20045599

24. Schweitzer KJ, Foroutan P, Dickson DW, Broderick DF, Klose U, Berg D, Wszolek ZK, Grant SC. 2010. A novel approach to dementia: High Resolution 1H MRI of the Human Hippocampus Performed at 21.1 T. Neurology. 74(20): 1654. PMID: 20479366

25. Sadleir RJ, Grant SC, Woo EJ. 2010. Can high-field MREIT be used to directly detect neural activity? theoretical considerations. NeuroImage. 74(20): 1654. PMID: 20382240

26. Rosenberg JT, Kogot JM, Lovingood DD, Strouse GF, Grant SC. 2010. Intracellular Bimodal Nanoparticles Based on Quantum Dots for High-Field MRI at 21.1 T. Magn Reson Med. 64(3):871-82. PMID: 20575090

27. Masad IS, Grant SC. 2011. A Switchable Surface Coil for High Field 31P and 1H Acquisitions of the Mouse Leg. Physiol. Meas. 32(8): 1061-1081. PMID: 21677364

28. Fujioka S, Murray ME, Foroutan P, Schweitzer KJ, Dickson DW, Grant SC, Wszolek ZK. 2011. Magnetic resonance imaging with 21.1T and pathological correlations – diffuse Lewy body disease. Rinsho Shinkeigaku. 51(8): 603-607. PMID: 2187872.

29. Crowe JJ, Grant SC, Logan TM, Ma, T. 2011. A magnetic resonance-compatible perfusion bioreactor system for three-dimensional human mesenchymal stem cell construct development. Chemical Engineering Science. 66(18): 4138-4147. DOI: 10.1016/j.ces.2011.05.046

30. Rosenberg JT, Sachi-Kocher A, Davidson M, Grant SC. 2012. Intracellular SPIO Labeling of Microglia: High Field Considerations and Limitations for MR Microscopy. Contrast Media Mol Imaging. 7(2): 121-129. PMID: 22434624

31. Na HB, Palui G, Rosenberg JT, Ji X, Grant SC, Mattoussi H. 2012. Multidentate Catechol-Based Polyethylene Glycol Oligomers Provide Enhanced Stability and Biocompatibility to Iron Oxide Nanoparticles. ACS Nano. 6(1): 389-99. PMID: 22176202.

32. Wilson JM, Grant SC, Masad IS, Lee SR, Park YM, Stout JR, Loenneke JP, Arjmandi BH, Henning PC, Panton, LB, Kim JS. 2012. “Beta-Hydroxy-Beta-Methyl-Butyrate Blunts Negative Related Changes in Body Composition, Functionality, and Myofiber Dimensions in Rats.” J Intern Soc Sports Nutrition. 9(1): 18. PMID: 22512917

33. Qian C, Masad IS, Rosenberg JT, Elumalai M, Brey WW, Grant SC, Gor'kov PL. 2012. A volume birdcage coil with an adjustable sliding tuner ring for neuroimaging in high field vertical magnets: ex and in vivo applications at 21.1T. J Magn Reson. 221: 110-116. PMID: 22750638

34. Kim JS, Park YM, Lee SR, Masad IS, Khamoui AV, Jo E, Park BS, Arjmandi BH, Panton LB, Lee WJ, Grant SC. 2012. β-hydroxy-β-methylbutyrate did not enhance high intensity resistance training-induced improvements in myofiber dimensions and myogenic capacity in aged female rats. Mol Cells. 34(5): 439-448. PMID: 23149873

35. Foroutan P, Murray ME, Fujioka S, Schweitzer KJ, Dickson DW, Wszolek ZK, Grant SC. 2012. Progressive Supranuclear Palsy: High-Field-Strength MR Microscopy in the Human Substantia Nigra and Globus Pallidus. Radiology. In press [Epub ahead of print]. PMID: 23151826

Book Chapters

1. Constantinidis, I., Simpson, N. E., Grant, S. C., Blackband, S. J., Long Jr, R. C., & Sambanis, A. “Chapter 18: Non-invasive Monitoring of Tissue-Engineered Pancreatic Constructs by NMR Techniques.” Advances in Experimental Medicine and Biology: Tissue Engineering, J. P. Fisher (Ed.), Springer. ISBN-13: 978-0387-32664. PMID: 17120790

2. Walter GA, Santra S, Thattaliyath B and Grant SC. “Use of (Para)magnetic nanoparticles for labeling and tracking of stem cells and progenitors.” Nanoparticles in Biomedical Imaging: Emerging Technologies and Applications, JWM Bulte & MMJ Modo (Eds.), Springer (2008). ISBN-13: 978-0387720265.

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Memberships

IEEE Tallahassee Area Section, Chairperson; 2009 - present

Biomedical Engineering Society, Member; 2007 - present

Internationl Society for Magnetic Resonance in Medicine, Member; 1998 - present

Institute of Electrical and Electronics Engineers, Member; 1993 - present

Peer Review Positions

Extramural Program, University of Minnesota Center for Magnetic Resonance Research; 2012 - 2012

Major Programme Funding, Agence Nationale De La Recherche; 2011 - 2011

Separations, National Science Foundation; 2008 - 2008

Other Professional Activities

Chair, Professional Organization of the Institute for Electrical and Electronics Engineers, IEEE Tallahassee Area Section (2012). Primary Section Delegate for Tallahassee Area, IEEE 2011 Sections Congress, Institute for Electrical and Electronics Engineers (2011–present). San Francisco, CA. August 2011. Study Group Chair, Magnetic Resonance Engineering Study Group, International Society for Magnetic Resonance in Medicine (2010–2011). Vice Chair, Tallahassee Area Section, Institute for Electrical and Electronics Engineers (2010–2011). Study Group Chair-elect, Magnetic Resonance Engineering Study Group, International Society for Magnetic Resonance in Medicine (2009–2010). Covidien. Consultant (2007–2008). Journal for Electronic Defense. Guest Technical Editor (2007–2010).