Mosquito Repellent Device Invented to Protect Military Personnel
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Mosquito Repellent Device Invented to Protect Military Personnel
#NoBugNoBad
Research Terms
Neuroengineering Applied Science
Industries
“Murine embryonic stem cells in a rat decellularized kidney scaffold,” CD Batich, MJ Williams, T. Hamazaki, M. Ibanez, CA Adin, WL Clapp, GW Ellison, N. Terada, EA Ross, TERMIS North America 2007 Conference and Exposition, Toronto, Ontario, Canada, June 13, 2007 (Extended abstract).
“Persistent Skin Sanitizer (Nimbuderm™) with Sustained Microbicidal Properties,” David Moore, William Toreki, Roy Carr, Bernd Liesenfeld, Gregory Schultz, Christopher Batich, Albina Mikhaylova, Paul Dominguez, Jillian Vella, Gerald Olderman, SAWC & WHS 2008,
San Diego, CA, April 24-27, 2008. (POSTER - Blue Ribbon Award)
“Persistent Skin Sanitizer (Nimbuderm™) with Sustained Microbicidal Properties,” David Moore, William Toreki, Roy Carr, Bernd Liesenfeld, Gregory Schultz, Christopher Batich, Albina Mikhaylova, Paul Dominguez, Jillian Vella, Gerald Olderman, 2008 World Union of Wound Healing Societies, Toronto, Ontario, Canada, June 4-8, 2008. (POSTER - Blue Ribbon Award)
“High-resolution magnetic resonance imaging to quantify relaxation parameters in Alzheimer's brain tissue,” by Joanna F. Collingwood, Saurav Chandra, Mark Davidson, Albina Mikhaylova, Thomas Eskin, Jon Dobson, John Forder, and Christopher Batich, Alzheimer's & Dementia: The Journal of the Alzheimer's Association 4(4), T365-T366 (2008). (abstract)
“Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays,” SC McBain, U Griesenbach, S Xenariou, A Keramane, CD Batich, EWFW Alton and J Dobson, Nanotechnology, 19, 405102 (5pp) (2008).
“Biopolymers,” C Batich and P.Leamy, Chapter in “Standard Handbook of Biomedical Engineering and Design” 2nd ed. M. Kutz, McGraw-Hill (2009).
“Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds”.; Ross EA, Williams MJ, Hamazaki T, Terada N, Clapp WL, Adin C, Ellison GW, Jorgensen M, Batich CD.; J Am Soc Nephrol. 2009 Nov;20(11):2338-47. Epub 2009 Sep 3.
“Lessons from three successful (product on the market) translations,” Chris Batich, poster presented at the CTSA Industry Forum at NIH, February 17, 2010.
“Gelatinized Copper-Capillary Alginate Gel Functions as an Injectable Tissue Scaffolding System for Stem Cell Transplants,” Willenberg BJ, Zheng T, Meng FW, Meneses JC, Rossignol C, Batich CD, Terada N, Steindler DA, and Weiss MD. J Biomater Sci Polym Ed. 2010 Aug 9. [Epub ahead of print]
Pei-Yu Chung, Tzung-Hua Lin,, Gregory Schultz, Christopher Batich, and Peng Jiang; “Nanopyramid surface plasmon resonance sensors” Applied Physics Letters 96, 261108 (2010)
American Chemical Society, Member; 1985 - 2015
Early Detection of Injury Research, National Institutes of Health; 2006 - 2011
Bringing products to market: 3 examples; CTSI/Industry forum; National Institutes of Health (Bethesda, MD); 2010
This laparoscopic surgical instrument reduces the risk of tissue spillage and infection during the removal of solid or cystic pelvic masses from the abdomen, allowing surgeons to perform safe tissue removal through a minimally invasive incision. Laparoscopy has continued to revolutionize abdominal surgery for over 30 years, and surgeons perform 15 million laparoscopic surgical operations worldwide each year. Compared to open surgery, laparoscopic surgery is less painful, causes minimal scarring, and reduces recovery time. In one common application of laparoscopic surgery, surgeons remove potentially malignant pelvic masses from the abdomen using an endocatch surgical bag. If the bag ruptures during tissue removal, the tumorous contents may spill into the abdomen and cause serious harm to the patient through infection or the spread of cancer cells. Available laparoscopic systems do not adequately protect against tissue spillage during minimally invasive tissue removal.
Researchers at the University of Florida have developed a laparoscopic tissue removal system that increases the safety of minimally invasive surgical procedures. The surgical instrument successfully removes pelvic masses, eliminates the need for a large incision, and reduces the risk of potentially malignant tissue spilling into the patient.
Laparoscopic tool to remove pelvic masses through a minimally invasive incision, while protecting against harmful tissue spillage
This laparoscopic tissue removal system includes an adaptive sleeve, a containment reservoir, and a tissue manipulation device. The containment reservoir encloses the piece of tissue removed by the manipulation device during the procedure, and the tissue undergoes morcellation within the reservoir if necessary. The containment reservoir is attached to the adaptive sleeve, preventing spillage of the tissue. The system may also incorporate an indicator within the layers of the containment reservoir that allows the surgeon to visually assess its condition and provide an additional layer of protection for the patient undergoing the tissue removal surgery.
This antibacterial coating for the titanium screw that attaches the new implant to the bone of the jaw reduces the progression of peri-implant disease, which can lead to bone loss and eventual loss of the implant. Implants are a more common replacement for missing teeth than traditional fixed or removable dental prostheses. Approximately five percent of all dental implants anchored through osseointegration, or the attachment of human bone cells to a metal surface, will fail within ten years. Peri-implantitis, a degenerative, site-specific bacterial infection with no treatment options, causes inflammation of soft-tissue around the implant and bone loss following installation, making it the main cause of failed implants. Available implants traditionally use screws with a coating of titanium-nitride, which reduces corrosion and has good biocompatibility to help osseointegration. However, in those cases where peri-implantitis develops it can lead to loss of bone as well as failure of the implant. Attempts to coat the screw with charged metallic particles with antibacterial properties, such as copper, silver or magnesium, resulted in unfavorable interactions with surrounding tissue.
Researchers at the University of Florida have developed a titanium-nitride coating incorporating an antibacterial layer of quaternary nitrogen that has improved antiseptic properties without using charged metallic ions. Preliminary data indicates that the positively charged quaternized TiN outperforms traditional TiN coatings with a 40-50 percent reduction in bacteria.
Antibacterial dental implant coating that will reduce peri-implant disease and increase implant lifetime
The formation of the antimicrobial layer relies on producing a charged titanium-nitride (TiN) surface through a Menschutkin reaction, which is commonly used to synthesize quaternary ammonium salts. Creation of a charged TiN surface requires three steps. First, a titanium vapor solidifies, forming the titanium layer. Next, a titanium-nitride (TiN) layer forms through evaporation, chemical vapor deposition, plasma spray or sputtering, which coats the titanium layer. Finally, the titanium-nitride (TiN) quarternizes through a reaction of the titanium-nitride layer with an alkyl halide.
These point-of-care diagnostic tools employ high-sensitivity fluorescence to perform rapid and accurate assessment of protease presence and activity in a wound, thereby facilitating administration of optimal wound therapy. Protease imbalances are often responsible for the development of a range of medical pathologies, such as cancer cell metastasis or the spread of infectious diseases. High protease levels also can suppress pro-healing factors and destroy nascent tissue in chronic wounds, the treatment of which accounts for the largest share of the global wound care market, projected to exceed $22 billion by 2022. Available protease activity assays are generally for laboratory settings rather than point-of-care wound assessment by non-technical personnel, and many point-of-care diagnostic tools lack the analytical sensitivity needed to minimize testing time for more rapid and effective treatment of chronic wounds.
Researchers at the University of Florida have developed rapid, point-of-care protease detection assays that enable physicians to provide better treatment for chronic wounds. The devices are easy to use, completing their testing all within the same unit. They also exhibit very high analytical sensitivity that shortens overall testing time for more efficient chronic wound therapy.
Simple point-of-care diagnostic device to rapidly quantify protease levels or activity in wound tissue samples
These diagnostic tools utilize fluorescence resonance energy transfer (FRET) and colorimetric assay formats operating on a high-sensitivity substrate-cleaving mechanism to detect or quantify the activity of matrix metalloproteinase (MMP), a protease that indicates the chronic status of a wound when present in elevated amounts. A peptide substrate contains both a fluorescing dye molecule and a second molecule that quenches the fluorescence of the fluorescing dye. The substrate is specifically cleavable only by the MMPs. Therefore, if elevated protease levels exist in the sample, then quenching of the fluorescing dye ceases, and its fluorescence indicates the protease activity in the wound. This mechanism empowers multiple assay devices, including straw and swab-based testing tools as well as thin film substrates able to portray visually the spatial distribution of protease activity across the surface of a wound bed.
